Skip to main content
Annals of Surgery logoLink to Annals of Surgery
. 1989 Apr;209(4):381–395. doi: 10.1097/00000658-198904000-00001

The surgeon's role in the management of portal hypertension.

J Terblanche 1
PMCID: PMC1493978  PMID: 2649029

Abstract

Patients with portal hypertension are referred to surgeons for several reasons. These include the management of continued active variceal bleeding; therapy after a variceal bleed to prevent further recurrent bleeds; consideration for prophylactic surgical therapy to prevent the first variceal bleed; or, rarely, an unusual cause of portal hypertension which may require some specific surgical therapy. Injection sclerotherapy is the most widely used treatment for both acute variceal bleeding and long-term management after a variceal bleed. Unfortunately it has probably been overused in the past. The need to identify the failures of sclerotherapy early and to treat them by other forms of major surgery is emphasized. The selective distal splenorenal shunt is the most widely used portosystemic shunt today, particularly in nonalcoholic cirrhotic patients. The standard portacaval shunt is still used for the management of acute variceal bleeding as well as for long-term management, particularly in alcoholic cirrhotic patients. For acute variceal bleeding the surgical alternative to sclerotherapy or shunting is simple staple-gun esophageal transection, whereas in long-term management the main alternative is an extensive devascularization and transection operation. Liver transplantation is the only therapy that cures both the portal hypertension and the underlying liver disease. All patients with cirrhosis and portal hypertension should be assessed as potential liver transplant recipients. If they are candidates for transplantation, sclerotherapy should be used to treat bleeding varices whenever possible, as this will interfere least with a subsequent liver transplant.

Full text

PDF
382

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atamkuri S. P., Bhargava D. K., Sharma M. P. Endoscopic sclerotherapy for esophageal varices: a prospective, randomised trial of absolute alcohol versus polidocanol. Indian J Gastroenterol. 1988 Apr;7(2):87–89. [PubMed] [Google Scholar]
  2. Barsoum M. S., Bolous F. I., El-Rooby A. A., Rizk-Allah M. A., Ibrahim A. S. Tamponade and injection sclerotherapy in the management of bleeding oesophageal varices. Br J Surg. 1982 Feb;69(2):76–78. doi: 10.1002/bjs.1800690206. [DOI] [PubMed] [Google Scholar]
  3. Bengmark S., Börjesson B., Hoevels J., Joelsson B., Lunderquist A., Owman T. Obliteration of esophageal varices by PTP: a follow-up of 43 patients. Ann Surg. 1979 Oct;190(4):549–554. doi: 10.1097/00000658-197910000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Berman H. L., DelGuercio L. R., Katz S. G., Hodgson W. J., Savino J. A. Minimally invasive devascularization for variceal bleeding that could not be controlled with sclerotherapy. Surgery. 1988 Sep;104(3):500–506. [PubMed] [Google Scholar]
