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Genetics logoLink to Genetics
. 2000 Apr;154(4):1785–1791. doi: 10.1093/genetics/154.4.1785

The origin of the domestic pig: independent domestication and subsequent introgression.

E Giuffra 1, J M Kijas 1, V Amarger 1, O Carlborg 1, J T Jeon 1, L Andersson 1
PMCID: PMC1461048  PMID: 10747069

Abstract

The domestic pig originates from the Eurasian wild boar (Sus scrofa). We have sequenced mitochondrial DNA and nuclear genes from wild and domestic pigs from Asia and Europe. Clear evidence was obtained for domestication to have occurred independently from wild boar subspecies in Europe and Asia. The time since divergence of the ancestral forms was estimated at approximately 500,000 years, well before domestication approximately 9,000 years ago. Historical records indicate that Asian pigs were introduced into Europe during the 18th and early 19th centuries. We found molecular evidence for this introgression and the data indicated a hybrid origin of some major "European" pig breeds. The study is an advance in pig genetics and has important implications for the maintenance and utilization of genetic diversity in this livestock species.

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Selected References

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  1. Andersson L., Haley C. S., Ellegren H., Knott S. A., Johansson M., Andersson K., Andersson-Eklund L., Edfors-Lilja I., Fredholm M., Hansson I. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science. 1994 Mar 25;263(5154):1771–1774. doi: 10.1126/science.8134840. [DOI] [PubMed] [Google Scholar]
  2. Archibald A. L., Haley C. S., Brown J. F., Couperwhite S., McQueen H. A., Nicholson D., Coppieters W., Van de Weghe A., Stratil A., Winterø A. K. The PiGMaP consortium linkage map of the pig (Sus scrofa). Mamm Genome. 1995 Mar;6(3):157–175. doi: 10.1007/BF00293008. [DOI] [PubMed] [Google Scholar]
  3. Brown W. M., George M., Jr, Wilson A. C. Rapid evolution of animal mitochondrial DNA. Proc Natl Acad Sci U S A. 1979 Apr;76(4):1967–1971. doi: 10.1073/pnas.76.4.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Darvasi A., Soller M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics. 1995 Nov;141(3):1199–1207. doi: 10.1093/genetics/141.3.1199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Harbitz I., Chowdhary B. P., Kran S., Davies W. Characterization of a porcine glucosephosphate isomerase-processed pseudogene at chromosome 1q1.6-1.7. Mamm Genome. 1993;4(10):589–592. doi: 10.1007/BF00361390. [DOI] [PubMed] [Google Scholar]
  6. Harpending H. C., Batzer M. A., Gurven M., Jorde L. B., Rogers A. R., Sherry S. T. Genetic traces of ancient demography. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1961–1967. doi: 10.1073/pnas.95.4.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hiendleder S., Lewalski H., Wassmuth R., Janke A. The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotype. J Mol Evol. 1998 Oct;47(4):441–448. doi: 10.1007/pl00006401. [DOI] [PubMed] [Google Scholar]
  8. Irwin D. M., Kocher T. D., Wilson A. C. Evolution of the cytochrome b gene of mammals. J Mol Evol. 1991 Feb;32(2):128–144. doi: 10.1007/BF02515385. [DOI] [PubMed] [Google Scholar]
  9. Kijas J. M., Wales R., Törnsten A., Chardon P., Moller M., Andersson L. Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. Genetics. 1998 Nov;150(3):1177–1185. doi: 10.1093/genetics/150.3.1177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kimura M. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol. 1980 Dec;16(2):111–120. doi: 10.1007/BF01731581. [DOI] [PubMed] [Google Scholar]
  11. Loftus R. T., MacHugh D. E., Bradley D. G., Sharp P. M., Cunningham P. Evidence for two independent domestications of cattle. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2757–2761. doi: 10.1073/pnas.91.7.2757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MacHugh D. E., Shriver M. D., Loftus R. T., Cunningham P., Bradley D. G. Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus). Genetics. 1997 Jul;146(3):1071–1086. doi: 10.1093/genetics/146.3.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marklund S., Chaudhary R., Marklund L., Sandberg K., Andersson L. Extensive mtDNA diversity in horses revealed by PCR-SSCP analysis. Anim Genet. 1995 Jun;26(3):193–196. doi: 10.1111/j.1365-2052.1995.tb03162.x. [DOI] [PubMed] [Google Scholar]
  14. Okumura N., Ishiguro N., Nakano M., Hirai K., Matsui A., Sahara M. Geographic population structure and sequence divergence in the mitochondrial DNA control region of the Japanese wild boar (Sus scrofa leucomystax), with reference to those of domestic pigs. Biochem Genet. 1996 Jun;34(5-6):179–189. doi: 10.1007/BF02407018. [DOI] [PubMed] [Google Scholar]
  15. Paszek A. A., Flickinger G. H., Fontanesi L., Beattie C. W., Rohrer G. A., Alexander L., Schook L. B. Evaluating evolutionary divergence with microsatellites. J Mol Evol. 1998 Jan;46(1):121–126. doi: 10.1007/pl00006279. [DOI] [PubMed] [Google Scholar]
  16. Rohrer G. A., Keele J. W. Identification of quantitative trait loci affecting carcass composition in swine: I. Fat deposition traits. J Anim Sci. 1998 Sep;76(9):2247–2254. doi: 10.2527/1998.7692247x. [DOI] [PubMed] [Google Scholar]
  17. Ursing B. M., Arnason U. The complete mitochondrial DNA sequence of the pig (Sus scrofa). J Mol Evol. 1998 Sep;47(3):302–306. doi: 10.1007/pl00006388. [DOI] [PubMed] [Google Scholar]
  18. Vilà C., Savolainen P., Maldonado J. E., Amorim I. R., Rice J. E., Honeycutt R. L., Crandall K. A., Lundeberg J., Wayne R. K. Multiple and ancient origins of the domestic dog. Science. 1997 Jun 13;276(5319):1687–1689. doi: 10.1126/science.276.5319.1687. [DOI] [PubMed] [Google Scholar]
  19. Ward R. H., Frazier B. L., Dew-Jager K., Päbo S. Extensive mitochondrial diversity within a single Amerindian tribe. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8720–8724. doi: 10.1073/pnas.88.19.8720. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Watanabe T., Hayashi Y., Kimura J., Yasuda Y., Saitou N., Tomita T., Ogasawara N. Pig mitochondrial DNA: polymorphism, restriction map orientation, and sequence data. Biochem Genet. 1986 Jun;24(5-6):385–396. doi: 10.1007/BF00499094. [DOI] [PubMed] [Google Scholar]

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