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. 1980 Aug;40(4):657–664.

J segment in human delta chains.

C P Milstein, E V Deverson
PMCID: PMC1458091  PMID: 6776038

Abstract

We report the complete sequence of a cyanogen bromide fragment of a human delta chain (ErI). Its interest lies in the fact that it contains the peptide joining the V delta to the C delta 1 region. The presented sequence is compared with the homologous region of other human heavy chain classes and subclasses. The possibility that human delta chains and other human heavy chains have in their chromosomal DNA a short J sequence, is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bourgois A., Fougereau M., De Preval C. Sequence of amino acids of the NH 2 -terminal region of a mouse-clonal immunoglobulin heavy chain. Eur J Biochem. 1972 Jan 21;24(3):446–455. doi: 10.1111/j.1432-1033.1972.tb19705.x. [DOI] [PubMed] [Google Scholar]
  2. Connell G. E., Parr D. M., Hofmann T. The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein. Can J Biochem. 1979 Jun;57(6):758–767. doi: 10.1139/o79-094. [DOI] [PubMed] [Google Scholar]
  3. Frangione B., Franklin E. C. Correlation between fragmented immunoglobulin genes and heavy chain deletion mutants. Nature. 1979 Oct 18;281(5732):600–602. doi: 10.1038/281600a0. [DOI] [PubMed] [Google Scholar]
  4. Fruchter R. G., Jackson S. A., Mole L. E., Porter R. R. Sequence studies of the Fd section of the heavy chain of rabbit immunoglobulin G. Biochem J. 1970 Jan;116(2):249–259. doi: 10.1042/bj1160249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gally J. A., Edelman G. M. The genetic control of immunoglobulin synthesis. Annu Rev Genet. 1972;6:1–46. doi: 10.1146/annurev.ge.06.120172.000245. [DOI] [PubMed] [Google Scholar]
  6. Kehry M., Sibley C., Fuhrman J., Schilling J., Hood L. E. Amino acid sequence of a mouse immunoglobulin mu chain. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2932–2936. doi: 10.1073/pnas.76.6.2932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kocher H. P., Spiegelberg H. L. Tryptic degradation of the CH1 and VL regions of IgD and IgE. J Immunol. 1979 Apr;122(4):1190–1195. [PubMed] [Google Scholar]
  8. Kratzin H., Altevogt P., Ruban E., Kortt A., Staroscik K., Hilschmann N. Die Primärstruktur eines monoklonalen IgA-Immunoglobulins (IgA Tro.), II. Die Aminosäuresequenz der H-Kette, alpha-Typ, Subgruppe III. Struktur des gesamten IgA-Moleküls. Hoppe Seylers Z Physiol Chem. 1975 Aug;356(8):1337–1342. [PubMed] [Google Scholar]
  9. Milstein C. P., Feinstein A. Comparative studies of two types of bovine immunoglobulin G heavy chains. Biochem J. 1968 Apr;107(4):559–564. doi: 10.1042/bj1070559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Milstein C. P., Northrop F. N-terminal amino acid sequence of a human delta-chain myeloma protein. Eur J Immunol. 1976 Mar;6(3):222–224. doi: 10.1002/eji.1830060315. [DOI] [PubMed] [Google Scholar]
  11. Milstein C. A simple procedure for the fractionation of the tryptic peptides of the C-terminal half of immunoglobulin lambda-chains. Biochem J. 1968 Dec;110(4):652–654. doi: 10.1042/bj1100652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Milstein C., Munro A. J. The genetic basis of antibody specificity. Annu Rev Microbiol. 1970;24:335–358. doi: 10.1146/annurev.mi.24.100170.002003. [DOI] [PubMed] [Google Scholar]
  13. Offord R. E. Electrophoretic mobilities of peptides on paper and their use in the determination of amide groups. Nature. 1966 Aug 6;211(5049):591–593. doi: 10.1038/211591a0. [DOI] [PubMed] [Google Scholar]
  14. Perry M. B., Milstein C. Interchain bridges of human IgD. Nature. 1970 Dec 5;228(5275):934–935. doi: 10.1038/228934a0. [DOI] [PubMed] [Google Scholar]
  15. Pink J. R., Buttery S. H., De Vries G. M., Milstein C. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. Biochem J. 1970 Mar;117(1):33–47. doi: 10.1042/bj1170033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Press E. M., Hogg N. M. The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains. Biochem J. 1970 May;117(4):641–660. doi: 10.1042/bj1170641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Putnam F. W., Florent G., Paul C., Shinoda T., Shimizu A. Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin. Science. 1973 Oct 19;182(4109):287–291. doi: 10.1126/science.182.4109.287. [DOI] [PubMed] [Google Scholar]
  18. Rao D. N., Rudikoff S., Krutzsch H., Potter M. Structural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2890–2894. doi: 10.1073/pnas.76.6.2890. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Robinson E. A., Appella E. Amino acid sequence of a mouse myeloma immunoglobin heavy chain (MOPC 47 A) with a 100-residue deletion. J Biol Chem. 1979 Nov 25;254(22):11418–11430. [PubMed] [Google Scholar]
  20. Rudikoff S., Potter M. Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein. Biochemistry. 1974 Sep 10;13(19):4033–4038. doi: 10.1021/bi00716a034. [DOI] [PubMed] [Google Scholar]
  21. Sakano H., Hüppi K., Heinrich G., Tonegawa S. Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature. 1979 Jul 26;280(5720):288–294. doi: 10.1038/280288a0. [DOI] [PubMed] [Google Scholar]
  22. Sakano H., Rogers J. H., Hüppi K., Brack C., Traunecker A., Maki R., Wall R., Tonegawa S. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments. Nature. 1979 Feb 22;277(5698):627–633. doi: 10.1038/277627a0. [DOI] [PubMed] [Google Scholar]
  23. Seidman J. G., Max E. E., Leder P. A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature. 1979 Aug 2;280(5721):370–375. doi: 10.1038/280370a0. [DOI] [PubMed] [Google Scholar]
  24. Spiegelberg H. L. NH2-terminal amino acid sequence of the Fc fragment of IgD resembles IgE and IgG sequences. Nature. 1975 Apr 24;254(5502):723–725. doi: 10.1038/254723a0. [DOI] [PubMed] [Google Scholar]
  25. Spiegelberg H. L. The structure and biology of human IgD. Immunol Rev. 1977;37:3–24. doi: 10.1111/j.1600-065x.1977.tb00243.x. [DOI] [PubMed] [Google Scholar]
  26. Tsuzukida Y., Wang C. C., Putnam F. W. Structure of the A2m(1) allotype of human IgA--a recombinant molecule. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1104–1108. doi: 10.1073/pnas.76.3.1104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Watanabe S., Barnikol H. U., Horn J., Bertram J., Hilschmann N. Die Primärstruktur eines monoklonalen IgM-Immunoglobulins (Makroglobulin Gal.), II. Die Aminosäuresequenz der H-Kette (mu-Typ,Subgruppe HIII), Struktur des gesamten IgM-Moleküls. Hoppe Seylers Z Physiol Chem. 1973 Oct-Nov;354(10-11):1505–1509. [PubMed] [Google Scholar]
  28. Woods K. R., Wang K. T. Separation of dansyl-amino acids by polyamide layer chromatography. Biochim Biophys Acta. 1967 Feb 21;133(2):369–370. doi: 10.1016/0005-2795(67)90078-5. [DOI] [PubMed] [Google Scholar]

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