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. 1961 Dec;17(3):507–518. doi: 10.1111/j.1476-5381.1961.tb01137.x

Centrally acting muscle relaxants in tetanus

R A Webster
PMCID: PMC1482109  PMID: 14005498

Abstract

The anti-tetanus activity of a number of phenothiazine derivatives and other centrally acting muscle relaxants, such as mephenesin, dicyclopropyl ketoxime, 2-amino-6-methylbenzothiazole and meprobamate, has been determined in rabbits with experimental local tetanus. Structure-activity relationships were obtained for the phenothiazine derivatives and their anti-tetanus activity correlated with other central and peripheral properties. Both dicyclopropyl ketoxime and 2-amino-6-methyl-benzothiazole were twice as active as mephenesin. Meprobamate does not appear to be primarily a muscle relaxant of the mephenesin type.

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Selected References

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