Abstract
Toxicity tests with lyophilized M. aeruginosa NRC-1 cells have been conducted using mice, guinea pigs, rabbits, chickens, ducks, two calves and one lamb as the test animals.
The symptoms and pathological changes are described. On an equivalent weight basis it required three to five times the oral dosage to kill the large animals and birds as it did to kill the laboratory animals. The symptoms were less pronounced and the survival times were longer in the more resistant animals. Enlargement and congestion of the liver with necrosis of the hepatic cells were constant and pathognomonic. These findings are in general agreement with the observations of other workers who have examined the toxicity of naturally occurring Microcystis waterblooms.
The toxicities and structures of microcystin and of six other biologically active cyclic polypeptides are summarized. The pathological effects produced by microcystin in laboratory and domestic animals resemble those produced in man but differ from those produced in animals by the toxic peptides of Amanita phalloides.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ashworth C. T., Mason M. F. Observations on the Pathological Changes Produced by a Toxic Substance Present in Blue-Green Algae (Microcystis aeruginosa). Am J Pathol. 1946 Mar;22(2):369–383. [PMC free article] [PubMed] [Google Scholar]
- BISHOP C. T., ANET E. F., GORHAM P. R. Isolation and identification of the fast-death factor in Microcystis aeruginosa NRC-1. Can J Biochem Physiol. 1959 Mar;37(3):453–471. [PubMed] [Google Scholar]
- DILLENBERG H. O., DEHNEL M. K. Toxic waterbloom in Saskatchewan, 1959. Can Med Assoc J. 1960 Nov 26;83:1151–1154. [PMC free article] [PubMed] [Google Scholar]
- ERLANGER B. F., GOODE L. Antibacterial activity of acyclic decapeptide analogs of gramicidin S. Science. 1960 Mar 4;131(3401):669–670. doi: 10.1126/science.131.3401.669. [DOI] [PubMed] [Google Scholar]
- GORHAM P. R. Laboratory studies on the toxins produced by waterblooms of blue-green algae. Am J Public Health Nations Health. 1962 Dec;52:2100–2105. doi: 10.2105/ajph.52.12.2100. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gorham P. R. Toxic Waterblooms of Blue-Green Algae. Can Vet J. 1960 Jun;1(6):235–245. [PMC free article] [PubMed] [Google Scholar]
- HUGHES E. O., GORHAM P. R., ZEHNDER A. Toxicity of a unialgal culture of Microcystis aeruginosa. Can J Microbiol. 1958 Jun;4(3):225–236. doi: 10.1139/m58-024. [DOI] [PubMed] [Google Scholar]
- JAMES A. T., SYNGE R. L. M. Non-peptide linkages in gramicidin. Biochem J. 1951 Nov;50(1):109–118. doi: 10.1042/bj0500109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macdonald D. W. Algal Poisoning in Beef Cattle. Can Vet J. 1960 Mar;1(3):108–110. [PMC free article] [PubMed] [Google Scholar]
- O'donoghue J. G., Wilton G. S. Algal Poisoning in Alberta. Can J Comp Med Vet Sci. 1951 Aug;15(8):193–198. [PMC free article] [PubMed] [Google Scholar]
- RASZEJA S. [Histological studies on the liver in mushroom poisoning (Amanita phalloides)]. Dtsch Z Gesamte Gerichtl Med. 1960;50:417–422. [PubMed] [Google Scholar]
- STEWART A. G., BARNUM D. A., HENDERSON J. A. Algal poisoning in Ontario. Can J Comp Med Vet Sci. 1950 Jun;14(6):197–202. [PMC free article] [PubMed] [Google Scholar]
- Senior V. E. Algal Poisoning in Saskatchewan. Can J Comp Med Vet Sci. 1960 Jan;24(1):26–31. [PMC free article] [PubMed] [Google Scholar]
- ZEHNDER A., GORHAM P. R. Factors influencing the growth of Microcystis aeruginosa Kutz, emend, Elenkin. Can J Microbiol. 1960 Dec;6:645–660. doi: 10.1139/m60-077. [DOI] [PubMed] [Google Scholar]