Abstract
Murexine (urocanoylcholine, [2-β-imidazol-4(5)-ylacryloyloxyethyl] trimethylammonium bromide) has been shown to possess ganglion stimulating and neuromuscular blocking actions in cat, dog and rat. The blockade has been shown to be of the depolarizing type both on the basis of the resemblance of the pharmacological properties of the substance to that of known depolarizing blocking agents, and also directly by recording the depolarization produced in the endplate region of the gracilis muscle of the rat.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BURNS B. D., PATON W. D. M. Depolarization of the motor end-plate by decamethonium and acetylcholine. J Physiol. 1951 Sep;115(1):41–73. doi: 10.1113/jphysiol.1951.sp004652. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FOLDES F. F., ERDOS E. G., BAART N., SHANOR S. P. Interrelationship of murexine, dihydromurexine and human cholinesterases. Proc Soc Exp Biol Med. 1957 Mar;94(3):500–503. doi: 10.3181/00379727-94-22991. [DOI] [PubMed] [Google Scholar]
- GRELIS M. E., TABACHNICK I. I. The enzymatic hydrolysis of imidazoleacryloylcholine (murexine) and imidazolepropionylcholine (dihydromurexine) by various cholinesterases. Br J Pharmacol Chemother. 1957 Sep;12(3):320–322. doi: 10.1111/j.1476-5381.1957.tb00141.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KENSLER C. J., LANGEMANN H., ZIRKLE C. L. The cholinergic activity of tetrakis-(dimethylaminomethyl)-methane tetramethobromide. J Pharmacol Exp Ther. 1954 Feb;110(2):127–134. [PubMed] [Google Scholar]
- KEYL M. J., MICHAELSON I. A., WHITTAKER V. P. Physiologically active choline esters in certain marine gastropods and other invertebrates. J Physiol. 1957 Dec 31;139(3):434–454. doi: 10.1113/jphysiol.1957.sp005903. [DOI] [PMC free article] [PubMed] [Google Scholar]
- QUILLIAM J. P. The mechanism of action of murexine on neuromuscular transmission in the frog. Br J Pharmacol Chemother. 1957 Sep;12(3):388–392. doi: 10.1111/j.1476-5381.1957.tb00153.x. [DOI] [PMC free article] [PubMed] [Google Scholar]