Skip to main content
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1982 Jul 31;285(6338):337–340. doi: 10.1136/bmj.285.6338.337

Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission.

J A McCutchan, M W Adler, J R Berrie
PMCID: PMC1498969  PMID: 6807472

Abstract

Since penicillinase-producing Neisseria gonorrhoeae appeared five years ago in West Africa and South-east Asia reported cases have doubled annually in Great Britain, primarily as a result of increasing importation. Importation of penicillinase-producing Neisseria gonorrhoeae has increased exponentially because dramatic expansion of these strains in their regions of origin has led to increasing infection of male air travellers. From 1977 to 1980 infections acquired in Great Britain played only a minor part in the exponential increase. During 1981 the number of indigenous cases increased much more rapidly than imported cases, indicating that these strains have become truly endemic in Great Britain. Currently, identification of patients at high risk and initial treatment with penicillinase-resistant antibiotics offers the best hope of containing the strains. The emergence and rapid spread of penicillinase-producing Neisseria gonorrhoeae shows the international consequences of the abuse of antibiotics.

Full text

PDF
339

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashford W. A., Golash R. G., Hemming V. G. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Sep 25;2(7987):657–658. doi: 10.1016/s0140-6736(76)92467-3. [DOI] [PubMed] [Google Scholar]
  2. Berg S. W., Kilpatrick M. E., Harrison W. O., McCutchan J. A. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979 Sep 6;301(10):509–511. doi: 10.1056/NEJM197909063011001. [DOI] [PubMed] [Google Scholar]
  3. Bijkerk H. Penicillinase-producing gonococci in the Netherlands. Br J Vener Dis. 1980 Aug;56(4):243–243. doi: 10.1136/sti.56.4.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jaffe H. W., Biddle J. W., Johnson S. R., Wiesner P. J. Infections due to penicillinase-producing Neisseria gonorrhoeae in the United States: 1976-1980. J Infect Dis. 1981 Aug;144(2):191–197. doi: 10.1093/infdis/144.2.191. [DOI] [PubMed] [Google Scholar]
  5. Jephcott A. E., Dickgiesser N., McClean A. N. Penicillinase-producing gonococci in Britain. Lancet. 1981 Aug 1;2(8240):247–248. doi: 10.1016/s0140-6736(81)90487-6. [DOI] [PubMed] [Google Scholar]
  6. Johnson D. W., Holmes K. K., Kvale P. A., Halverson C. W., Hirsch W. P. An evaluation of gonorrhea case findings in the chronically infected female. Am J Epidemiol. 1969 Nov;90(5):438–448. doi: 10.1093/oxfordjournals.aje.a121090. [DOI] [PubMed] [Google Scholar]
  7. Nayyar K. C., Michel M. F., Stolz E. Antibiotic sensitivities of gonococci isolated in Rotterdam and results of treatment with cefuroxime. Br J Vener Dis. 1980 Aug;56(4):249–251. doi: 10.1136/sti.56.4.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Percival A., Rowlands J., Corkill J. E., Alergant C. D., Arya O. P., Rees E., Annels E. H. Penicillinase-producing Gonococci in Liverpool. Lancet. 1976 Dec 25;2(8000):1379–1382. doi: 10.1016/s0140-6736(76)91919-x. [DOI] [PubMed] [Google Scholar]
  9. Perine P. L., Morton R. S., Piot P., Siegel M. S., Antal G. M. Epidemiology and treatment of penicillinase-producing Neisseria gonorrhoeae. Sex Transm Dis. 1979 Apr-Jun;6(2 Suppl):152–158. doi: 10.1097/00007435-197904000-00021. [DOI] [PubMed] [Google Scholar]
  10. Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
  11. Rajan V. S., Sng E. H., Pang R., Tan N. J., Thirumoorthy T., Yeo K. L. HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1980 Aug;56(4):255–258. doi: 10.1136/sti.56.4.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rajan V. S., Thirumoorthy T., Tan N. J. Epidemiology of penicillinase-producing Neisseria gonorrhoeae in Singapore. Br J Vener Dis. 1981 Jun;57(3):158–161. doi: 10.1136/sti.57.3.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. van Embden J. D., van Klingeren B., Dessens-Kroon M., van Wijngaarden L. J. Emergence in the Netherlands of penicillinase-producing gonococci carrying "Africa" plasmid in combination with transfer plasmid. Lancet. 1981 Apr 25;1(8226):938–938. doi: 10.1016/s0140-6736(81)91630-5. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES