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. 1985;19(Suppl 2):97S–105S. doi: 10.1111/j.1365-2125.1985.tb02749.x

Investigation of drug absorption from the gastrointestinal tract of man

I. Metoprolol in the stomach, duodenum and jejunum

G Jobin, A Cortot, J Godbillon, M Duval, J P Schoeller, J Hirtz, J J Bernier
PMCID: PMC1463760  PMID: 4005135

Abstract

1 Gastrointestinal (GI) absorption of the β-adrenoceptor blocker metoprolol was investigated in five healthy subjects by means of an intubation method, employing a triple-lumen tube introduced into the intestine, and a twin-lumen tube in the stomach. Metoprolol was introduced into the stomach with a homogenized meal containing a non-absorbable marker, [14C]-PEG 4000, and another marker, PEG 4000, was perfused continuously into the duodenum just below the pylorus. Samples of GI contents were collected at regular intervals over 4 h in the stomach and at two different levels in the upper small intestine.

2 Metoprolol was not absorbed from the stomach. Approximately 60% of the amount of drug emptied from the stomach was absorbed from the duodenum; about 50% of that leaving the duodenum was absorbed from the first part of the jejunum. The delivery process was the rate-limiting factor of metoprolol absorption in these segments of the gut.

3 Plasma concentrations reflected drug loss from the lumen and were higher in subjects exhibiting faster gastric emptying and higher absorption rates in the duodenum and jejunum.

4 The intubation technique appeared to be a suitable method for investigating drug absorption from the GI tract in man.

Keywords: drug absorption, metoprolol, stomach, duodenum, jejunum

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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