  5. Bismuth H., Franco D., Alagille D. Portal diversion for portal hypertension in children. The first ninety patients. Ann Surg. 1980 Jul;192(1):18–24. doi: 10.1097/00000658-198007000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bornman P. C., Kahn D., Terblanche J., Worthley C., Spence R. A., Krige J. J. Rigid versus fiberoptic endoscopic injection sclerotherapy. A prospective randomized controlled trial in patients with bleeding esophageal varices. Ann Surg. 1988 Aug;208(2):175–178. doi: 10.1097/00000658-198808000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bornman P. C., Terblanche J., Kahn D., Jonker M. A., Kirsch R. E. Limitations of multiple injection sclerotherapy sessions for acute variceal bleeding. S Afr Med J. 1986 Jul 5;70(1):34–36. [PubMed] [Google Scholar]
  8. Burroughs A. K., D'Heygere F., McIntyre N. Pitfalls in studies of prophylactic therapy for variceal bleeding in cirrhotics. Hepatology. 1986 Nov-Dec;6(6):1407–1413. doi: 10.1002/hep.1840060631. [DOI] [PubMed] [Google Scholar]
  9. Cameron J. L., Herlong H. F., Sanfey H., Boitnott J., Kaufman S. L., Gott V. L., Maddrey W. C. The Budd-Chiari syndrome. Treatment by mesenteric-systemic venous shunts. Ann Surg. 1983 Sep;198(3):335–346. doi: 10.1097/00000658-198309000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cello J. P., Grendell J. H., Crass R. A., Weber T. E., Trunkey D. D. Endoscopic sclerotherapy versus portacaval shunt in patient with severe cirrhosis and acute variceal hemorrhage. Long-term follow-up. N Engl J Med. 1987 Jan 1;316(1):11–15. doi: 10.1056/NEJM198701013160103. [DOI] [PubMed] [Google Scholar]
  11. Conn H. O., Lindenmuth W. W., May C. J., Ramsby G. R. Prophylactic portacaval anastomosis. Medicine (Baltimore) 1972 Jan;51(1):27–40. doi: 10.1097/00005792-197201000-00002. [DOI] [PubMed] [Google Scholar]
  12. Conn H. O., Resnick R. H., Grace N. D., Atterbury C. E., Horst D., Groszmann R. J., Gazmuri P., Gusberg R. J., Thayer B., Berk D. Distal splenorenal shunt vs. portal-systemic shunt: current status of a controlled trial. Hepatology. 1981 Mar-Apr;1(2):151–160. doi: 10.1002/hep.1840010211. [DOI] [PubMed] [Google Scholar]
  13. Drapanas T. Interposition mesocaval shunt for treatment of portal hypertension. Ann Surg. 1972 Oct;176(4):435–448. doi: 10.1097/00000658-197210000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Fischer J. E., Bower R. H., Atamian S., Welling R. Comparison of distal and proximal splenorenal shunts: a randomized prospective trial. Ann Surg. 1981 Oct;194(4):531–544. doi: 10.1097/00000658-198110000-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Fleig W. E., Stange E. F., Hunecke R., Schönborn W., Hurler U., Rainer K., Gaus W., Ditschuneit H. Prevention of recurrent bleeding in cirrhotics with recent variceal hemorrhage: prospective, randomized comparison of propranolol and sclerotherapy. Hepatology. 1987 Mar-Apr;7(2):355–361. doi: 10.1002/hep.1840070224. [DOI] [PubMed] [Google Scholar]
  16. Gouge T. H., Ranson J. H. Esophageal transection and paraesophagogastric devascularization for bleeding esophageal varices. Am J Surg. 1986 Jan;151(1):47–54. doi: 10.1016/0002-9610(86)90010-3. [DOI] [PubMed] [Google Scholar]
  17. Groszmann R. J., Kravetz D., Bosch J., Glickman M., Bruix J., Bredfeldt J., Conn H. O., Rodes J., Storer E. H. Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension. Hepatology. 1982 Nov-Dec;2(6):757–762. doi: 10.1002/hep.1840020602. [DOI] [PubMed] [Google Scholar]
  18. Harley H. A., Morgan T., Redeker A. G., Reynolds T. B., Villamil F., Weiner J. M., Yellin A. Results of a randomized trial of end-to-side portacaval shunt and distal splenorenal shunt in alcoholic liver disease and variceal bleeding. Gastroenterology. 1986 Oct;91(4):802–809. doi: 10.1016/0016-5085(86)90679-7. [DOI] [PubMed] [Google Scholar]
