Abstract
In experiments on the isolated small intestine of the guinea-pig, morphine inhibited the release of acetylcholine (ACh) into the bath fluid. Experimental evidence is presented which suggests that the reduced release of ACh could not be explained by an inhibition of the synthesis of ACh, nor by stabilization of the bound form of ACh in the tissue. Apparently morphine reduces the excitability of postganglionic structures and thereby the liberation of ACh from nerve endings during the process of excitation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BRODKIN E., ELLIOTT K. A. Binding of acetylcholine. Am J Physiol. 1953 Jun;173(3):437–442. doi: 10.1152/ajplegacy.1953.173.3.437. [DOI] [PubMed] [Google Scholar]
- Chang H. C., Gaddum J. H. Choline esters in tissue extracts. J Physiol. 1933 Oct 6;79(3):255–285. doi: 10.1113/jphysiol.1933.sp003049. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feldberg W., Lin R. C. Synthesis of acetylcholine in the wall of the digestive tract. J Physiol. 1950 Apr 15;111(1-2):96–118. doi: 10.1113/jphysiol.1950.sp004467. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KUMAGAI H., EBASHI S., TAKEDA F. Studies on choline acetylase. I. Jpn J Pharmacol. 1954 Sep;4(1):24–31. doi: 10.1254/jjp.4.24. [DOI] [PubMed] [Google Scholar]
- Mann P. J., Tennenbaum M., Quastel J. H. Acetylcholine metabolism in the central nervous system: The effects of potassium and other cations on acetylcholine liberation. Biochem J. 1939 May;33(5):822–835. doi: 10.1042/bj0330822. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHAUMANN O., GIOVANNINI M., JOCHUM K. Morphinähnlich wirkende Analgetika und Darmmotorik. I. Spasmolyse und Peristaltik. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1952;215(5-6):460–468. [PubMed] [Google Scholar]
- SCHAUMANN W. The paralysing action of morphine on the guinea-pig ileum. Br J Pharmacol Chemother. 1955 Dec;10(4):456–461. doi: 10.1111/j.1476-5381.1955.tb00105.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vartiainen A. Does vagus stimulation cause an increase in the acetylcholine content of heart muscle? J Physiol. 1934 Oct 17;82(3):282–292. doi: 10.1113/jphysiol.1934.sp003181. [DOI] [PMC free article] [PubMed] [Google Scholar]