Abstract
A new synthetic analogue of oxytocin with a phenylalanyl group instead of a tyrosyl group has been investigated. The most prominent biological properties of this peptide were its oxytocic activity on the rat or cat uterus in vivo and on milk-ejection pressure in the rabbit. Another remarkable feature was the striking difference in pressor activity measured in spinal cats and in anaesthetized rats. The presence of the phenylalanyl group in the molecule in the above-mentioned position did not increase the antidiuretic potency in unanaesthetized rats. The authors propose a nomenclature for the peptides related to oxytocin and vasopressin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERDE B., BOISSONNAS R. A., GUTTMANN S., JAQUENOUD P. A., KONZETT H., WALLER J. P. Synthesis and biological activity of a new potent analogue of oxytocin. Nature. 1956 Aug 4;178(4527):260–261. doi: 10.1038/178260a0. [DOI] [PubMed] [Google Scholar]
- BERDE B., CERLETTI A. Demonstration expérimentale de l'action de l'ocytocine sur la glande mammaire. Gynaecologia. 1957 Oct;144(4):275–278. [PubMed] [Google Scholar]
- BERDE B., DOEPFNER W., KONZETT H. Some pharmacological actions of four synthetic analogues of oxytocin. Br J Pharmacol Chemother. 1957 Jun;12(2):209–214. doi: 10.1111/j.1476-5381.1957.tb00121.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DEKANSKI J. The quantitative assay of vasopressin. Br J Pharmacol Chemother. 1952 Dec;7(4):567–572. doi: 10.1111/j.1476-5381.1952.tb00723.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KONZETT H., BERDE B., CERLETTI A. Syntocinon, ein synthetisches uteruswirksames Hypophysenhinterlappenhormon. Schweiz Med Wochenschr. 1956 Mar 3;86(9):226–229. [PubMed] [Google Scholar]
- RESSLER C., RACHELE J. R. Further properties of isoglutamine-oxytocin; inhibition of pressor activity of vasopressin. Proc Soc Exp Biol Med. 1958 May;98(1):170–174. doi: 10.3181/00379727-98-23978. [DOI] [PubMed] [Google Scholar]
- RESSLER C. The cyclic disulfide ring of oxytocin. Proc Soc Exp Biol Med. 1956 Aug-Sep;92(4):725–730. doi: 10.3181/00379727-92-22594. [DOI] [PubMed] [Google Scholar]
- SMYTH C. N. Effect of valyl-oxytocin on the human subject. Br Med J. 1958 Apr 12;1(5075):856–859. doi: 10.1136/bmj.1.5075.856. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schild H. O. A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine. J Physiol. 1942 Jun 2;101(1):115–130. doi: 10.1113/jphysiol.1942.sp003970. [DOI] [PMC free article] [PubMed] [Google Scholar]