  19. Hassab M. A. Gastroesophageal decongestion and splenectomy in the treatment of esophageal varices in bilharzial cirrhosis: further studies with a report on 355 operations. Surgery. 1967 Feb;61(2):169–176. [PubMed] [Google Scholar]
  20. Henderson J. M., El Khishen M. A., Millikan W. J., Jr, Sones P. J., Warren W. D. Management of stenosis of distal splenorenal shunt by balloon dilation. Surg Gynecol Obstet. 1983 Jul;157(1):43–48. [PubMed] [Google Scholar]
  21. Henderson J. M., Millikan W. J., Jr, Wright-Bacon L., Kutner M. H., Warren W. D. Hemodynamic differences between alcoholic and nonalcoholic cirrhotics following distal splenorenal shunt--effect on survival? Ann Surg. 1983 Sep;198(3):325–334. doi: 10.1097/00000658-198309000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hoffmann J. Stapler transection of the oesophagus for bleeding oesophageal varices. Scand J Gastroenterol. 1983 Sep;18(6):707–711. doi: 10.3109/00365528309182084. [DOI] [PubMed] [Google Scholar]
  23. Hosking S. W., Doss W., el-Zeiny H., Robinson P., Barsoum M. S., Johnson A. G. Pharmacological constriction of the lower oesophageal sphincter: a simple method of arresting variceal haemorrhage. Gut. 1988 Aug;29(8):1098–1102. doi: 10.1136/gut.29.8.1098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Hosking S. W., Johnson A. G. What happens to esophageal varices after transection and devascularization? Surgery. 1987 May;101(5):531–534. [PubMed] [Google Scholar]
  25. Howard E. R., Stringer M. D., Mowat A. P. Assessment of injection sclerotherapy in the management of 152 children with oesophageal varices. Br J Surg. 1988 May;75(5):404–408. doi: 10.1002/bjs.1800750504. [DOI] [PubMed] [Google Scholar]
  26. Inokuchi K., Beppu K., Koyanagi N., Nagamine K., Hashizume M., Sugimachi K. Exclusion of nonisolated splenic vein in distal splenorenal shunt for prevention of portal malcirculation. Ann Surg. 1984 Dec;200(6):711–717. doi: 10.1097/00000658-198412000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Inokuchi K., Kobayashi M., Kusaba A., Ogawa Y., Saku M., Shiizaki T. New selective decompression of esophageal varices. By a left gastric venous-caval shunt. Arch Surg. 1970 Feb;100(2):157–162. doi: 10.1001/archsurg.1970.01340200045011. [DOI] [PubMed] [Google Scholar]
  28. Inokuchi K. Present status of surgical treatment of esophageal varices in Japan: a nationwide survey of 3,588 patients. World J Surg. 1985 Feb;9(1):171–180. doi: 10.1007/BF01656275. [DOI] [PubMed] [Google Scholar]
  29. Inokuchi K. Prophylactic portal nondecompression surgery in patients with esophageal varices. An interim report. Ann Surg. 1984 Jul;200(1):61–65. doi: 10.1097/00000658-198407000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Iwatsuki S., Starzl T. E., Todo S., Gordon R. D., Esquivel C. O., Tzakis A. G., Makowka L., Marsh J. W., Koneru B., Stieber A. Experience in 1,000 liver transplants under cyclosporine-steroid therapy: a survival report. Transplant Proc. 1988 Feb;20(1 Suppl 1):498–504. [PMC free article] [PubMed] [Google Scholar]
  31. Iwatsuki S., Starzl T. E., Todo S., Gordon R. D., Tzakis A. G., Marsh J. W., Makowka L., Koneru B., Stieber A., Klintmalm G. Liver transplantation in the treatment of bleeding esophageal varices. Surgery. 1988 Oct;104(4):697–705. [PMC free article] [PubMed] [Google Scholar]
