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. 1982 Nov 13;285(6352):1383–1386. doi: 10.1136/bmj.285.6352.1383

Diuresis or urinary alkalinisation for salicylate poisoning?

L F Prescott, M Balali-Mood, J A Critchley, A F Johnstone, A T Proudfoot
PMCID: PMC1500395  PMID: 6291695

Abstract

Forty-four adults with aspirin poisoning were treated with oral fluids only, standard forced alkaline diuresis, forced diuresis alone, or sodium bicarbonate (alkali) alone. Alkali alone was at least as effective and possibly more effective than forced alkaline diuresis in enhancing salicylate removal. Unlike the diuresis regimens it did not cause fluid retention or biochemical disturbances. The renal excretion of salicylate depends much more on urine pH than flow rate, and forced diuresis alone had little useful effect. In overdosage aspirin causes sodium and fluid retention and may impair renal function. Attempts to force a diuresis are potentially hazardous and the spurious fall in plasma salicylate concentration caused by haemodilution gives a false impression of efficacy. Further studies are required to determine the optimum treatment for salicylate poisoning.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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