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. 2002 Apr;160(4):1745–1747. doi: 10.1093/genetics/160.4.1745

The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders.

Amar J S Klar 1
PMCID: PMC1462039  PMID: 11973326

Abstract

Genetics is assumed to cause susceptibility to psychosis, but no major locus has been identified. These disorders cosegregate with a chromosome 1;11 translocation in a Scottish pedigree where 50% of the carriers are diseased. A genetic model originally proposed to explain the basis of these illnesses predicts such an outcome.

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Selected References

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