  32. Jackson F. C., Perrin E. B., Felix W. R., Smith A. G. A clinical investigation of the portacaval shunt. V. Survival analysis of the therapeutic operation. Ann Surg. 1971 Oct;174(4):672–701. doi: 10.1097/00000658-197110000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Jackson F. C., Perrin E. B., Smith A. G., Dagradi A. E., Nadal H. M. A clinical investigation of the portacaval shunt. II. Survival analysis of the prophylactic operation. Am J Surg. 1968 Jan;115(1):22–42. doi: 10.1016/0002-9610(68)90127-x. [DOI] [PubMed] [Google Scholar]
  34. Kahn D., Terblanche J., Kitano S., Bornman P. Injection sclerotherapy in adult patients with extrahepatic portal venous obstruction. Br J Surg. 1987 Jul;74(7):600–602. doi: 10.1002/bjs.1800740720. [DOI] [PubMed] [Google Scholar]
  35. Keagy B. A., Schwartz J. A., Johnson G., Jr Should ablative operations be used for bleeding esophageal varices? Ann Surg. 1986 May;203(5):463–469. doi: 10.1097/00000658-198605000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Kitano S., Iso Y., Koyanagi N., Higashi H., Sugimachi K. Ethanolamine oleate is superior to polidocanol (aethoxysklerol) for endoscopic injection sclerotherapy of esophageal varices: a prospective randomized trial. Hepatogastroenterology. 1987 Feb;34(1):19–23. [PubMed] [Google Scholar]
  37. Kitano S., Iso Y., Yamaga H., Hashizume M., Higashi H., Sugimachi K. Trial of sclerosing agents in patients with oesophageal varices. Br J Surg. 1988 Aug;75(8):751–753. doi: 10.1002/bjs.1800750810. [DOI] [PubMed] [Google Scholar]
  38. Kitano S., Terblanche J., Kahn D., Bornman P. C. Venous anatomy of the lower oesophagus in portal hypertension: practical implications. Br J Surg. 1986 Jul;73(7):525–531. doi: 10.1002/bjs.1800730704. [DOI] [PubMed] [Google Scholar]
  39. Koch H., Henning H., Grimm H., Soehendra N. Prophylactic sclerosing of esophageal varices--results of a prospective controlled study. Endoscopy. 1986 Mar;18(2):40–43. doi: 10.1055/s-2007-1018322. [DOI] [PubMed] [Google Scholar]
  40. Korula J., Balart L. A., Radvan G., Zweiban B. E., Larson A. W., Kao H. W., Yamada S. A prospective, randomized controlled trial of chronic esophageal variceal sclerotherapy. Hepatology. 1985 Jul-Aug;5(4):584–589. doi: 10.1002/hep.1840050410. [DOI] [PubMed] [Google Scholar]
  41. Langer B., Taylor B. R., Mackenzie D. R., Gilas T., Stone R. M., Blendis L. Further report of a prospective randomized trial comparing distal splenorenal shunt with end-to-side portacaval shunt. An analysis of encephalopathy, survival, and quality of life. Gastroenterology. 1985 Feb;88(2):424–429. doi: 10.1016/0016-5085(85)90502-5. [DOI] [PubMed] [Google Scholar]
  42. Larson A. W., Cohen H., Zweiban B., Chapman D., Gourdji M., Korula J., Weiner J. Acute esophageal variceal sclerotherapy. Results of a prospective randomized controlled trial. JAMA. 1986 Jan 24;255(4):497–500. [PubMed] [Google Scholar]
  43. Lilly J. R. Endoscopic sclerosis of esophageal varices in children. Surg Gynecol Obstet. 1981 Apr;152(4):513–514. [PubMed] [Google Scholar]
  44. Madsen M. S., Petersen T. H., Sommer H. Segmental portal hypertension. Ann Surg. 1986 Jul;204(1):72–77. doi: 10.1097/00000658-198607000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Maillard J. N., Flamant Y. M., Hay J. M., Chandler J. G. Selectivity of the distal splenorenal shunt. Surgery. 1979 Nov;86(5):663–671. [PubMed] [Google Scholar]
