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. 1986 Mar;65:243–248. doi: 10.1289/ehp.8665243

Effects of phthalic acid esters (PAEs) on the neonate and aspects of teratogenic actions.

J A Thomas, D B Wienckowski, B A Gillies, M J Thomas, E J Youkilis
PMCID: PMC1474722  PMID: 3709448

Abstract

A review of the literature reveals that several different phthalic acid esters (PAEs) are capable of causing testicular damage. Phthalate-induced zinc deficiency is consistent with germinal epithelial damage. Among experimental animals, mice perhaps show the greatest sensitivity to phthalate-induced terata, but high doses/exposure are required. Little toxicologic information is available with regard to phthalate-induced effects upon the neonate.

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Selected References

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