Abstract
If small doses of histamine are alternated with small doses of acetylcholine on the isolated guinea-pig ileum in Tyrode solution, the response to histamine tends to diminish and may disappear. When the response to the small doses of histamine has disappeared, a contraction may be elicited by larger doses. The diminution is reversible, the response returning if the preparation is left unstimulated by drugs for varying periods of time. This phenomenon also occurs when the loops are suspended in Tyrode solution containing cocaine or atropine.
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Selected References
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- AMBACHE N., LESSIN A. W. Classification of intestinomotor drugs by means of type D botulinum toxin. J Physiol. 1955 Mar 28;127(3):449–478. doi: 10.1113/jphysiol.1955.sp005270. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURN J. H. Action of local hormones: introduction. Proc R Soc Lond B Biol Sci. 1950 Oct 13;137(888):281–285. [PubMed] [Google Scholar]
- Bülbring E., Burn J. H. Action of acetylcholine on rabbit auricles in relation to acetylcholine synthesis. J Physiol. 1949 Jun 15;108(4):508–524. [PMC free article] [PubMed] [Google Scholar]
- FELDBERG W. S. On the origin and function of the acetylcholine in the intestinal wall. Proc R Soc Lond B Biol Sci. 1950 Oct 13;137(888):285–292. doi: 10.1098/rspb.1950.0037. [DOI] [PubMed] [Google Scholar]