Abstract
The response to neuromuscular blocking agents, as exemplified by suxamethonium and tubocurarine, may differ between symmetrical muscles. Increased rates of stimulation and fatigue both increase sensitivity to blocking agents. During recovery from suxamethonium block muscles may show a transitory failure to react to each stimulus with a contraction. Fatigue caused by prolonged indirect stimulation is prevented equally well by suxamethonium and tubocurarine in doses producing a complete block. The mechanism and significance of these findings are discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHURCHILL-DAVIDSON H. C. Suxamethonium (succinylcholine) chloride and muscle pains. Br Med J. 1954 Jan 9;1(4853):74–75. doi: 10.1136/bmj.1.4853.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cooper S. The isometric responses of mammalian muscles. J Physiol. 1930 Jun 27;69(4):377–385. doi: 10.1113/jphysiol.1930.sp002657. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EDWARDS R. G., LIPPOLD O. C. The relation between force and integrated electrical activity in fatigued muscle. J Physiol. 1956 Jun 28;132(3):677–681. doi: 10.1113/jphysiol.1956.sp005558. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GUYTON A. C., REEDER R. C. The dynamics of curarization. J Pharmacol Exp Ther. 1949 Nov;97(3):322–330. [PubMed] [Google Scholar]
- LILEY A. W., NORTH K. A. An electrical investigation of effects of repetitive stimulation on mammalian neuromuscular junction. J Neurophysiol. 1953 Sep;16(5):509–527. doi: 10.1152/jn.1953.16.5.509. [DOI] [PubMed] [Google Scholar]
- LI T. H., JACOBS B. R., AVIADO D. M., Jr, SCHMIDT C. F. Early respiratory depression by curare and curarepotassium antagonism. J Pharmacol Exp Ther. 1952 Feb;104(2):149–161. [PubMed] [Google Scholar]
- MERTON P. A. Voluntary strength and fatigue. J Physiol. 1954 Mar 29;123(3):553–564. doi: 10.1113/jphysiol.1954.sp005070. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PATON W. D. The principles of neuromusclular block. Anaesthesia. 1953 Jul;8(3):151–174. doi: 10.1111/j.1365-2044.1953.tb01902.x. [DOI] [PubMed] [Google Scholar]
- PRESTON J. B., VAN MAANEN E. F. Effects of frequency of stimulation on the paralyzing dose of neuromuscular blocking agents. J Pharmacol Exp Ther. 1953 Feb;107(2):165–171. [PubMed] [Google Scholar]