Abstract
Several factors influencing the hypertensive effect of eserine in the rat were investigated. Pretreatment with reserpine regularly depressed or abolished the hypertensive response to eserine. The slow intravenous infusion of either noradrenaline, dihydroxyphenylalanine or 5-hydroxytryptamine only occasionally restored the hypertensive effect of eserine in reserpine-treated rats. Bretylium and choline 2,6-xylyl ether bromide significantly depressed or even abolished the hypertensive effect of eserine. The effect of bretylium was stronger than that of choline 2,6-xylyl ether bromide. Cocaine was found to antagonize the action of bretylium on the response to eserine. In doses which significantly depressed the action of eserine bretylium did not inhibit the hypertension due to excitation of medullary centres induced by clamping the common carotid arteries. Lowering of body temperature abolished the hypertensive effect of eserine. Pretreatment with isopropylisoniazid did not antagonize the inhibitory action of reserpine on the hypertensive response to eserine. It is concluded that the present experiments indicate that the hypertensive effect of eserine in the rat is due to central activation of adrenergic nervous elements. Liberation of noradrenaline (and adrenaline) from the adrenals and from the blood vessels by eserine is an insignificant factor in producing the hypertensive response to eserine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AVIADO D. M., DIL A. H. The effects of a new sympathetic blocking drug (bretylium) on cardiovascular control. J Pharmacol Exp Ther. 1960 Jul;129:328–337. [PubMed] [Google Scholar]
- BOURA A. L., GREEN A. F. The actions of bretylium: adrenergic neurone blocking and other effects. Br J Pharmacol Chemother. 1959 Dec;14:536–548. doi: 10.1111/j.1476-5381.1959.tb00961.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURN J. H., RAND M. J. Noradrenaline in artery walls and its dispersal by reserpine. Br Med J. 1958 Apr 19;1(5076):903–908. doi: 10.1136/bmj.1.5076.903. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURN J. H., RAND M. J. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314–336. doi: 10.1113/jphysiol.1958.sp006104. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DIRNHUBER P., CULLUMBINE H. The effect of anti-cholinesterase agents on the rat's blood pressure. Br J Pharmacol Chemother. 1955 Mar;10(1):12–15. doi: 10.1111/j.1476-5381.1955.tb00052.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HORNYKIEWICZ O., KOBINGER W. Uber den Einfluss von Eserin, Tetraäthylpyrophosphat (TEPP) und Neostigmin auf den Blutdruck und die pressorischen Carotissinusreflexe der Ratte. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1956;228(5):493–500. [PubMed] [Google Scholar]
- PLETSCHER A., SHORE P. A., BRODIE B. B. Serotonin as a mediator of reserpine action in brain. J Pharmacol Exp Ther. 1956 Jan;116(1):84–89. [PubMed] [Google Scholar]
- VARAGIC V. The action of eserine on the blood pressure of the rat. Br J Pharmacol Chemother. 1955 Sep;10(3):349–353. doi: 10.1111/j.1476-5381.1955.tb00882.x. [DOI] [PMC free article] [PubMed] [Google Scholar]