Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1988 Nov;208(5):593–596. doi: 10.1097/00000658-198811000-00008

Gastric carcinoma in young adults.

P J Matley 1, D M Dent 1, M V Madden 1, S K Price 1
PMCID: PMC1493776  PMID: 2847662

Abstract

Of 720 patients with gastric carcinoma treated over a 6-year period, 37 (5%) were 35 years of age or younger. They differed from older patients in that the usual sex ratio was altered (18 men: 19 women), and in certain histologic features. Poorly differentiated or undifferentiated lesions predominated (34 patients), and the distribution of histologic types was unusual; two thirds each were of the diffuse type (Lauren classification) or signet ring type (World Health Organization classification), and over three quarters were infiltrative (Ming classification). Intestinal metaplasia was absent in the majority of patients, and gastritis was less commonly seen than in older patients. Although most patients had long histories of disease and advanced disease, the TNM stages and the proportion undergoing curative resection (8%) were similar to those seen in older patients. Except for one who has survived 5 years, all patients in this study have died.

Full text

PDF
594

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong C. P., Dent D. M. Factors influencing prognosis in carcinoma of the stomach. Surg Gynecol Obstet. 1986 Apr;162(4):343–348. [PubMed] [Google Scholar]
  2. Armstrong C. P., Dent D. M. Gastric carcinoma. A contemporary audit. J R Coll Surg Edinb. 1985 Feb;30(1):15–20. [PubMed] [Google Scholar]
  3. BELLEGIE N. J., DAHLIN D. C. Malignant disease of the stomach in young adults. Ann Surg. 1953 Jul;138(1):7–12. doi: 10.1097/00000658-195307000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bedikian A. Y., Khankhanian N., Heilbrun L. K., Bodey G. P., Stroehlein J. R., Valdivieso M. Gastric carcinoma in young adults. South Med J. 1979 Jun;72(6):654–656. doi: 10.1097/00007611-197906000-00007. [DOI] [PubMed] [Google Scholar]
  5. Bloss R. S., Miller T. A., Copeland E. M., 3rd Carcinoma of the stomach in the young adult. Surg Gynecol Obstet. 1980 Jun;150(6):883–886. [PubMed] [Google Scholar]
  6. Correa P., Haenszel W., Cuello C., Tannenbaum S., Archer M. A model for gastric cancer epidemiology. Lancet. 1975 Jul 12;2(7924):58–60. doi: 10.1016/s0140-6736(75)90498-5. [DOI] [PubMed] [Google Scholar]
  7. Dent D. M., Vader C. G. Malignant gastro-intestinal tumours. The frequency distribution by age, sex, race and site at Groote Schuur Hospital, Cape Town, 1974-1978. S Afr Med J. 1981 Dec 5;60(23):883–885. [PubMed] [Google Scholar]
  8. Jass J. R. Role of intestinal metaplasia in the histogenesis of gastric carcinoma. J Clin Pathol. 1980 Sep;33(9):801–810. doi: 10.1136/jcp.33.9.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kruskal J. B., McCully R. B., Madden M. V., Dent D. M. Gastric carcinoma--a current clinical profile. S Afr Med J. 1986 Jul 5;70(1):7–10. [PubMed] [Google Scholar]
  10. LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. doi: 10.1111/apm.1965.64.1.31. [DOI] [PubMed] [Google Scholar]
  11. Lehtola J. Family study of gastric carcinoma; With special reference to histological types. Scand J Gastroenterol Suppl. 1978;50:3–54. [PubMed] [Google Scholar]
  12. Lundh G., Burn J. I., Kolig G., Richard C. A., Thomson J. W., van Elk P. J., Oszacki J. A co-operative international study of gastric cancer (under the auspices of the International Federation of Surgical Colleges). Ann R Coll Surg Engl. 1974 May;54(5):219–228. [PMC free article] [PubMed] [Google Scholar]
  13. Matsusaka T., Soejima K., Kodama Y., Saito T., Inokucki K. Carcinomas of the stomach in the young adults. Jpn J Surg. 1976 Dec;6(4):170–177. doi: 10.1007/BF02468988. [DOI] [PubMed] [Google Scholar]
  14. Ming S. C. Gastric carcinoma. A pathobiological classification. Cancer. 1977 Jun;39(6):2475–2485. doi: 10.1002/1097-0142(197706)39:6<2475::aid-cncr2820390626>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  15. Mori M., Sugimachi K., Ohiwa T., Okamura T., Tamura S., Inokuchi K. Early gastric carcinoma in Japanese patients under 30 years of age. Br J Surg. 1985 Apr;72(4):289–291. doi: 10.1002/bjs.1800720415. [DOI] [PubMed] [Google Scholar]
  16. Nishi K., Tokunaga A., Shimizu Y., Yoshiyuki T., Wada M., Matsukura N., Tanaka N., Onda M., Asano G. Immunohistochemical study of intracellular estradiol in human gastric cancer. Cancer. 1987 Apr 1;59(7):1328–1332. doi: 10.1002/1097-0142(19870401)59:7<1328::aid-cncr2820590716>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  17. Siurala M., Isokoski M., Varis K., Kekki M. Prevalence of gastritis in a rural population. Bioptic study of subjects selected at random. Scand J Gastroenterol. 1968;3(2):211–223. doi: 10.3109/00365526809180125. [DOI] [PubMed] [Google Scholar]
  18. TAMURA P. Y., CURTISS C. Carcinoma of the stomach in the young adult. Cancer. 1960 Mar-Apr;13:379–385. doi: 10.1002/1097-0142(196003/04)13:2<379::aid-cncr2820130223>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  19. Tso P. L., Bringaze W. L., 3rd, Dauterive A. H., Correa P., Cohn I., Jr Gastric carcinoma in the young. Cancer. 1987 Apr 1;59(7):1362–1365. doi: 10.1002/1097-0142(19870401)59:7<1362::aid-cncr2820590722>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES