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. 1984 Apr;17(4):465–469. doi: 10.1111/j.1365-2125.1984.tb02373.x

A rapid method for determination of acetylation phenotype using dapsone.

P A Philip, M S Roberts, H J Rogers
PMCID: PMC1463405  PMID: 6721993

Abstract

A rapid, simple one-stage protein precipitation method for the estimation of plasma dapsone (DDS) and monoacetyldapsone (MADDS) concentration by high-pressure liquid chromatography (h.p.l.c.) is described. Its performance in the assignment of acetylator phenotype was compared with a reference h.p.l.c. method utilising an extraction procedure and internal standard. The rapid h.p.l.c. technique combined with measurement of the plasma MADDS/DDS ratio is, in our opinion, the method of choice for the determination of the acetylator phenotype in population studies.

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Selected References

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