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. 1980 Mar;39(3):331–336.

Antigen-specific mast cell degranulation in contact sensitivity to picryl chloride. An early event.

W R Thomas, N Vardinon, M C Watkins, G L Asherson
PMCID: PMC1457792  PMID: 6160091

Abstract

Mast cells from the peritoneum of mice painted with the contact sensitizing agent picryl chloride degranulate when exposed to antigen (TNP) in vitro. Degranulation was consistently demonstrated 4 days after painting which associated with the ability of mice to produce contact sensitivity reactions as measured by ear swelling and radiometric assays. Serum reagin or reagin-producing cells could not be detected until 6 days after painting but TNP-phage neutralizing activity was detected after 2 days. Mast cell degranulation could be elicited by TNP or DNP derivatives indicating the involvement of antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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