Abstract
A field trial was performed to compare trimethoprim-sulfadoxine to ceftiofur sodium in the treatment of bovine respiratory disease (BRD) in feedlot calves. Five-hundred-and-fifty-five recently weaned, crossbred beef calves, with naturally occurring cases of BRD, were randomly assigned to either trimethoprim-sulfadoxine or ceftiofur sodium treatment groups. The effectiveness of the antibiotics was assessed by comparing relapse rates, three day treatment response rates, mortality rates, chronicity rates, and wastage rates. There was no statistical difference in the first or second relapse rates between the two groups. For the initial therapy, first relapses, and overall treatment episodes, a significantly greater proportion of the calves treated with ceftiofur sodium responded to three days of therapy than those treated with trimethoprim-sulfadoxine (p < 0.05). This resulted in a 10% reduction in treatment costs for calves in the ceftiofur group. There were significantly lower mortality and wastage rates attributable to BRD in the ceftiofur sodium group than in the trimethoprim-sulfadoxine group (p < 0.05). However, there were no significant differences in overall mortality, overall chronicity, or overall wastage rates between the treatment groups.
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- Bateman K. G., Martin S. W., Shewen P. E., Menzies P. I. An evaluation of antimicrobial therapy for undifferentiated bovine respiratory disease. Can Vet J. 1990 Oct;31(10):689–696. [PMC free article] [PubMed] [Google Scholar]
- Church T. L., Radostits O. M. A retrospective survey of diseases of feedlot cattle in Alberta. Can Vet J. 1981 Feb;22(2):27–30. [PMC free article] [PubMed] [Google Scholar]
- Fales W. H., Selby L. A., Webber J. J., Hoffman L. J., Kintner L. D., Nelson S. L., Miller R. B., Thorne J. G., McGinity J. T., Smith D. K. Antimicrobial resistance among Pasteurella spp recovered from Missouri and Iowa cattle with bovine respiratory disease complex. J Am Vet Med Assoc. 1982 Sep 1;181(5):477–479. [PubMed] [Google Scholar]
- Frank G. H. Pasteurella haemolytica and respiratory disease in cattle. Proc Annu Meet U S Anim Health Assoc. 1979;(83):153–160. [PubMed] [Google Scholar]
- Greenwood D. In vitro veritas? Antimicrobial susceptibility tests and their clinical relevance. J Infect Dis. 1981 Oct;144(4):380–385. doi: 10.1093/infdis/144.4.380. [DOI] [PubMed] [Google Scholar]
- Hjerpe C. A. Clinical management of respiratory disease in feedlot cattle. Vet Clin North Am Large Anim Pract. 1983 Mar;5(1):119–142. doi: 10.1016/s0196-9846(17)30096-4. [DOI] [PubMed] [Google Scholar]
- Jensen R., Pierson R. E., Braddy P. M., Saari D. A., Lauerman L. H., England J. J., Keyvanfar H., Collier J. R., Horton D. P., McChesney A. E. Shipping fever pneumonia in yearling feedlot cattle. J Am Vet Med Assoc. 1976 Sep 1;169(5):500–506. [PubMed] [Google Scholar]
- Martin S. W., Meek A. H., Curtis R. A. Antimicrobial use in feedlot calves: its association with culture rates and antimicrobial susceptibility. Can J Comp Med. 1983 Jan;47(1):6–10. [PMC free article] [PubMed] [Google Scholar]
- Martin S. W., Meek A. H., Davis D. G., Thomson R. G., Johnson J. A., Lopez A., Stephens L., Curtis R. A., Prescott J. F., Rosendal S. Factors associated with mortality in feedlot cattle: the Bruce County Beef Cattle Project. Can J Comp Med. 1980 Jan;44(1):1–10. [PMC free article] [PubMed] [Google Scholar]
- Mechor G. D., Jim G. K., Janzen E. D. Comparison of penicillin, oxytetracycline, and trimethoprim-sulfadoxine in the treatment of acute undifferentiated bovine respiratory disease. Can Vet J. 1988 May;29(5):438–443. [PMC free article] [PubMed] [Google Scholar]
- Woolcock J. B., Mutimer M. D. Antibiotic susceptibility testing: caeci caecos ducentes? Vet Rec. 1983 Aug 6;113(6):125–128. doi: 10.1136/vr.113.6.125. [DOI] [PubMed] [Google Scholar]
- Yates W. D. A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Can J Comp Med. 1982 Jul;46(3):225–263. [PMC free article] [PubMed] [Google Scholar]