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. 2000 Jun;155(2):989–992. doi: 10.1093/genetics/155.2.989

A glucose transporter chimera confers a dominant negative glucose starvation phenotype in Saccharomyces cerevisiae.

P W Sherwood 1, I Katic 1, P Sanz 1, M Carlson 1
PMCID: PMC1461109  PMID: 10835416

Abstract

A family of glucose transporters mediates glucose uptake in Saccharomyces cerevisiae. We show that the dominant mutation GSF4-1, which impairs glucose repression of SUC2, results in a nonfunctional chimera of the transporters Hxt1p and Hxt4p. Hxt1/4p inhibits the function of wild-type glucose transporters. Similar mutations may facilitate analysis of the major facilitator superfamily.

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Selected References

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