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. 2003 Feb;163(2):803–810. doi: 10.1093/genetics/163.2.803

The coalescent and infinite-site model of a small multigene family.

Hideki Innan 1
PMCID: PMC1462437  PMID: 12618415

Abstract

The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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