Abstract
The Cyprus strain of bluetongue virus was successfully transmitted through six passages and the Station strain through one passage in calves. Although the animals developed no visible evidence of infection, viremia as shown by both passage and fluorescent antibody examination of infected foetal bovine kidney culture, and by serological conversion was nevertheless demonstrated. No enhancement of virulence for calves or sheep was shown following bovine passage. A ewe inoculated in late pregnancy with blood drawn from a calf 59 days after its infection, gave birth to a lamb from whose blood the virus was isolated. Significant complement-fixation titres persisted for at least 200 days.
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Selected References
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- Boulanger P., Ruckerbauer G. M., Bannister G. L., Gray D. P., Girard A. Studies on bluetongue. 3. Comparison of two complement-fixation methods. Can J Comp Med Vet Sci. 1967 Jul;31(7):166–170. [PMC free article] [PubMed] [Google Scholar]
- CORDY D. R., SHULTZ G. Congenital subcortical encephalopathies in lambs. J Neuropathol Exp Neurol. 1961 Oct;20:554–562. doi: 10.1097/00005072-196120040-00006. [DOI] [PubMed] [Google Scholar]
- Girard A., Ruckerbauer G. M., Gray D. P., Bannister G. L., Boulanger P. Studies on bluetongue. IV. Studies of three strains in primary bovine foetal kidney cell cultures. Can J Comp Med Vet Sci. 1967 Jul;31(7):171–174. [PMC free article] [PubMed] [Google Scholar]
- Gray D. P., Bannister G. L. Studies on Bluetongue - I. Infectivity of the Virus in the Sheep Ked, Melophagus ovinus (L.). Can J Comp Med Vet Sci. 1961 Sep;25(9):230–232. [PMC free article] [PubMed] [Google Scholar]
- Howell P. G. Some aspects of the epizootiology of bluetongue. Bull Off Int Epizoot. 1966 May;66(1):341–352. [PubMed] [Google Scholar]
- Owen N. C., Du Toit R. M., Howell P. G. Bluetongue in cattle: typing of viruses isolated from cattle exposed to natural infections. Onderstepoort J Vet Res. 1965 Jun;32(1):3–6. [PubMed] [Google Scholar]
- ROBERTSON A., APPEL M., BANNISTER G. L., RUCKERBAUER G. M., BOULANGER P. STUDIES ON BLUETONGUE II. COMPLEMENT-FIXING ACTIVITY OF OVINE AND BOVINE SERA. Can J Comp Med Vet Sci. 1965 May;29:113–117. [PMC free article] [PubMed] [Google Scholar]
- Richards W. P., Cordy D. R. Bluetongue virus infection: pathologic responses of nervous systems in sheep and mice. Science. 1967 Apr 28;156(3774):530–531. doi: 10.1126/science.156.3774.530. [DOI] [PubMed] [Google Scholar]
- Ruckerbauer G. M., Gray D. P., Girard A., Bannister G. L., Boulanger P. Studies on bluetongue. V. Detection of the virus in infected materials by immunofluorescence. Can J Comp Med Vet Sci. 1967 Jul;31(7):175–181. [PMC free article] [PubMed] [Google Scholar]
- SCHULTZ G., DELAY P. D. Losses in newborn lambs associated with bluetongue vaccination of pregnancy ewes. J Am Vet Med Assoc. 1955 Sep;127(942):224–226. [PubMed] [Google Scholar]
- YOUNG S., CORDY D. R. AN OVINE FETAL ENCEPHALOPATHY CAUSED BY BLUETONGUE VACCINE VIRUS. J Neuropathol Exp Neurol. 1964 Oct;23:635–659. doi: 10.1097/00005072-196410000-00004. [DOI] [PubMed] [Google Scholar]