  46. Marbet U. A., Straumann A., Gyr K. E., Beglinger C., Schaub N., Bögtlin J., Loosli J., Kiowski W., Ritz R., Stalder G. A. Reduction in early recurrence of variceal bleeding by propranolol. Scand J Gastroenterol. 1988 Apr;23(3):369–374. doi: 10.3109/00365528809093881. [DOI] [PubMed] [Google Scholar]
  47. Matory W. E., Jr, Sedgwick C. E., Rossi R. L. Nonshunting procedures in management of bleeding esophageal varices. Surg Clin North Am. 1980 Apr;60(2):281–295. doi: 10.1016/s0039-6109(16)42081-5. [DOI] [PubMed] [Google Scholar]
  48. McCormack T. T., Sims J., Eyre-Brook I., Kennedy H., Goepel J., Johnson A. G., Triger D. R. Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? Gut. 1985 Nov;26(11):1226–1232. doi: 10.1136/gut.26.11.1226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Millikan W. J., Jr, Warren W. D., Henderson J. M., Smith R. B., 3rd, Salam A. A., Galambos J. T., Kutner M. H., Keen J. H. The Emory prospective randomized trial: selective versus nonselective shunt to control variceal bleeding. Ten year follow-up. Ann Surg. 1985 Jun;201(6):712–722. doi: 10.1097/00000658-198506000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Novis B. H., Duys P., Barbezat G. O., Clain J., Bank S., Terblanche J. Fibreoptic endoscopy and the use of the Sengstaken tube in acute gastrointestinal haemorrhage in patients with portal hypertension and varices. Gut. 1976 Apr;17(4):258–263. doi: 10.1136/gut.17.4.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Orloff M. J., Bell R. H., Jr, Hyde P. V., Skivolocki W. P. Long-term results of emergency portacaval shunt for bleeding esophageal varices in unselected patients with alcoholic cirrhosis. Ann Surg. 1980 Sep;192(3):325–340. doi: 10.1097/00000658-198009000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Osborne D. R., Hobbs K. E. The acute treatment of haemorrhage from oesophageal varices: a comparison of oesophageal transection and staple gun anastomosis with mesocaval shunt. Br J Surg. 1981 Oct;68(10):734–737. doi: 10.1002/bjs.1800681019. [DOI] [PubMed] [Google Scholar]
  53. PETERS R. M., WOMACK N. A. Surgery of vascular distortions in cirrhosis of the liver. Ann Surg. 1961 Sep;154:432–445. doi: 10.1097/00000658-196109000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Panés J., Terés J., Bosch J., Rodés J. Efficacy of balloon tamponade in treatment of bleeding gastric and esophageal varices. Results in 151 consecutive episodes. Dig Dis Sci. 1988 Apr;33(4):454–459. doi: 10.1007/BF01536031. [DOI] [PubMed] [Google Scholar]
  55. Papazian A., Braillon A., Dupas J. L., Sevenet F., Capron J. P. Portal hypertensive gastric mucosa: an endoscopic study. Gut. 1986 Oct;27(10):1199–1203. doi: 10.1136/gut.27.10.1199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Paquet K. J. Endoscopic paravariceal injection sclerotherapy of the esophagus--indications, technique, complications: results of a period of 14 years. Gastrointest Endosc. 1983 Nov;29(4):310–315. doi: 10.1016/s0016-5107(83)72642-8. [DOI] [PubMed] [Google Scholar]
  57. Paquet K. J., Feussner H. Endoscopic sclerosis and esophageal balloon tamponade in acute hemorrhage from esophagogastric varices: a prospective controlled randomized trial. Hepatology. 1985 Jul-Aug;5(4):580–583. doi: 10.1002/hep.1840050409. [DOI] [PubMed] [Google Scholar]
  58. Paquet K. J., Kalk J. F., Koussouris P. Immediate endoscopic sclerosis of bleeding esophageal varices. A prospective evaluation over five years. Surg Endosc. 1988;2(1):18–23. doi: 10.1007/BF00591393. [DOI] [PubMed] [Google Scholar]
