Abstract
Fuzzy adaptive least-squares (FALS), a pattern recognition method recently developed in our laboratory for correlating structure with activity rating, was used to generate quantitative structure-activity relationship (QSAR) models on the carcinogenicity of organic compounds of several chemical classes. Using the predictive models obtained from the chemical class-based FALS QSAR approach, the rodent carcinogenicity or noncarcinogenicity of a group of organic chemicals currently being tested by the U.S. National Toxicology Program was estimated from their chemical structures.
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Selected References
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- Ashby J., Tennant R. W. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat Res. 1991 May;257(3):229–306. doi: 10.1016/0165-1110(91)90003-e. [DOI] [PubMed] [Google Scholar]
- Gold L. S., Manley N. B., Slone T. H., Garfinkel G. B., Ames B. N., Rohrbach L., Stern B. R., Chow K. Sixth plot of the carcinogenic potency database: results of animal bioassays published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993. Environ Health Perspect. 1995 Nov;103 (Suppl 8):3–122. doi: 10.1289/ehp.95103s83. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matsushita S., Yamada S., Kudoh Y. [Shigella dysenteriae strains having a provisional serovar isolated from imported diarrheal cases in Tokyo]. Kansenshogaku Zasshi. 1992 Jul;66(7):930–934. doi: 10.11150/kansenshogakuzasshi1970.66.930. [DOI] [PubMed] [Google Scholar]
- Richard A. M. International Commission for Protection Against Environmental Mutagens and Carcinogens. Application of SAR methods to non-congeneric data bases associated with carcinogenicity and mutagenicity: issues and approaches. Mutat Res. 1994 Feb 1;305(1):73–97. doi: 10.1016/0027-5107(94)90127-9. [DOI] [PubMed] [Google Scholar]
- Yamamura E., Hirono H., Takeuchi M., Kojima M., Aoki S. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides with triethylenemelamine. Mutat Res. 1992 Feb-Mar;278(2-3):127–130. [PubMed] [Google Scholar]