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. 1979 Jan;36(1):145–149.

The effect of age on IgE production in rats.

R Pauwels, H Bazin, B Platteau, M van der Straeten
PMCID: PMC1457382  PMID: 422226

Abstract

Inbred BN-rats were immunized at different ages with a standardized amount of ovalbumin and a1(OH)3. The specific IgE antibody response and total serum IgE levels were significantly influenced by age. The IgE antibody response increased to a maximum in 2-month-old rats and decreased progressively at a more advanced age. Total serum IgE levels increased progressively from the age of 1 month to the age of 5 months and decreased again at the age of one year.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbee R. A., Lebowitz M. D., Thompson H. C., Burrows B. Immediate skin-test reactivity in a general population sample. Ann Intern Med. 1976 Feb;84(2):129–133. doi: 10.7326/0003-4819-84-2-129. [DOI] [PubMed] [Google Scholar]
  2. Binaghi R. A., Oettgen H. F., Benacerraf B. Anaphylactic antibody in the young rat. Int Arch Allergy Appl Immunol. 1966;29(2):105–111. doi: 10.1159/000229692. [DOI] [PubMed] [Google Scholar]
  3. Delespesse G., De Maubeuge J., Kennes B., Nicaise R., Govaerts A. IgE mediated hypersensitivity in ageing. Clin Allergy. 1977 Mar;7(2):155–160. doi: 10.1111/j.1365-2222.1977.tb01436.x. [DOI] [PubMed] [Google Scholar]
  4. Ishizaka K., Ishizaka T., Hornbrook M. M. Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J Immunol. 1966 Jul;97(1):75–85. [PubMed] [Google Scholar]
  5. Ishizaka K., Ishizaka T., Okudaira H., Bazin H. Ontogeny of IgE-bearing lymphocytes in the rat. J Immunol. 1978 Feb;120(2):655–660. [PubMed] [Google Scholar]
  6. Levine B. B., Vaz N. M. Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy. Int Arch Allergy Appl Immunol. 1970;39(2-3):156–171. doi: 10.1159/000230343. [DOI] [PubMed] [Google Scholar]
  7. Pauwels R., Bazin H., Platteau B., Van Der Straeten M. In vitro measurement of specific rat IgE antibodies. Ann Immunol (Paris) 1977 Apr-Jun;128C(3):675–685. [PubMed] [Google Scholar]
  8. Pauwels R., Bazin H., Platteau B., van der Straeten M. The measurement of total serum IgE levels in rats. J Immunol Methods. 1977;18(1-2):133–140. doi: 10.1016/0022-1759(77)90164-8. [DOI] [PubMed] [Google Scholar]
  9. Prouvost-Danon A., Binaghi R. Reaginic antibody in adult and young mice. Production and biological properties. Int Arch Allergy Appl Immunol. 1970;38(6):648–656. doi: 10.1159/000230320. [DOI] [PubMed] [Google Scholar]

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