Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1981 Jan;42(1):1–6.

Thymus-dependent lymphocytes of dengue virus-infected mice spleens mediate suppression through prostaglandin.

U C Chaturvedi, M I Shukla, A Mathur
PMCID: PMC1458198  PMID: 6450729

Abstract

Our earlier observations indicate that adoptive transfer of spleen cells obtained from dengue type 2 virus (DV)-primed mice suppressed DV antigen-specific antibody secretion as detected by Jerne PFC technique. Findings of this paper indicate that the suppression was produced by non-glass-adherent cells, macrophage-depleted (by carbonyl iron) cells and by T lymphocytes of the spleen but not by the glass-adherent cells and B lymphocytes. The activity of these cells is dependent upon production of prostaglandin as shown by abrogation of their suppressor activity by pre-treatment of cells by indomethacin or aspirin which are known to block synthesis of prostaglandins.

Full text

PDF
4

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agrawal D. K., Tandon P., Chaturvedi U. C., Kumar A. Biochemical study of certain enzymes and metabolites of the carbohydrate metabolism in the skeletal muscle of the dengue virus-infected mice. J Gen Virol. 1978 Aug;40(2):399–408. doi: 10.1099/0022-1317-40-2-399. [DOI] [PubMed] [Google Scholar]
  2. Basten A., Miller J. F., Johnson P. T cell-dependent suppression of an anti-hapten antibody response. Transplant Rev. 1975;26:130–169. doi: 10.1111/j.1600-065x.1975.tb00178.x. [DOI] [PubMed] [Google Scholar]
  3. Carpenter C. R., Bose H. R., Rubin A. S. Contact-mediated suppression of mitogen-induced responsiveness by spleen cells in reticuloendotheliosis virus-induced tumorigenesis. Cell Immunol. 1977 Oct;33(2):392–401. doi: 10.1016/0008-8749(77)90167-8. [DOI] [PubMed] [Google Scholar]
  4. Chaturvedi U. C., Dalakoti H., Mathur A. Characterization of the cytotoxic factor produced in the spleen of dengue virus-infected mice. Immunology. 1980 Oct;41(2):387–392. [PMC free article] [PubMed] [Google Scholar]
  5. Chaturvedi U. C., Mathur A., Tandon P., Natu S. M., Rajvanshi S., Tandon H. O. Variable effect on peripheral blood leucocytes during JE virus infection of man. Clin Exp Immunol. 1979 Dec;38(3):492–498. [PMC free article] [PubMed] [Google Scholar]
  6. Chaturvedi U. C., Tandon H. O., Mathur A. Control of in vitro and in vivo spread of coxsackievirus B4 infection by sensitized spleen cells and antibody. J Infect Dis. 1978 Aug;138(2):181–190. doi: 10.1093/infdis/138.2.181. [DOI] [PubMed] [Google Scholar]
  7. Chaturvedi U. C., Tandon P., Mathur A. Effect of immunosuppression on dengue virus infection in mice. J Gen Virol. 1977 Sep;36(3):449–458. doi: 10.1099/0022-1317-36-3-449. [DOI] [PubMed] [Google Scholar]
  8. Chaturvedi U. C., Tandon P., Mathur A., Kumar A. Host defence mechanisms against dengue virus infection of mice. J Gen Virol. 1978 May;39(2):293–302. doi: 10.1099/0022-1317-39-2-293. [DOI] [PubMed] [Google Scholar]
  9. Cross S. S., Morse H. C., Asofsky R. Neonatal infection with mouse thymic virus. Differential effects on T cells mediating the graft-versus-host reaction. J Immunol. 1976 Aug;117(2):635–638. [PubMed] [Google Scholar]
  10. Ferraris V. A., DeRubertis F. R. Release of prostaglandin by mitogen- and antigen-stimulated leukocytes in culture. J Clin Invest. 1974 Aug;54(2):378–386. doi: 10.1172/JCI107773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gershon R. K. T cell control of antibody production. Contemp Top Immunobiol. 1974;3:1–40. doi: 10.1007/978-1-4684-3045-5_1. [DOI] [PubMed] [Google Scholar]
  12. Goodwin J. S., Bankhurst A. D., Messner R. P. Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. J Exp Med. 1977 Dec 1;146(6):1719–1734. doi: 10.1084/jem.146.6.1719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jerne N. K., Nordin A. A. Plaque Formation in Agar by Single Antibody-Producing Cells. Science. 1963 Apr 26;140(3565):405–405. doi: 10.1126/science.140.3565.405. [DOI] [PubMed] [Google Scholar]
  14. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  15. Kapp J. A., Pierce C. W., Theze J., Benacerraf B. Modulation of immune responses by suppressor T cells. Fed Proc. 1978 Aug;37(10):2361–2364. [PubMed] [Google Scholar]
  16. Katz S. I., Parker D., Turk J. L. B-cell suppression of delayed hypersensitivity reactions. Nature. 1974 Oct 11;251(5475):550–551. doi: 10.1038/251550a0. [DOI] [PubMed] [Google Scholar]
  17. Kurland J. I., Bockman R. Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages. J Exp Med. 1978 Mar 1;147(3):952–957. doi: 10.1084/jem.147.3.952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mattingly J. A., Kemp J. D. Suppression of secondary plaque-forming cell responses by rat splenic adherent cells: evidence for dependence on prostaglandin production. Cell Immunol. 1979 Nov;48(1):195–200. doi: 10.1016/0008-8749(79)90111-4. [DOI] [PubMed] [Google Scholar]
  19. Neta R., Salvin S. B. Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity. J Immunol. 1974 Dec;113(6):1716–1725. [PubMed] [Google Scholar]
  20. Ptak W., Gershon R. K. Immunosuppression effected by macrophage surfaces. J Immunol. 1975 Nov;115(5):1346–1350. [PubMed] [Google Scholar]
  21. Rich R. R., Pierce C. W. Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes. J Exp Med. 1973 Mar 1;137(3):649–659. doi: 10.1084/jem.137.3.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tandon P., Chaturvedi U. C., Mathur A. Dengue virus-induced thymus-derived suppressor cells in the spleen of mice. Immunology. 1979 Dec;38(4):653–658. [PMC free article] [PubMed] [Google Scholar]
  23. Trizio D., Cudkowicz G. Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo. J Immunol. 1974 Oct;113(4):1093–1097. [PubMed] [Google Scholar]
  24. Waksman B. H. Cellular hypersensitivity and immunity: conceptual changes in last decade. Cell Immunol. 1979 Jan;42(1):155–169. doi: 10.1016/0008-8749(79)90229-6. [DOI] [PubMed] [Google Scholar]
  25. Webb D. R., Nowowiejski I. The role of prostaglandins in the control of the primary 19S immune response to sRBC. Cell Immunol. 1977 Sep;33(1):1–10. doi: 10.1016/0008-8749(77)90129-0. [DOI] [PubMed] [Google Scholar]
  26. Webb D. R., Osheroff P. L. Antigen stimulation of prostaglandin synthesis and control of immune responses. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1300–1304. doi: 10.1073/pnas.73.4.1300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Zimecki M., Webb D. R. The regulation of the immune response to T-independent antigens by prostaglandins and B cells. J Immunol. 1976 Dec;117(6):2158–2164. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES