Abstract
Labetalol has been successful in treating hypertension, and few side effects have been reported, although there have been cases of muscle pain during treatment. A patient with essential hypertension treated with labetalol 600 mg daily complained of muscle pains, particularly in the legs. No neurological abnormality was found, but the activity of muscle enzymes in the blood was high. Findings on electromyography were compatible with myositis and electron microscopical findings suggested toxic myopathy. Labetalol was stopped for 10 days, and the muscle pain disappeared and enzyme activity returned to normal. When labetalol was restarted the pain returned and enzyme activities rose. Myopathy should be considered in patients experiencing muscle pain after treatment with labetalol.
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- Andersson O., Berglund G., Hansson L. Anti-hypertensive action, time of onset and effects on carbohydrate metabolism of labetalol. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):757–761. [PubMed] [Google Scholar]
- Bolli P., Waal-Manning H. J., Simpson F. O., Seeman H. M. Treatment of hypertension with labetalol. N Z Med J. 1977 Dec 28;86(602):557–563. [PubMed] [Google Scholar]
- Farmer J. B., Kennedy I., Levy G. P., Marshall R. J. Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors. Br J Pharmacol. 1972 Aug;45(4):660–675. doi: 10.1111/j.1476-5381.1972.tb08125.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jennings K., Parsons V. A study of labetalol in patients of European, West Indian and West African origin. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):773–775. [PubMed] [Google Scholar]
- Macdonald R. D., Engel A. G. Experimental chloroquine myopathy. J Neuropathol Exp Neurol. 1970 Jul;29(3):479–499. doi: 10.1097/00005072-197007000-00010. [DOI] [PubMed] [Google Scholar]