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. 1987 Aug;73:77–90. doi: 10.1289/ehp.877377

Ovarian neoplasia in the Sprague-Dawley rat.

D J Lewis 1
PMCID: PMC1474550  PMID: 2822382

Abstract

Macroscopic and microscopic characteristics of 210 spontaneous ovarian tumors from 7748 Sprague-Dawley rats are described. The tumors were classified as tubular adenoma, anaplastic adenocarcinoma, papillary cystadenoma, papillary cystadenocarcinoma, mesothelioma, sertoliform tubular adenoma, Sertoli's cell tumor, granulosa cell tumor, thecal cell tumor, polycystic sex cord/stromal tumor, and lipoid cell tumor. The histogenesis of the tumor types is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aschheim P. A biological aging test for the central regulation of the estrous cycle in the rat. Its first application. Experientia. 1974 Feb 15;30(2):213–213. [PubMed] [Google Scholar]
  2. Attia M. A. Neoplastic and nonneoplastic lesions in aging female rats with special reference to the functional morphology of the hyperplastic and neoplastic changes in the pituitary gland. Arch Toxicol. 1985 Jun;57(2):77–83. doi: 10.1007/BF00343114. [DOI] [PubMed] [Google Scholar]
  3. BOOT L. M., MUHLBOCK O., THUNG P. J. Senile changes in the oestrous cycle and in ovarian structure in some inbred strains of mice. Acta Endocrinol (Copenh) 1956 Sep;23(1):8–32. doi: 10.1530/acta.0.0230008. [DOI] [PubMed] [Google Scholar]
  4. Carter R. L. Pathology of ovarian neoplasms in rats and mice. Eur J Cancer. 1968 Jan;3(6):537–543. doi: 10.1016/0014-2964(68)90092-3. [DOI] [PubMed] [Google Scholar]
  5. Crumeyrolle-Arias M., Scheib D., Aschheim P. Light and electron microscopy of the ovarian interstitial tissue in the senile rat: normal aspect and response to HCG of "deficiency cells' and 'epithelial cords'. Gerontology. 1976;22(3):185–204. doi: 10.1159/000212133. [DOI] [PubMed] [Google Scholar]
  6. Cummins P. A., Fox H., Langley F. A. An electron-microscopic study of the endometrioid adenocarcinoma of the ovary and a comparison of its fine structure with that of normal endometrium and of adenocarcinoma of the endometrium. J Pathol. 1974 Jul;113(3):165–173. doi: 10.1002/path.1711130306. [DOI] [PubMed] [Google Scholar]
  7. DEANE H. W., LOBEL B. L., ROMNEY S. L. Enzymic histochemistry of normal human ovaries of the menstrual cycle, pregnancy, and the early puerperium. Am J Obstet Gynecol. 1962 Feb 1;83:281–294. doi: 10.1016/s0002-9378(16)35833-1. [DOI] [PubMed] [Google Scholar]
  8. Dallenbach-Hellweg G. On the histogenesis and morphology of ovarian carcinomas. J Cancer Res Clin Oncol. 1984;107(2):71–80. doi: 10.1007/BF00399375. [DOI] [PubMed] [Google Scholar]
  9. Dehner L. P., Norris H. J., Garner F. M., Taylor H. B. Comparative pathology of ovarian neoplasms. 3. Germ cell tumours of canine, bovine, feline, rodent and human species. J Comp Pathol. 1970 Apr;80(2):299–306. doi: 10.1016/0021-9975(70)90098-8. [DOI] [PubMed] [Google Scholar]
  10. Demopoulos R. I., Kammerman S. Fine structural evidence on the origin of gonadotropin-induced ovarian tumors in mice. Cancer Res. 1981 Mar;41(3):871–876. [PubMed] [Google Scholar]
  11. Frith C. H., Zuna R. E., Morgan K. A morphologic classification and incidence of spontaneous ovarian neoplasms in three strains of mice. J Natl Cancer Inst. 1981 Sep;67(3):693–702. [PubMed] [Google Scholar]
