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. 1982 Dec 11;285(6356):1686–1688. doi: 10.1136/bmj.285.6356.1686

Erythropoietin and renal function in sickle-cell disease.

A G Morgan, C A Gruber, G R Serjeant
PMCID: PMC1500701  PMID: 6816331

Abstract

The relation between haemoglobin concentration, creatinine clearance, and the serum concentration of erythropoiesis-stimulating factor were assessed in 31 patients with homozygous sickle-cell disease. Haemoglobin concentrations fell significantly with decreasing creatinine clearance (r = 0.58, p less than 0.001) and were positively correlated with the concentration of erythropoiesis-stimulating factor (r = 0.65, p less than 0.001). These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexanian R. Erythropoietin excretion in bone marrow failure and hemolytic anemia. J Lab Clin Med. 1973 Sep;82(3):438–445. [PubMed] [Google Scholar]
  2. Caro J., Brown S., Miller O., Murray T., Erslev A. J. Erythropoietin levels in uremic nephric and anephric patients. J Lab Clin Med. 1979 Mar;93(3):449–458. [PubMed] [Google Scholar]
  3. Haddy T. B., Lusher J. M., Hendricks S., Trosko B. K. Erythropoiesis in sickle cell anaemia during acute infection and crisis. Scand J Haematol. 1979 Apr 4;22(4):289–295. doi: 10.1111/j.1600-0609.1979.tb00422.x. [DOI] [PubMed] [Google Scholar]
  4. Hammond D., Shore N., Movassaghi N. Production, utilization and excretion of erythropoietin. I. Chronic anemias. II. Aplastic crisis. 3. Erythropoietic effects of normal plasma. Ann N Y Acad Sci. 1968 Mar 29;149(1):516–527. doi: 10.1111/j.1749-6632.1968.tb15191.x. [DOI] [PubMed] [Google Scholar]
  5. Lertora J. J., Dargon P. A., Rege A. B., Fisher J. W. Studies on a radioimmunoassay for human erythopoietin. J Lab Clin Med. 1975 Jul;86(1):140–151. [PubMed] [Google Scholar]
  6. NAETS J. P., HEUSE A. F. Measurement of erythropoietic stimulating factor in anemic patients with or without renal disease. J Lab Clin Med. 1962 Sep;60:365–374. [PubMed] [Google Scholar]
  7. Okçuoğlu A. Erythropoietin in acute erythroblastopenia of sickle cell anemia. Turk J Pediatr. 1964 Oct;6(4):225–232. [PubMed] [Google Scholar]
  8. Radtke H. W., Claussner A., Erbes P. M., Scheuermann E. H., Schoeppe W., Koch K. M. Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function. Blood. 1979 Oct;54(4):877–884. [PubMed] [Google Scholar]
  9. STOHLMAN F., Jr, BRECHER G. Humoral regulation of erythropoiesis. V. Relationship of plasma erythropoietine level to bone marrow activity. Proc Soc Exp Biol Med. 1959 Jan;100(1):40–43. doi: 10.3181/00379727-100-24516. [DOI] [PubMed] [Google Scholar]
  10. Thomas A. N., Pattison C., Serjeant G. R. Causes of death in sickle-cell disease in Jamaica. 1982 Aug 28-Sep 4Br Med J (Clin Res Ed) 285(6342):633–635. doi: 10.1136/bmj.285.6342.633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wardle D. F., Malpas J. S., Wrigley P. F. Bioassay of erythropoietin using foetal mouse liver cells. Br J Haematol. 1973 Jan;24(1):49–56. doi: 10.1111/j.1365-2141.1973.tb05726.x. [DOI] [PubMed] [Google Scholar]
  12. Zucker S., Lysik R. M., Mohammad G. Erythropoiesis in chronic renal disease. J Lab Clin Med. 1976 Oct;88(4):528–535. [PubMed] [Google Scholar]
  13. de Klerk G., Rosengarten P. C., Vet R. J., Goudsmit R. Serum erythropoietin (EST) titers in anemia. Blood. 1981 Dec;58(6):1164–1170. [PubMed] [Google Scholar]

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