Abstract
Two illustrative molecular models, designed to explain the Cole-Moore K+ hyperpolarization delay, are proposed and analyzed. Both introduce a process supplementary to the usual Hodgkin-Huxley (HH) one for a K+ channel. In both cases the new process becomes involved as a consequence of the conditioning hyperpolarization of the membrane and would account for the observed delay time in the K+ current after depolarization to near ENa. The first model uses adsorption or desorption of phospholipid molecules on the surface of the assumed protein K+ channel or gate. The second model involves the translocation of the charged subunits of the channel in the hyperpolarizing electric field.
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Selected References
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