  59. Paquet K. J. Prophylactic endoscopic sclerosing treatment of the esophageal wall in varices -- a prospective controlled randomized trial. Endoscopy. 1982 Jan;14(1):4–5. doi: 10.1055/s-2007-1021560. [DOI] [PubMed] [Google Scholar]
  60. Poynard T., Lebrec D., Hillon P., Sayegh R., Bernuau J., Naveau S., Chaput J. C., Klepping C., Rueff B., Benhamou J. P. Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a prospective study of factors associated with rebleeding. Hepatology. 1987 May-Jun;7(3):447–451. doi: 10.1002/hep.1840070306. [DOI] [PubMed] [Google Scholar]
  61. Reichle F. A., Fahmy W. F., Golsorkhi M. Prospective comparative clinical trial with distal splenorenal and mesocaval shunts. Am J Surg. 1979 Jan;137(1):13–21. doi: 10.1016/0002-9610(79)90004-7. [DOI] [PubMed] [Google Scholar]
  62. Resnick R. H., Chalmers T. C., Ishihara A. M., Garceau A. J., Callow A. D., Schimmel E. M., O'Hara E. T. A controlled study of the prophylactic portacaval shunt. A final report. Ann Intern Med. 1969 Apr;70(4):675–688. doi: 10.7326/0003-4819-70-4-675. [DOI] [PubMed] [Google Scholar]
  63. Resnick R. H., Iber F. L., Ishihara A. M., Chalmers T. C., Zimmerman H. A controlled study of the therapeutic portacaval shunt. Gastroenterology. 1974 Nov;67(5):843–857. [PubMed] [Google Scholar]
  64. Reynolds T. B., Donovan A. J., Mikkelsen W. P., Redeker A. G., Turrill F. L., Weiner J. M. Results of a 12-year randomized trial of portacaval shunt in patients with alcoholic liver disease and bleeding varices. Gastroenterology. 1981 May;80(5 Pt 1):1005–1011. [PubMed] [Google Scholar]
  65. Rikkers L. F., Burnett D. A., Volentine G. D., Buchi K. N., Cormier R. A. Shunt surgery versus endoscopic sclerotherapy for long-term treatment of variceal bleeding. Early results of a randomized trial. Ann Surg. 1987 Sep;206(3):261–271. doi: 10.1097/00000658-198709000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Rueff B., Prandi D., Degos F., Sicot J., Degos J. D., Sicot C., Maillard J. N., Fauvert R., Benhamou J. P. A controlled study of therapeutic portacaval shunt in alcoholic cirrhosis. Lancet. 1976 Mar 27;1(7961):655–659. doi: 10.1016/s0140-6736(76)92775-6. [DOI] [PubMed] [Google Scholar]
  67. Santangelo W. C., Dueno M. I., Estes B. L., Krejs G. J. Prophylactic sclerotherapy of large esophageal varices. N Engl J Med. 1988 Mar 31;318(13):814–818. doi: 10.1056/NEJM198803313181304. [DOI] [PubMed] [Google Scholar]
  68. Sarfeh I. J., Rypins E. B., Mason G. R. A systematic appraisal of portacaval H-graft diameters. Clinical and hemodynamic perspectives. Ann Surg. 1986 Oct;204(4):356–363. doi: 10.1097/00000658-198610000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Sarfeh I. J., Tabak C., Eugene J., Juler G. L. Clinical significance of erosive gastritis in patients with alcoholic liver disease and upper gastrointestinal hemorrhage. Ann Surg. 1981 Aug;194(2):149–151. doi: 10.1097/00000658-198108000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Sarin S. K., Nanda R., Sachdev G., Chari S., Anand B. S., Broor S. L. Intravariceal versus paravariceal sclerotherapy: a prospective, controlled, randomised trial. Gut. 1987 Jun;28(6):657–662. doi: 10.1136/gut.28.6.