Abstract
The protective effect of orally administered immune (E. COLI 08:K.:H21) serum was demonstrated in experimentally infected gnotobiotic pigs. The temporary protective effect of the immune serum and the correlation of protection with IN VITRO antibody determinations were discussed. The results indicated that the protective action of the immune serum is apparently not dependent upon the complement-antibody bactericidal system. It was suggested that the most plausible mechanism of action of the immune serum was the inactivation of endotoxin in the lumen of the intestine.
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Selected References
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- BARKSDALE W. L., GHODA A. Agglutinating antibodies in serum and feces. J Immunol. 1951 Mar;66(3):395–401. [PubMed] [Google Scholar]
- COOPER M. L., KELLER H. M., WALTERS E. W. Escherichia coli associated with infantile diarrhea. Ann N Y Acad Sci. 1956 Aug 10;66(1):78–89. doi: 10.1111/j.1749-6632.1956.tb40105.x. [DOI] [PubMed] [Google Scholar]
- Chopra S. L., Blackwood A. C., Dale D. G. Enteritis of Early Weaned Pigs : II. Pathogenesis. Can J Comp Med Vet Sci. 1964 Nov;28(11):272–278. [PMC free article] [PubMed] [Google Scholar]
- Harrison P. E., Banvard J. Coproantibody Excretion During Enteric Infections. Science. 1947 Aug 29;106(2748):188–189. doi: 10.1126/science.106.2748.188. [DOI] [PubMed] [Google Scholar]
- JONES J. E., SMITH H. W. THE EFFECT OF INTRAVENOUS INJECTION OF EXTRACTS OF ESCHERICHIA COLI IN PIGS AND MICE. J Pathol Bacteriol. 1964 Jan;87:113–122. doi: 10.1002/path.1700870116. [DOI] [PubMed] [Google Scholar]
- LEMCKE R. M., HURST A. Antibody content of colostrum and piglet serum following vaccination of the sow. J Comp Pathol. 1961 Jul;71:268–278. doi: 10.1016/s0368-1742(61)80033-7. [DOI] [PubMed] [Google Scholar]
- MEYER R. C., BOHL E. H., KOHLER E. M. PROCUREMENT AND MAINTENANCE OF GERM-FREE SEINE FOR MICROBIOLOGICAL INVESTIGATIONS. Appl Microbiol. 1964 Jul;12:295–300. doi: 10.1128/am.12.4.295-300.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MUSCHEL L. H., JACKSON J. E. A HUMORAL ANTIBODY ASSOCIATED WITH ENDOTOXIN RESISTANCE. Proc Soc Exp Biol Med. 1964 May;116:182–186. doi: 10.3181/00379727-116-29196. [DOI] [PubMed] [Google Scholar]
- Rice C. E., L'ecuyer C. Complement Titres of Naturally and Artificially Raised Piglets: I. In piglets of different birth weights. Can J Comp Med Vet Sci. 1963 Jul;27(7):157–161. [PMC free article] [PubMed] [Google Scholar]
- SMITH H. W., JONES J. E. OBSERVATIONS ON THE ALIMENTARY TRACT AND ITS BACTERIAL FLORA IN HEALTHY AND DISEASED PIGS. J Pathol Bacteriol. 1963 Oct;86:387–412. [PubMed] [Google Scholar]
- SPEER V. C., BROWN H., QUINN L., CATRON D. V. The cessation of antibody absorption in the young pig. J Immunol. 1959 Dec;83:632–634. [PubMed] [Google Scholar]
- STERZL J., KOSTKA J., LANC A. Development of bactericidal properties against gram-negative organisms in the serum of young animals. Folia Microbiol (Praha) 1962 May;7:162–174. doi: 10.1007/BF02928237. [DOI] [PubMed] [Google Scholar]
- WHEELER W. E. Spread and control of Escherichia coli diarrheal disease. Ann N Y Acad Sci. 1956 Aug 10;66(1):112–117. doi: 10.1111/j.1749-6632.1956.tb40109.x. [DOI] [PubMed] [Google Scholar]