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. 1978 Jul;35(1):69–76.

Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. I. Effect of single and double-stranded polynucleotides on Brucella abortus in vivo and in vitro.

E D Madraso, C Cheers
PMCID: PMC1457234  PMID: 680803

Abstract

The double stranded polynucleotide, poly A : U, when administered intraperitoneally at the same time as intravenous infection with Brucella abortus, suppressed the growth of that organism in the spleen and liver of mice. Single stranded poly A or poly U were not effective. On the other hand both the single and double stranded forms enhanced the growth of Br. abortus in broth culture. Poly A : U did not enhance the blood clearance of intravenously administered Br. abortus. Indeed its suppressive effect was not apparent until 2 days after administration. When mice given Br. abortus and poly A : U were given a second infection 2 days later, with either Br. abortus or Listeria monocytogens, the second infection was exacerbated, indicating a biphasic effect of poly A : U and antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cheers C., Cone R. E. Effect of polyadenine: polyuridine on brucellosis in conventional and congenitally athymic mice. J Immunol. 1974 Apr;112(4):1535–1539. [PubMed] [Google Scholar]
  2. Firshein W., Benson R. C., Sease M. Deoxycytidylate and deoxyguanylate kinase activity in pneumococci after exposure to known polyribonucleotides. Science. 1967 Aug 18;157(3790):821–822. doi: 10.1126/science.157.3790.821. [DOI] [PubMed] [Google Scholar]
  3. JENKIN C., PALMER D. L. Changes in the titre of serum opsonins and phagocytic properties of mouse peritoneal macrophages following injection of endotoxin. J Exp Med. 1960 Aug 1;112:419–429. doi: 10.1084/jem.112.2.419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. MACKANESS G. B. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med. 1964 Jul 1;120:105–120. doi: 10.1084/jem.120.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Schmidtke J. R., Johnson A. G. Regulation of the immune system by synthetic polynucleotides. I. Characteristics of adjuvant action on antibody synthesis. J Immunol. 1971 May;106(5):1191–1200. [PubMed] [Google Scholar]
  6. Sulitzeanu D. Mechanism of immunity against brucella. Nature. 1965 Mar 13;205(976):1086–1088. doi: 10.1038/2051086a0. [DOI] [PubMed] [Google Scholar]

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