Skip to main content
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1961 Feb;16(1):15–22. doi: 10.1111/j.1476-5381.1961.tb00293.x

The effect of hexamethonium on the carotid chemoreceptor response to nicotine and cyanide

R Byck
PMCID: PMC1482015  PMID: 13689559

Abstract

The literature concerning the effects of ganglionic blocking agents on the chemoreceptors is reviewed. Hexamethonium blocks the respiratory response to intracarotid injections of small doses of nicotine in dogs anaesthetized with chloralose, but it does not block the response to sodium cyanide.

Full text

PDF
15

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DONTAS A. S., NICKERSON M. Effects of stimulants and of ganglionic blocking agents on carotid chemoreceptors. Arch Int Pharmacodyn Ther. 1956 May 1;106(3):312–331. [PubMed] [Google Scholar]
  2. DOUGLAS W. W. The effect of a ganglion-blocking drug, hexamethonium, on the response of the cat's carotid body to various stimuli. J Physiol. 1952 Nov;118(3):373–383. doi: 10.1113/jphysiol.1952.sp004801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FLOYD W. F., NEIL E. The influence of the sympathetic innervation of the carotid bifurcation on chemoceptor and baroceptor activity in the cat. Arch Int Pharmacodyn Ther. 1952 Sep 1;91(1-2):230–239. [PubMed] [Google Scholar]
  4. GOLLWITZER-MEIER K., WITZLEB E. Zur Wirkung bisquaternärer Ammoniumsalze auf das Glomus caroticum der Katze. Pflugers Arch. 1953;256(5):381–390. doi: 10.1007/BF00363685. [DOI] [PubMed] [Google Scholar]
  5. HEYMANS C., DELAUNOIS A. L., MARTINI L., JANSSEN P. The effect of certain autonomic drugs on the chemoreceptors of the carotid body and the baroreceptors of the carotid sinus. Arch Int Pharmacodyn Ther. 1953 Nov 1;96(2):209–219. [PubMed] [Google Scholar]
  6. LANDGREN S., LILJESTRAND G., ZOTTERMAN Y. The effect of certain autonomic drugs on the action potentials of the sinus nerve. Acta Physiol Scand. 1952 Sep 10;26(2-3):264–290. doi: 10.1111/j.1748-1716.1952.tb00909.x. [DOI] [PubMed] [Google Scholar]
  7. MONGE C., CORCORAN A. C., DEL GRECO F., PAGE I. H. Volume of distribution of hexamethonium in nephrectomized dogs. Am J Physiol. 1954 Aug;178(2):256–258. doi: 10.1152/ajplegacy.1954.178.2.256. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES