Abstract
The action of diacetyl monoxime on neuromuscular transmission has been studied in frogs, chickens, and cats, and in isolated rat phrenic nerve-diaphragm preparations. In frogs and chickens the oxime caused a flaccid paralysis; in chickens there was sometimes opisthotonos. In the indirectly stimulated rat diaphragm, diacetyl monoxime decreased the height of a single twitch, but a tetanus was well sustained. In cats, the twitch height of the indirectly excited gastrocnemius-soleus muscle was reduced by diacetyl monoxime more than was that of the tibialis anterior muscle, but in both muscles a tetanus was well maintained. Diacetyl monoxime reduced the response to direct stimulation of both the rat diaphragm and cat muscles. Diacetyl monoxime injected intra-arterially in the cat elicited a transient hypertension and a gasp. Diacetyl monoxime did not reverse the neuromuscular block caused by anticholinesterases either in isolated rat phrenic nerve-diaphragm preparations or in cats.
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Selected References
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- EDERY H., SCHATZBERG-PORATH G. Pyridine-2-aldoxime methiodide and diacetyl monoxime against organophosphorus poisoning. Science. 1958 Nov 7;128(3332):1137–1138. doi: 10.1126/science.128.3332.1137. [DOI] [PubMed] [Google Scholar]
- GROB D., JOHNS R. J. Treatment of anticholinesterase intoxication with oximes; use in normal subjects and in patients with myasthenia gravis. J Am Med Assoc. 1958 Apr 12;166(15):1855–1858. doi: 10.1001/jama.1958.62990150001011. [DOI] [PubMed] [Google Scholar]
- HOLMES R., ROBINS E. L. The reversal by oximes of neuromuscular block produced by anticholinesterases. Br J Pharmacol Chemother. 1955 Dec;10(4):490–495. doi: 10.1111/j.1476-5381.1955.tb00110.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JAGER B. V., STAGG G. N. Toxicity of diacetyl monoxime and of pyridine-2-aldoxime methiodide in man. Bull Johns Hopkins Hosp. 1958 Apr;102(4):203–211. [PubMed] [Google Scholar]
- WAGLEY P. F. A study of end-plate potentials. II. Observations on the actions of certain oximes. Bull Johns Hopkins Hosp. 1957 Jun;100(6):287–293. [PubMed] [Google Scholar]
- WILLS J. H., KUNKEL A. M., BROWN R. V., GROBLEWSKI G. E. Pyridine-2-aldoxime methiodide and poisoning by anticholinesterases. Science. 1957 Apr 19;125(3251):743–744. doi: 10.1126/science.125.3251.743. [DOI] [PubMed] [Google Scholar]