Abstract
The efficacy of oral urea in producing a sufficiently high osmotic diuresis was tested in seven patients with the syndrome of inappropriate secretion of antidiuretic hormone. In all patients urea corrected the hyponatraemia despite a normal fluid intake. Five patients were controlled (serum sodium concentration greater than 128 mmol(mEq)/1) with a dose of 30 g urea daily, and two with 60 g daily. The patients who needed 30 g drank 1-2 1 of fluid daily, while those who needed 60 g drank up to 3.1 per day. No major side effects were noted, even after treatment periods of up to 270 days. These findings suggest that urea is a safe and efficacious treatment of the syndrome of inappropriate secretion of antidiuretic hormone.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bartter F. C., Schwartz W. B. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967 May;42(5):790–806. doi: 10.1016/0002-9343(67)90096-4. [DOI] [PubMed] [Google Scholar]
- De Troyer A. Demeclocycline. Treatment for syndrome of inappropriate antidiuretic hormone secretion. JAMA. 1977 Jun 20;237(25):2723–2726. doi: 10.1001/jama.237.25.2723. [DOI] [PubMed] [Google Scholar]
- Decaux G., Brimioulle S., Genette F., Mockel J. Treatment of the syndrome of inappropriate secretion of antidiuretic hormone by urea. Am J Med. 1980 Jul;69(1):99–106. doi: 10.1016/0002-9343(80)90506-9. [DOI] [PubMed] [Google Scholar]
- Decaux G., Genette F., Mockel J. Hypouremia in the syndrome of inappropriate secretion of antidiuretic hormone. Ann Intern Med. 1980 Nov;93(5):716–717. doi: 10.7326/0003-4819-93-5-716. [DOI] [PubMed] [Google Scholar]
- Decaux G., Unger J., Mockel J. Urea therapy for inappropriate antidiuretic hormone secretion from tuberculous meningitis. JAMA. 1980 Aug 8;244(6):589–590. [PubMed] [Google Scholar]
- Decaux G., Waterlot Y., Genette F., Mockel J. Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with furosemide. N Engl J Med. 1981 Feb 5;304(6):329–330. doi: 10.1056/NEJM198102053040605. [DOI] [PubMed] [Google Scholar]
- Forrest J. N., Jr, Cox M., Hong C., Morrison G., Bia M., Singer I. Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med. 1978 Jan 26;298(4):173–177. doi: 10.1056/NEJM197801262980401. [DOI] [PubMed] [Google Scholar]
- JAVID M., SETTLAGE P. Effect of urea on cerebrospinal fluid pressure in human subjects; preliminary report. J Am Med Assoc. 1956 Mar 17;160(11):943–949. doi: 10.1001/jama.1956.02960460021006. [DOI] [PubMed] [Google Scholar]