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. 1989 Mar;209(3):322–327. doi: 10.1097/00000658-198903000-00012

Role of prostacyclin in the splanchnic hyperemia contributing to portal hypertension.

J V Sitzmann 1, G B Bulkley 1, M C Mitchell 1, K Campbell 1
PMCID: PMC1493952  PMID: 2493776

Abstract

To determine the possible role of prostacyclin (PGI2) as a mediator of the splanchnic hyperemia seen with portal hypertension, the portal and mesenteric hemodynamics in normal and portal hypertensive rabbits were studied before and after cyclo-oxygenase blockade. Three weeks after partial portal vein ligation, splenic pulp pressure was elevated from 4.3 +/- 0.9 to 9.8 +/- 0.8 mmHg (p less than 0.01). Mesenteric blood flow increased from 77.0 +/- 4.7 ml.min-1.100 g-1 to 99.1 +/- 5.19 ml/min-1/100 g-1. Mesenteric vascular resistance fell from 0.82 +/- 0.6 mmHg/ml-1/min-1 to 0.49 +/- 0.07 mmHg/ml-1/min-1 (p less than 0.01). These hemodynamic changes were associated with a 27.3 +/- 0.2% rise in systemic arterial levels of PGI2 (p less than 0.01) and were substantially ameliorated by cyclo-oxygenase blockade with indomethacin. The effects of indomethacin blockade were reversed by exogenous PGI2. Moreover, in normotensive rabbits, infusion of PGI2 reproduced the splanchnic hyperemia and caused a very small but significant increase in portosystemic shunting. These findings support the previously proposed concept that splanchnic hyperemia may contribute to the maintenance of chronic portal hypertension. Furthermore, they suggest that this effect may be partially mediated by splanchnic PGI2 production.

