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. 1982 Dec 11;285(6356):1686–1688. doi: 10.1136/bmj.285.6356.1686

Erythropoietin and renal function in sickle-cell disease.

A G Morgan, C A Gruber, G R Serjeant
PMCID: PMC1500701  PMID: 6816331

Abstract

The relation between haemoglobin concentration, creatinine clearance, and the serum concentration of erythropoiesis-stimulating factor were assessed in 31 patients with homozygous sickle-cell disease. Haemoglobin concentrations fell significantly with decreasing creatinine clearance (r = 0.58, p less than 0.001) and were positively correlated with the concentration of erythropoiesis-stimulating factor (r = 0.65, p less than 0.001). These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.

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Selected References

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