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British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1962 Dec;19(3):513–526. doi: 10.1111/j.1476-5381.1962.tb01457.x

Sympathetic vasodilatation in the rabbit ear

Pamela Holton, M J Rand
PMCID: PMC1482209  PMID: 13961468

Abstract

Changes in the blood content of a 1 cm2 portion of the intact rabbit's ear were studied with transillumination and a photocell. Stimulation of the post-ganglionic sympathetic nerves produced a decrease in blood content, attributable to vasoconstriction, followed by an increased blood content, attributable to vasodilatation. The vasodilatation was enhanced by eserine and decreased by atropine. Guanethidine abolished the vasoconstriction but not the vasodilatation. After the ganglion had been decentralized by degeneration of the pre-ganglionic sympathetic nerves the vessels had an increased sensitivity to acetylcholine and the vasodilatation in response to sympathetic stimulation was enhanced. It is concluded that sympathetic stimulation results in the liberation of acetylcholine which causes vasodilatation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMBACHE N. The use and limitations of atropine for pharmacological studies on autonomic effectors. Pharmacol Rev. 1955 Dec;7(4):467–494. [PubMed] [Google Scholar]
  2. ARMIN J., GRANT R. T., THOMPSON R. H., TICKNER A. An explanation for the heightened vascular reactivity of the denervated rabbit's ear. J Physiol. 1953 Sep;121(3):603–622. doi: 10.1113/jphysiol.1953.sp004968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BOGAERT M., DE SCHAEPDRYVER A. F., DE VLEESCHHOUWER G. R. On the pharmacology of guanethidine. Arch Int Pharmacodyn Ther. 1961 Nov 1;134:224–236. [PubMed] [Google Scholar]
  4. BOURA A. L., GREEN A. F. The actions of bretylium: adrenergic neurone blocking and other effects. Br J Pharmacol Chemother. 1959 Dec;14:536–548. doi: 10.1111/j.1476-5381.1959.tb00961.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BURN J. H., RAND M. J. Noradrenaline in artery walls and its dispersal by reserpine. Br Med J. 1958 Apr 19;1(5076):903–908. doi: 10.1136/bmj.1.5076.903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BURN J. H., RAND M. J. Sympathetic postganglionic cholinergic fibres. Br J Pharmacol Chemother. 1960 Mar;15:56–66. doi: 10.1111/j.1476-5381.1960.tb01210.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. CASS R., SPRIGGS T. L. Tissue amine levels and sympathetic blockade after guanethidine and bretylium. Br J Pharmacol Chemother. 1961 Dec;17:442–450. doi: 10.1111/j.1476-5381.1961.tb01131.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CHANG V., RAND M. J. Transmission failure in sympathetic nerves produced by hemicholinium. Br J Pharmacol Chemother. 1960 Dec;15:588–600. doi: 10.1111/j.1476-5381.1960.tb00287.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DAY M. D., RAND M. J. Effect of guanethidine in revealing cholinergic sympathetic fibres. Br J Pharmacol Chemother. 1961 Oct;17:245–260. doi: 10.1111/j.1476-5381.1961.tb01285.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. EXLEY K. A. The blocking action of choline 2:6-xylyl ether bromide on adrenergic nerves. Br J Pharmacol Chemother. 1957 Sep;12(3):297–305. doi: 10.1111/j.1476-5381.1957.tb00138.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GASKELL P. Are there sympathetic vasodilator nerves to the vessels of the hands. J Physiol. 1956 Mar 28;131(3):647–656. doi: 10.1113/jphysiol.1956.sp005489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HILTON S. M., HOLTON P. Antidromic vasodilatation and blood flow in the rabbit's ear. J Physiol. 1954 Jul 28;125(1):138–147. doi: 10.1113/jphysiol.1954.sp005146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HOLTON P. Antidromic vasodilatation and inhibitors of cholinesterase. J Physiol. 1953 Apr 28;120(1-2):95–104. doi: 10.1113/jphysiol.1953.sp004875. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HOLTON P., JONES M. Some observations on changes in the blood content of the cat's pancreas during activity. J Physiol. 1960 Mar;150:479–488. doi: 10.1113/jphysiol.1960.sp006399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. HOLTON P., PERRY W. L. M. On the transmitter responsible for antidromic vasodilatation in the rabbit's ear. J Physiol. 1951 Jun;114(1-2):240–251. doi: 10.1113/jphysiol.1951.sp004615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MCCUBBIN J. W., KANEKO Y., PAGE I. H. The peripheral cardiovascular actions of guanethidine in dogs. J Pharmacol Exp Ther. 1961 Mar;131:346–354. [PubMed] [Google Scholar]

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