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. 1984;18(Suppl 2):163S–167S. doi: 10.1111/j.1365-2125.1984.tb02594.x

Enalapril in heart failure

M G Nicholls, H Ikram, E A Espiner, M W I Webster, M A Fitzpatrick
PMCID: PMC1463468  PMID: 6099733

Abstract

1 Serum MK-422 and plasma angiotensin converting enzyme activity were measured during the introduction of enalapril therapy in eight patients with heart failure. In a second study of 16 patients, we recorded exercise tolerance, clinical status and haemodynamics before and after 12 weeks of placebo or enalapril treatment.

2 Increasing doses of enalapril gave step-wise increments in serum MK-422. Plasma converting enzyme activity remained low for at least 24 h after each dose of enalapril (5, 10 and 20 mg).

3 Compared to placebo patients (n = 8), those receiving enalapril (n = 8) tended to improve their exercise performance and clinical status, and showed a fall in right heart pressures after 12 weeks of treatment.

Keywords: heart failure, enalapril, converting enzyme

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Selected References

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