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Sarin S. K., Sachdev G., Nanda R., Batra S. K., Anand B. S. Comparison of the two time schedules for endoscopic sclerotherapy: a prospective randomised controlled study. Gut. 1986 Jun;27(6):710–713. doi: 10.1136/gut.27.6.710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Sarin S. K., Sachdev G., Nanda R. Follow-up of patients after variceal eradication. A comparison of patients with cirrhosis, noncirrhotic portal fibrosis, and extrahepatic obstruction. Ann Surg. 1986 Jul;204(1):78–82. doi: 10.1097/00000658-198607000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Sarr M. G., Herlong H. F., Cameron J. L. Long-term patency of the mesocaval C shunt. Am J Surg. 1986 Jan;151(1):98–103. doi: 10.1016/0002-9610(86)90018-8. [DOI] [PubMed] [Google Scholar]
  74. Sauerbruch T., Wotzka R., Köpcke W., Härlin M., Heldwein W., Bayerdörffer E., Sander R., Ansari H., Starz I., Paumgartner G. Prophylactic sclerotherapy before the first episode of variceal hemorrhage in patients with cirrhosis. N Engl J Med. 1988 Jul 7;319(1):8–15. doi: 10.1056/NEJM198807073190102. [DOI] [PubMed] [Google Scholar]
  75. Schubert T., Smith O., Kirkpatrick S., Chen S., Molos M. Improved survival in variceal hemorrhage with emergent sclerotherapy. Am J Gastroenterol. 1987 Nov;82(11):1134–1137. [PubMed] [Google Scholar]
  76. Spence R. A., Johnston G. W. Results in 100 consecutive patients with stapled esophageal transection for varices. Surg Gynecol Obstet. 1985 Apr;160(4):323–329. [PubMed] [Google Scholar]
  77. Sugiura M., Futagawa S. Results of six hundred thirty-six esophageal transections with paraesophagogastric devascularization in the treatment of esophageal varices. J Vasc Surg. 1984 Mar;1(2):254–260. [PubMed] [Google Scholar]
  78. Söderlund C., Ihre T. Endoscopic sclerotherapy v. conservative management of bleeding oesophageal varices. A 5-year prospective controlled trial of emergency and long-term treatment. Acta Chir Scand. 1985;151(5):449–456. [PubMed] [Google Scholar]
  79. TANNER N. C. The late results of porto-azygos disconnexion in the treatment of bleeding from oesophageal varices. Ann R Coll Surg Engl. 1961 Mar;28:153–174. [PMC free article] [PubMed] [Google Scholar]
  80. Terblanche J., Bornman P. C., Kahn D., Jonker M. A., Campbell J. A., Wright J., Kirsch R. Failure of repeated injection sclerotherapy to improve long-term survival after oesophageal variceal bleeding. A five-year prospective controlled clinical trial. Lancet. 1983 Dec 10;2(8363):1328–1332. doi: 10.1016/s0140-6736(83)91090-5. [DOI] [PubMed] [Google Scholar]
  81. Terblanche J. The long-term management of patients after an oesophageal variceal bleed: the role of sclerotherapy. Br J Surg. 1985 Feb;72(2):88–90. doi: 10.1002/bjs.1800720204. [DOI] [PubMed] [Google Scholar]
  82. Terblanche J., Yakoob H. I., Bornman P. C., Stiegmann G. V., Bane R., Jonker M., Wright J., Kirsch R. Acute bleeding varices: a five-year prospective evaluation of tamponade and sclerotherapy. Ann Surg. 1981 Oct;194(4):521–530. doi: 10.1097/00000658-198110000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Terés J., Baroni R., Bordas J. M., Visa J., Pera C., Rodés J. Randomized trial of portacaval shunt, stapling transection and endoscopic sclerotherapy in uncontrolled variceal bleeding. J Hepatol. 1987 Apr;4(2):159–167. doi: 10.1016/s0168-8278(87)80075-2. [DOI] [PubMed] [Google Scholar]