  12. Fukunishi R., Wang H., Yoshida A., Yoshida H., Hirota N. Induction of ovarian tumor in rats with N-butylnitrosourea. Gan. 1975 Jun;66(3):323–325. [PubMed] [Google Scholar]
  13. Gregson R. L., Lewis D. J., Abbott D. P. Spontaneous ovarian neoplasms of the laboratory rat. Vet Pathol. 1984 May;21(3):292–299. doi: 10.1177/030098588402100305. [DOI] [PubMed] [Google Scholar]
  14. Hamlett J. D., Aparicio S. R., Lumsden C. E. Light- and electron-microscope studies on experimentally induced tumours of the theca-granulosa cell series in the mouse. J Pathol. 1971 Oct;105(2):111–124. doi: 10.1002/path.1711050205. [DOI] [PubMed] [Google Scholar]
  15. Haseman J. K., Huff J., Boorman G. A. Use of historical control data in carcinogenicity studies in rodents. Toxicol Pathol. 1984;12(2):126–135. doi: 10.1177/019262338401200203. [DOI] [PubMed] [Google Scholar]
  16. Knowles J. F. Cancer of rat ovaries: Sertoli cell or granulosa-theca cell tumours? Br J Cancer. 1983 Aug;48(2):301–305. doi: 10.1038/bjc.1983.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lingeman C. H. Etiology of cancer of the human ovary: a review. J Natl Cancer Inst. 1974 Dec;53(6):1603–1618. [PubMed] [Google Scholar]
  18. Murphy E. D. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst. 1972 May;48(5):1283–1295. [PubMed] [Google Scholar]
  19. Nielsen S. W., Misdorp W., McEntee K. Tumours of the ovary. Bull World Health Organ. 1976;53(2-3):203–215. [PMC free article] [PubMed] [Google Scholar]
  20. Norris H. J., Garner F. M., Taylor H. B. Comparative pathology of ovarian neoplasms. IV. Gonadal stromal tumours of canine species. J Comp Pathol. 1970 Jul;80(3):399–405. doi: 10.1016/0021-9975(70)90070-8. [DOI] [PubMed] [Google Scholar]
  21. Parmley T. H., Woodruff J. D. The ovarian mesothelioma. Am J Obstet Gynecol. 1974 Sep 15;120(2):234–241. doi: 10.1016/0002-9378(74)90370-6. [DOI] [PubMed] [Google Scholar]
  22. Ratcliffe H. L. Spontaneous tumors in two colonies of rats of the Wistar Institute of Anatomy and Biology. Am J Pathol. 1940 May;16(3):237–254.1. [PMC free article] [PubMed] [Google Scholar]
  23. Rehm S., Dierksen D., Deerberg F. Spontaneous ovarian tumors in Han:NMRI mice: histologic classification, incidence, and influence of food restriction. J Natl Cancer Inst. 1984 Jun;72(6):1383–1395. [PubMed] [Google Scholar]
  24. Russell P. The pathological assessment of ovarian neoplasms. III: The malignant "epithelial" tumours. Pathology. 1979 Jul;11(3):493–532. doi: 10.3109/00313027909059027. [DOI] [PubMed] [Google Scholar]
  25. Scully R. E. Ovarian tumors. A review. Am J Pathol. 1977 Jun;87(3):686–720. [PMC free article] [PubMed] [Google Scholar]
  26. Sekiya S., Endoh N., Kikuchi Y., Katoh T., Matsuura A., Iwasawa H., Takeda B., Takamizawa H. In vivo and in vitro studies of experimental ovarian adenocarcinoma in rats. Cancer Res. 1979 Mar;39(3):1108–1112. [PubMed] [Google Scholar]
  27. VON NUMERS OBSERVATIONS ON METAPLASTIC CHANGES IN THE GERMINAL EPITHELIUM OF THE OVARY AND ON THE AETIOLOGY OF OVARIAN ENDOMETRIOSIS. Acta Obstet Gynecol Scand. 1965;44:107–116. doi: 10.3109/00016346509153982. [DOI] [PubMed] [Google Scholar]
  28. Young R. H., Scully R. E. Ovarian Sertoli cell tumors: a report of 10 cases. Int J Gynecol Pathol. 1984;2(4):349–363. doi: 10.1097/00004347-198404000-00003. [DOI] [PubMed] [Google Scholar]

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