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. 1962 Feb;18(1):161–166. doi: 10.1111/j.1476-5381.1962.tb01159.x

Actions of bretylium and guanethidine on the uptake and release of [3h]-noradrenaline

G Hertting, J Axelrod, R W Patrick
PMCID: PMC1482176  PMID: 14036196

Abstract

The effect of bretylium and guanethidine has been studied on the uptake and the spontaneous and reserpine-induced release of [3H]-noradrenaline in the rat heart and in the splenic nerve endings of the cat. Bretylium and guanethidine inhibited the uptake by the heart of circulating [3H]-noradrenaline. Bretylium blocked spontaneous and reserpine-induced release of [3H]-noradrenaline, while guanethidine caused release and partially antagonized the reserpine-induced release. Both compounds produced a transient liberation of [3H]-noradrenaline from splenic nerves, but blocked the release of the [3H]-catechol amine following stimulation of the splenic nerve.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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