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Selected References

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  1. Adkinson N. F., Jr, Newball H. H., Findlay S., Adams K., Lichtenstein L. M. Anaphylactic release of prostaglandins from human lung in vitro. Am Rev Respir Dis. 1980 Jun;121(6):911–920. doi: 10.1164/arrd.1980.121.6.911. [DOI] [PubMed] [Google Scholar]
  2. Arroyo V., Planas R., Gaya J., Deulofeu R., Rimola A., Pérez-Ayuso R. M., Rivera F., Rodés J. Sympathetic nervous activity, renin-angiotensin system and renal excretion of prostaglandin E2 in cirrhosis. Relationship to functional renal failure and sodium and water excretion. Eur J Clin Invest. 1983 Jun;13(3):271–278. doi: 10.1111/j.1365-2362.1983.tb00100.x. [DOI] [PubMed] [Google Scholar]
  3. Benoit J. N., Zimmerman B., Premen A. J., Go V. L., Granger D. N. Role of glucagon in splanchnic hyperemia of chronic portal hypertension. Am J Physiol. 1986 Nov;251(5 Pt 1):G674–G677. doi: 10.1152/ajpgi.1986.251.5.G674. [DOI] [PubMed] [Google Scholar]
  4. Bill A. Effects of indomethacin on regional blood flow in conscious rabbits--a microsphere study. Acta Physiol Scand. 1979 Apr;105(4):437–442. doi: 10.1111/j.1748-1716.1979.tb00108.x. [DOI] [PubMed] [Google Scholar]
  5. Blanchart A., Hernando N., Fernández-Muñoz D., Hernando L., López-Novoa J. M. Lack of effect of indomethacin on systemic and splanchnic haemodynamics in portal hypertensive rats. Clin Sci (Lond) 1985 May;68(5):605–607. doi: 10.1042/cs0680605. [DOI] [PubMed] [Google Scholar]
  6. Bruix J., Bosch J., Kravetz D., Mastai R., Rodés J. Effects of prostaglandin inhibition on systemic and hepatic hemodynamics in patients with cirrhosis of the liver. Gastroenterology. 1985 Feb;88(2):430–435. doi: 10.1016/0016-5085(85)90503-7. [DOI] [PubMed] [Google Scholar]
  7. Groszmann R., Kotelanski B., Cohn J. N., Khatri I. M. Quantitation of portasystemic shunting from the splenic and mesenteric beds in alcoholic liver disease. Am J Med. 1972 Dec;53(6):715–722. doi: 10.1016/0002-9343(72)90188-x. [DOI] [PubMed] [Google Scholar]
  8. Hamilton G., Phing R. C., Hutton R. A., Dandona P., Hobbs K. E. The relationship between prostacyclin activity and pressure in the portal vein. Hepatology. 1982 Mar-Apr;2(2):236–242. doi: 10.1002/hep.1840020208. [DOI] [PubMed] [Google Scholar]
  9. Hamilton G., Rosza I., Hutton R., Chow F. P., Dandona P., Hobbs K. E. Portal vein prostacyclin activity in experimental portal hypertension in rats. Clin Sci (Lond) 1981 Mar;60(3):327–329. doi: 10.1042/cs0600327. [DOI] [PubMed] [Google Scholar]
  10. Houvenaghel A., Schrauwen E., Wechsung L. Influence of primary prostaglandins, prostacyclin and arachidonic acid on mesenteric hemodynamics in the pig. Prostaglandins Med. 1979 Feb;2(2):83–95. doi: 10.1016/0161-4630(79)90043-0. [DOI] [PubMed] [Google Scholar]
  11. Lebrec D., Blanchet L. Effect of two models of portal hypertension on splanchnic organ blood flow in the rat. Clin Sci (Lond) 1985 Jan;68(1):23–28. doi: 10.1042/cs0680023. [DOI] [PubMed] [Google Scholar]
  12. Moritz E., Kreuzer W., Schenk W. G., Jr Studies in experimental canine cirrhosis: hemodynamic alterations with emphasis on degree of spontaneous porto-systemic shunting. Ann Surg. 1973 Apr;177(4):503–506. doi: 10.1097/00000658-197304000-00020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Neutze J. M., Wyler F., Rudolph A. M. Use of radioactive microspheres to assess distribution of cardiac output in rabbits. Am J Physiol. 1968 Aug;215(2):486–495. doi: 10.1152/ajplegacy.1968.215.2.486. [DOI] [PubMed] [Google Scholar]
  14. Schulman E. S., Newball H. H., Demers L. M., Fitzpatrick F. A., Adkinson N. F., Jr Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma. Am Rev Respir Dis. 1981 Oct;124(4):402–406. doi: 10.1164/arrd.1981.124.4.402. [DOI] [PubMed] [Google Scholar]
  15. Sikuler E., Groszmann R. J. Hemodynamic studies in long- and short-term portal hypertensive rats: the relation to systemic glucagon levels. Hepatology. 1986 May-Jun;6(3):414–418. doi: 10.1002/hep.1840060315. [DOI] [PubMed] [Google Scholar]
  16. Sikuler E., Groszmann R. J. Interaction of flow and resistance in maintenance of portal hypertension in a rat model. Am J Physiol. 1986 Feb;250(2 Pt 1):G205–G212. doi: 10.1152/ajpgi.1986.250.2.G205. [DOI] [PubMed] [Google Scholar]
  17. Sikuler E., Kravetz D., Groszmann R. J. Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model. Am J Physiol. 1985 Jun;248(6 Pt 1):G618–G625. doi: 10.1152/ajpgi.1985.248.6.G618. [DOI] [PubMed] [Google Scholar]
  18. Tsunoda S., Jackson E. K., Branch R. A., Gerkens J. F. Comparison of the pulmonary, hepatic and renal extraction of PGI2 and 6-keto-PGE1. Eur J Pharmacol. 1982 Jan 22;77(2-3):147–151. doi: 10.1016/0014-2999(82)90010-3. [DOI] [PubMed] [Google Scholar]
  19. Vorobioff J., Bredfeldt J. E., Groszmann R. J. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol. 1983 Jan;244(1):G52–G57. doi: 10.1152/ajpgi.1983.244.1.G52. [DOI] [PubMed] [Google Scholar]

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