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. 1978 Apr;22(1):131–137. doi: 10.1016/S0006-3495(78)85478-2

Effects of ammonium and bicarbonate-CO2 on intracellular chloride levels in Aplysia neurons.

J M Russell
PMCID: PMC1473400  PMID: 25096

Abstract

The level of intracellular free chloride in Aplysia giant neurons can be made to decline by pretreatment with 50 mM NH4+ solution followed by washing with 10 mM HCO3-/0.4% CO2-containing fluids. This effect can be completely blocked by the anion flux inhibitor, 4-acetamido-4'-isothiocyano-stilbene-2,2'-disulfonic acid (SITS). The net change of free chloride in the cell cannot be explained by changes in the electrochemical gradient of chloride. These results support the hypothesis that at least one mechanism for intracellular pH regulation involves a Cl-/HCO-3 exchange process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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