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. 1978 Dec;35(6):1005–1008.

Elevated autorosette formation by lymphocytes of dogs affected with cyclic neutropenia (CN)

Kathleen Angus, T J Yang
PMCID: PMC1457441  PMID: 738763

Abstract

Cyclic neutropenia (CN) is an inherited disorder characterized by regularly recurring episodes of neutropenia in humans and Gray Collie dogs. Early thymic hypotrophy and lymphoid exhaustion in the CN dogs suggests there may be a lymphoid cell differentiation defect. Later manifestations of CN in dogs include arthritis, anaemia, glomerulone-phritis, and amyloidosis which are often associated with autoimmune diseases. Several Coombs' antiglobulin tests were performed and did not detect autoantibodies, however, peripheral blood lymphocytes from CN dogs formed rosettes with their own erythrocytes while in normal dogs such rosettes were extremely rare. Furthermore, when lymphocytes from CN dogs were rosetted with erythrocytes from normal dogs, the numbers of allogeneic rosettes were comparable to those formed with autologous erythrocytes. These results suggest strongly that the rosetting lymphocytes are specific for common erythrocyte surface components. Although the physiological importance of the autorosetting phenomenon is not known, the frequency of autorosette formation in CN dogs, as reported here, suggests that it may be an early indication of developing autoimmune activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baxley G., Bishop G. B., Cooper A. G., Wortis H. H. Rosetting of human red blood cells to thymocytes and thymus-derived cells. Clin Exp Immunol. 1973 Nov;15(3):385–392. [PMC free article] [PubMed] [Google Scholar]
  2. Charreire J., Bach J. F. Binding of autologous erythrocytes to immature T-cells. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3201–3205. doi: 10.1073/pnas.72.8.3201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cheville N. F., Cutlip R. C., Moon H. W. Microscopic pathology of the gray collie syndrome. Cyclic neutropenia, amyloidosis, enteritis, and bone necrosis. Pathol Vet. 1970;7(3):225–245. doi: 10.1177/030098587000700302. [DOI] [PubMed] [Google Scholar]
  4. Cheville N. F. The gray Collie syndrome. J Am Vet Med Assoc. 1968 Mar 15;152(6):620–630. [PubMed] [Google Scholar]
  5. Dale D. C., Alling D. W., Wolff S. M. Cyclic hematopoiesis: the mechanism of cyclic neutropenia in grey collie dogs. J Clin Invest. 1972 Aug;51(8):2197–2204. doi: 10.1172/JCI107027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Duffus W. P., Allan D. A study of the ontogeny of specific immune responsiveness amongst circulating leucocytes in the chicken. Immunology. 1969 Mar;16(3):337–347. [PMC free article] [PubMed] [Google Scholar]
  7. Goldstein A. L., Guha A., Howe M. L., White A. Ontogenesis of cell-mediated immunity in murine thymocytes and spleen cells and its acceleration by thymosin, a thymic hormone. J Immunol. 1971 Mar;106(3):773–780. [PubMed] [Google Scholar]
  8. Gregory R. S., Machado E. A., Jones J. B. Animal model of human disease. Amyloidosis. Am J Pathol. 1977 Jun;87(3):721–724. [PMC free article] [PubMed] [Google Scholar]
  9. Jones J. B., Yang T. J., Dale J. B., Lange R. D. Canine cyclic haematopoiesis: marrow transplantation between littermates. Br J Haematol. 1975 Jun;30(2):215–223. doi: 10.1111/j.1365-2141.1975.tb00535.x. [DOI] [PubMed] [Google Scholar]
  10. Kaplan J. Human T lymphocytes form rosettes with autologous and allogeneic human red blood cells. Clin Immunol Immunopathol. 1975 Mar;3(4):471–475. doi: 10.1016/0090-1229(75)90071-9. [DOI] [PubMed] [Google Scholar]
  11. Lund J. E., Padgett G. A., Ott R. L. Cyclic neutropenia in grey collie dogs. Blood. 1967 Apr;29(4):452–461. [PubMed] [Google Scholar]
  12. Lustig H. J., Nussenzweig V., Nussenzweig R. S. Erythrocyte membrane-associated immunoglobulins during malaria infection of mice. J Immunol. 1977 Jul;119(1):210–216. [PubMed] [Google Scholar]
  13. Micklem H. S., Asfi C., Staines N. A., Anderson N. Quantitative study of cells reacting to skin allografts. Nature. 1970 Aug 29;227(5261):947–949. doi: 10.1038/227947a0. [DOI] [PubMed] [Google Scholar]
  14. Miyazaki S. Immunological studies on cyclic neutropenia. Nihon Ketsueki Gakkai Zasshi. 1974 Jun;37(3):276–281. [PubMed] [Google Scholar]
  15. Reynolds H. Y., Dale D. C., Wolff S. M., Johnson J. S. Serum immunoglobulin levels in grey collies. Proc Soc Exp Biol Med. 1971 Feb;136(2):574–577. doi: 10.3181/00379727-136-35314. [DOI] [PubMed] [Google Scholar]
  16. Sandilands G. P., Gray K., Cooney A., Browning J. D. Formation of auto-rosettes by peripheral blood lymphocytes. Clin Exp Immunol. 1975 Dec;22(3):493–501. [PMC free article] [PubMed] [Google Scholar]
  17. Weiden P. L., Robinett B., Graham T. C., Adamson J., Storb R. Canine cyclic neutropenia. A stem cell defect. J Clin Invest. 1974 Mar;53(3):950–953. doi: 10.1172/JCI107636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yang T. J. Recovery of hair coat color in Gray Collie (cyclic neutropenia)-normal bone marrow transplant chimeras. Am J Pathol. 1978 Apr;91(1):149–153. [PMC free article] [PubMed] [Google Scholar]

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