  84. Terés J., Bordas J. M., Bravo D., Visa J., Grande L., Garcia-Valdecasas J. C., Pera C., Rodés J. Sclerotherapy vs. distal splenorenal shunt in the elective treatment of variceal hemorrhage: a randomized controlled trial. Hepatology. 1987 May-Jun;7(3):430–436. doi: 10.1002/hep.1840070303. [DOI] [PubMed] [Google Scholar]
  85. Van Stiegmann G., Goff J. S. Endoscopic esophageal varix ligation: preliminary clinical experience. Gastrointest Endosc. 1988 Mar-Apr;34(2):113–117. doi: 10.1016/s0016-5107(88)71274-2. [DOI] [PubMed] [Google Scholar]
  86. Villeneuve J. P., Pomier-Layrargues G., Duguay L., Lapointe R., Tanguay S., Marleau D., Willems B., Huet P. M., Infante-Rivard C., Lavoie P. Emergency portacaval shunt for variceal hemorrhage. A prospective study. Ann Surg. 1987 Jul;206(1):48–52. doi: 10.1097/00000658-198707000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Vons C., Smadja C., Bourstyn E., Szekely A. M., Bonnet P., Franco D. Results of portal systemic shunts in Budd-Chiari syndrome. Ann Surg. 1986 Apr;203(4):366–370. doi: 10.1097/00000658-198604000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Warren W. D., Henderson J. M., Millikan W. J., Galambos J. T., Brooks W. S., Riepe S. P., Salam A. A., Kutner M. H. Distal splenorenal shunt versus endoscopic sclerotherapy for long-term management of variceal bleeding. Preliminary report of a prospective, randomized trial. Ann Surg. 1986 May;203(5):454–462. doi: 10.1097/00000658-198605000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Warren W. D., Millikan W. J., Jr, Henderson J. M., Abu-Elmagd K. M., Galloway J. R., Shires G. T., 3rd, Richards W. O., Salam A. A., Kutner M. H. Splenopancreatic disconnection. Improved selectivity of distal splenorenal shunt. Ann Surg. 1986 Oct;204(4):346–355. doi: 10.1097/00000658-198610000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Warren W. D., Zeppa R., Fomon J. J. Selective trans-splenic decompression of gastroesophageal varices by distal splenorenal shunt. Ann Surg. 1967 Sep;166(3):437–455. doi: 10.1097/00000658-196709000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Westaby D., Macdougall B. R., Williams R. Improved survival following injection sclerotherapy for esophageal varices: final analysis of a controlled trial. Hepatology. 1985 Sep-Oct;5(5):827–830. doi: 10.1002/hep.1840050520. [DOI] [PubMed] [Google Scholar]
  92. Westaby D., Melia W. M., Macdougall B. R., Hegarty J. E., Williams R. Injection sclerotherapy for oesophageal varices: a prospective randomised trial of different treatment schedules. Gut. 1984 Feb;25(2):129–132. doi: 10.1136/gut.25.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Whipple A. O. The Problem of Portal Hypertension in Relation to the Hepatosplenopathies. Ann Surg. 1945 Oct;122(4):449–475. doi: 10.1097/00000658-194510000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Witzel L., Wolbergs E., Merki H. Prophylactic endoscopic sclerotherapy of oesophageal varices. A prospective controlled study. Lancet. 1985 Apr 6;1(8432):773–775. doi: 10.1016/s0140-6736(85)91444-8. [DOI] [PubMed] [Google Scholar]
  95. da Silva L. C., Strauss E., Gayotto L. C., Mies S., Macedo A. L., da Silva A. T., Silva E. F., Lacet C. M., Antonelli R. H., Fermanian J. A randomized trial for the study of the elective surgical treatment of portal hypertension in mansonic schistosomiasis. Ann Surg. 1986 Aug;204(2):148–153. doi: 10.1097/00000658-198608000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES