Skip to main content
PMC home page
The Canadian Veterinary Journal logoLink to The Canadian Veterinary Journal
. 2001 Jun;42(6):461–464.

Lack of antibodies to porcine circovirus type 2 virus in beef and dairy cattle and horses in western Canada.

J A Ellis 1, C Konoby 1, K H West 1, G M Allan 1, S Krakowka 1, F McNeilly 1, B Meehan 1, I Walker 1
PMCID: PMC1476552  PMID: 11424578

Abstract

Porcine circovirus type 2 (PCV2) is a recently recognized agent that is consistently associated with postweaning multisystemic wasting disease in swine. There are conflicting data concerning the ability of this virus to infect and cause disease in other species. To determine if normal cattle, cattle affected with various illnesses, and normal horses in endemic areas of PCV2 infection in swine have had PCV2 infections, 100 randomly selected bovine sera, 100 equine sera, and 100 colostrum samples from clinically normal dairy cattle were examined for the presence of antibodies to porcine circoviruses by using ELISAs. All samples tested were negative for antibodies to porcine circoviruses. As well, a seronegative neonatal Holstein calf and 6 seronegative, 6-month-old beef calves that were experimentally infected with PCV2 failed to develop antibodies to the virus. These results suggest that natural infection of cattle and horses with PCV2 does not occur, or is a rare event, in western Canada.

Full text

PDF
464

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allan G. M., Ellis J. A. Porcine circoviruses: a review. J Vet Diagn Invest. 2000 Jan;12(1):3–14. doi: 10.1177/104063870001200102. [DOI] [PubMed] [Google Scholar]
  2. Allan G. M., McNeilly F., Kennedy S., Daft B., Clarke E. G., Ellis J. A., Haines D. M., Meehan B. M., Adair B. M. Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. J Vet Diagn Invest. 1998 Jan;10(1):3–10. doi: 10.1177/104063879801000102. [DOI] [PubMed] [Google Scholar]
  3. Allan G. M., McNeilly F., McNair I., Curran M. D., Walker I., Ellis J., Konoby C., Kennedy S., Meehan B. Absence of evidence for porcine circovirus type 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep. Arch Virol. 2000;145(4):853–857. doi: 10.1007/s007050050678. [DOI] [PubMed] [Google Scholar]
  4. Allan G. M., Phenix K. V., Todd D., McNulty M. S. Some biological and physico-chemical properties of porcine circovirus. Zentralbl Veterinarmed B. 1994 Mar;41(1):17–26. doi: 10.1111/j.1439-0450.1994.tb00201.x. [DOI] [PubMed] [Google Scholar]
  5. Allan G., Meehan B., Todd D., Kennedy S., McNeilly F., Ellis J., Clark E. G., Harding J., Espuna E., Botner A. Novel porcine circoviruses from pigs with wasting disease syndromes. Vet Rec. 1998 Apr 25;142(17):467–468. [PubMed] [Google Scholar]
  6. Choi C., Chae C., Clark E. G. Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction. J Vet Diagn Invest. 2000 Mar;12(2):151–153. doi: 10.1177/104063870001200209. [DOI] [PubMed] [Google Scholar]
  7. Ellis J. A., Wiseman B. M., Allan G., Konoby C., Krakowka S., Meehan B. M., McNeilly F. Analysis of seroconversion to porcine circovirus 2 among veterinarians from the United States and Canada. J Am Vet Med Assoc. 2000 Dec 1;217(11):1645–1646. doi: 10.2460/javma.2000.217.1645. [DOI] [PubMed] [Google Scholar]
  8. Ellis J., Hassard L., Clark E., Harding J., Allan G., Willson P., Strokappe J., Martin K., McNeilly F., Meehan B. Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can Vet J. 1998 Jan;39(1):44–51. [PMC free article] [PubMed] [Google Scholar]
  9. Ellis J., Krakowka S., Lairmore M., Haines D., Bratanich A., Clark E., Allan G., Konoby C., Hassard L., Meehan B. Reproduction of lesions of postweaning multisystemic wasting syndrome in gnotobiotic piglets. J Vet Diagn Invest. 1999 Jan;11(1):3–14. doi: 10.1177/104063879901100101. [DOI] [PubMed] [Google Scholar]
  10. Krakowka S., Ellis J. A., McNeilly F., Ringler S., Rings D. M., Allan G. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet Pathol. 2001 Jan;38(1):31–42. doi: 10.1354/vp.38-1-31. [DOI] [PubMed] [Google Scholar]
  11. Meehan B. M., McNeilly F., Todd D., Kennedy S., Jewhurst V. A., Ellis J. A., Hassard L. E., Clark E. G., Haines D. M., Allan G. M. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. J Gen Virol. 1998 Sep;79(Pt 9):2171–2179. doi: 10.1099/0022-1317-79-9-2171. [DOI] [PubMed] [Google Scholar]
  12. Morozov I., Sirinarumitr T., Sorden S. D., Halbur P. G., Morgan M. K., Yoon K. J., Paul P. S. Detection of a novel strain of porcine circovirus in pigs with postweaning multisystemic wasting syndrome. J Clin Microbiol. 1998 Sep;36(9):2535–2541. doi: 10.1128/jcm.36.9.2535-2541.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nayar G. P., Hamel A. L., Lin L., Sachvie C., Grudeski E., Spearman G. Evidence for circovirus in cattle with respiratory disease and from aborted bovine fetuses. Can Vet J. 1999 Apr;40(4):277–278. [PMC free article] [PubMed] [Google Scholar]
  14. Segalés J., Sitjar M., Domingo M., Dee S., Del Pozo M., Noval R., Sacristan C., De las Heras A., Ferro A., Latimer K. S. First report of post-weaning multisystemic wasting syndrome in pigs in Spain. Vet Rec. 1997 Dec 6;141(23):600–601. [PubMed] [Google Scholar]
  15. Tischer I., Bode L., Apodaca J., Timm H., Peters D., Rasch R., Pociuli S., Gerike E. Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle. Arch Virol. 1995;140(8):1427–1439. doi: 10.1007/BF01322669. [DOI] [PubMed] [Google Scholar]
  16. Tischer I., Gelderblom H., Vettermann W., Koch M. A. A very small porcine virus with circular single-stranded DNA. Nature. 1982 Jan 7;295(5844):64–66. doi: 10.1038/295064a0. [DOI] [PubMed] [Google Scholar]
  17. Walker I. W., Konoby C. A., Jewhurst V. A., McNair I., McNeilly F., Meehan B. M., Cottrell T. S., Ellis J. A., Allan G. M. Development and application of a competitive enzyme-linked immunosorbent assay for the detection of serum antibodies to porcine circovirus type 2. J Vet Diagn Invest. 2000 Sep;12(5):400–405. doi: 10.1177/104063870001200502. [DOI] [PubMed] [Google Scholar]

Articles from The Canadian Veterinary Journal are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES