Skip to main content
California Medicine logoLink to California Medicine
. 1970 Mar;112(3):1–7.

Coagulation Factor Analysis in Patients on Long-Term Anticoagulation

Herbert A Perkins, Robert L Biben
PMCID: PMC1501381  PMID: 5451608

Abstract

Ninety studies on 58 patients undergoing chronic warfarin therapy included Quick prothrombin times, partial thromboplastin times, thromboplastin generation tests and assays for clotting factors II, V, VII, VIII, IX, X, XI and XII. The results indicate no benefit from supplementation of the Quick tests by any of these other procedures. It is suggested that the Quick test uniformly performed, using a standard uniform thromboplastin, would be the procedure of choice.

Full text

PDF
3

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER B., WESSLER S. A guide to anticoagulant therapy. Circulation. 1961 Jul;24:123–138. doi: 10.1161/01.cir.24.1.123. [DOI] [PubMed] [Google Scholar]
  2. Askey J. M. Hemorrhage during long-term anticoagulant drug therapy. 3. The relationship of minor to serious bleeding. Calif Med. 1966 Mar;104(3):175–178. [PMC free article] [PubMed] [Google Scholar]
  3. BACHMANN F., DUCKERT F., KOLLER F. The Stuart-Prower factor assay and its clinical significance. Thromb Diath Haemorrh. 1958 May 1;2(1-2):24–38. [PubMed] [Google Scholar]
  4. BELL W. N., ALTON H. G. A brain extract as a substitute for platelet suspensions in the thromboplastin generation test. Nature. 1954 Nov 6;174(4436):880–881. doi: 10.1038/174880a0. [DOI] [PubMed] [Google Scholar]
  5. BORCHGREVINK C. F., POOL J. G., STORMORKEN H. A new assay for factor V (proaccelerin-accelerin) using Russell's viper venom. J Lab Clin Med. 1960 Apr;55:625–632. [PubMed] [Google Scholar]
  6. CATTAN A. D., DENSON K. W. THE INTERACTION OF CONTACT PRODUCT AND FACTOR IX. Thromb Diath Haemorrh. 1964 Apr 15;11:155–166. [PubMed] [Google Scholar]
  7. DENSON K. W. Levels of blood-coagulation factors during anticoagulant therapy with phenindione. Br Med J. 1961 Apr 29;1(5234):1205–1210. doi: 10.1136/bmj.1.5234.1205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOROWITZ H. I., WILCOX W. P., FUJIMOTO M. M. Assay of plasma thromboplastin antecedent (PTA) with artificially depleted normal plasma. Blood. 1963 Jul;22:35–43. [PubMed] [Google Scholar]
  9. HOUGIE C. A simple assay method for factor X (Stuart-Prower factor). Proc Soc Exp Biol Med. 1962 Mar;109:754–756. doi: 10.3181/00379727-109-27328. [DOI] [PubMed] [Google Scholar]
  10. MICHAELS M. M. Bleeding from occult tumors during anticoagulant therapy. Circulation. 1962 May;25:804–806. doi: 10.1161/01.cir.25.5.804. [DOI] [PubMed] [Google Scholar]
  11. OWREN P. A. Thrombotest. A new method for controlling anticoagulant therapy. Lancet. 1959 Nov 7;2(7106):754–758. doi: 10.1016/s0140-6736(59)90857-8. [DOI] [PubMed] [Google Scholar]
  12. Perkins H. A. Plasmapheresis of the patient as a method for achieving effective levels of plasma coagulation factors using fresh frozen plasma. Transfusion. 1966 Jul-Aug;6(4):293–301. doi: 10.1111/j.1537-2995.1966.tb04742.x. [DOI] [PubMed] [Google Scholar]
  13. Poller L. A national standard for anticoagulant therapy. The Manchester comparative reagent. Lancet. 1967 Mar 4;1(7488):491–493. doi: 10.1016/s0140-6736(67)91109-9. [DOI] [PubMed] [Google Scholar]
  14. RAPAPORT S. I., AMES S. B. Relation between levels of plasma thromboplastin component (PTC) and prothrombin times by the P&P and Quick methods in patients receiving warfarin. N Engl J Med. 1962 Jul 19;267:125–130. doi: 10.1056/NEJM196207192670303. [DOI] [PubMed] [Google Scholar]
  15. RAPAPORT S. I., SCHIFFMAN S., PATCH M. J., WARE A. G. A simple, specific one-stage assay for plasma thromboplastin antecedent activity. J Lab Clin Med. 1961 May;57:771–780. [PubMed] [Google Scholar]
  16. RODMAN T., PASTOR B. H., FAWCETT K. C. A comparison of laboratory methods for the control of anticoagulant therapy with prothrombinopenic agents. I. The Quick one-stage procedure, the prothrombin and proconvertin test and the one-stage determination of true prothrombin activity. Am J Med. 1961 Oct;31:547–554. doi: 10.1016/0002-9343(61)90138-3. [DOI] [PubMed] [Google Scholar]
  17. VERSTRAETE M., CLARK P. A., WRIGHT I. S. Use of different tissue thromboplastins in the control of anticoagulant therapy. Circulation. 1957 Aug;16(2):213–226. doi: 10.1161/01.cir.16.2.213. [DOI] [PubMed] [Google Scholar]

Articles from California Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES