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. 1976 Aug;16:127–138. doi: 10.1289/ehp.7616127

Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol.

M R Boyd
PMCID: PMC1475220  PMID: 1017416

Abstract

Many xenobiotics produce hepatic injury due to their metabolism in the liver to highly reactive electrophile intermediates which form covalent conjugates with nucleophilic cellular constituents. This presentation describes studies indicating that the production of chemically reactive metabolites by pulmonary metabolism of xenobiotics can also play a fundamental role in the pathogenesis of chemically induced lung disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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