Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1995 Jan;72(1):29–32. doi: 10.1136/adc.72.1.29

Genetic difference in HLA-DR phenotypes between coeliac disease and transitory gluten intolerance.

R Meuli 1, W J Pichler 1, H Gaze 1, M J Lentze 1
PMCID: PMC1510961  PMID: 7717732

Abstract

Genetic differences in HLA phenotypes were studied in coeliac disease to investigate why some patients do not react with mucosal damage after gluten challenge. Forty five children with coeliac disease and 16 with transitory gluten intolerance were typed; 76 subjects served as controls. HLA phenotypes in children with coeliac disease had significantly higher proportions of DR3/X and DR5/7 than controls (48.8% v 11.8% and 26.7% v 5.3%). Children with transitory gluten intolerance had lower DR3/X (43.8%) than children with coeliac disease and there were no DR5/7 phenotypes. Further analysis of similarly well defined cases might show whether genetic differences in the DR3/X and DR5/7 phenotypes can serve as a marker for the permanence of gluten intolerance.

Full text

PDF
30

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bürgin-Wolff A., Berger R., Gaze H., Huber H., Lentze M. J., Nusslé D. IgG, IgA and IgE gliadin antibody determinations as screening test for untreated coeliac disease in children, a multicentre study. Eur J Pediatr. 1989 Apr;148(6):496–502. doi: 10.1007/BF00441541. [DOI] [PubMed] [Google Scholar]
  2. Bürgin-Wolff A., Gaze H., Hadziselimovic F., Huber H., Lentze M. J., Nusslé D., Reymond-Berthet C. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug;66(8):941–947. doi: 10.1136/adc.66.8.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DICKE W. K., WEIJERS H. A., VAN DE KAMER J. H. Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr. 1953 Jan;42(1):34–42. doi: 10.1111/j.1651-2227.1953.tb05563.x. [DOI] [PubMed] [Google Scholar]
  4. DeMarchi M., Borelli I., Olivetti E., Richiardi P., Wright P., Ansaldi N., Barbera C., Santini B. Two HLA-D and DR alleles are associated with coeliac disease. Tissue Antigens. 1979 Oct;14(4):309–316. doi: 10.1111/j.1399-0039.1979.tb00854.x. [DOI] [PubMed] [Google Scholar]
  5. Granditsch G., Ludwig H., Polymenidis Z., Wick G. Letter: Coeliac disease and HL-A8. Lancet. 1973 Oct 20;2(7834):908–909. doi: 10.1016/s0140-6736(73)92034-5. [DOI] [PubMed] [Google Scholar]
  6. Herrera M., Chertkoff L., Palavecino E., Mota A., Guala M. C., Fainboim L., Satz M. L. Restriction fragment length polymorphism in HLA class II genes of Latin-American Caucasian celiac disease patients. Hum Immunol. 1989 Dec;26(4):272–280. doi: 10.1016/0198-8859(89)90005-0. [DOI] [PubMed] [Google Scholar]
  7. Kagnoff M. F., Harwood J. I., Bugawan T. L., Erlich H. A. Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6274–6278. doi: 10.1073/pnas.86.16.6274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lundin K. E., Scott H., Hansen T., Paulsen G., Halstensen T. S., Fausa O., Thorsby E., Sollid L. M. Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med. 1993 Jul 1;178(1):187–196. doi: 10.1084/jem.178.1.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McNeish A. S., Rolles C. J., Arthur L. J. Criteria for diagnosis of temporary gluten intolerance. Arch Dis Child. 1976 Apr;51(4):275–278. doi: 10.1136/adc.51.4.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mearin M. L., Biemond I., Peña A. S., Polanco I., Vazquez C., Schreuder G. T., de Vries R. R., van Rood J. J. HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease. Gut. 1983 Jun;24(6):532–537. doi: 10.1136/gut.24.6.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mearin M. L., Bouquet J., Mourad N., Schoorel E., Sinaasappel M., Biemond I., Schreuder G. M., Peña A. S., van Gelderen H. H., van Rood J. J. HLA-DR antigens and phenotypes in Dutch coeliac children and their families. Clin Genet. 1985 Jan;27(1):45–50. doi: 10.1111/j.1399-0004.1985.tb00182.x. [DOI] [PubMed] [Google Scholar]
  12. Mearin M. L., Koninckx C. R., Biemond I., Polanco I., Peña A. S. Influence of genetic factors on the serum levels of antigliadin antibodies in celiac disease. J Pediatr Gastroenterol Nutr. 1984 Jun;3(3):373–377. doi: 10.1097/00005176-198406000-00012. [DOI] [PubMed] [Google Scholar]
  13. Morellini M., Trabace S., Mazzilli M. C., Lulli P., Cappellacci S., Bonamico M., Margarit I., Gandini E. A study of HLA class II antigens in an Italian paediatric population with coeliac disease. Dis Markers. 1988 Mar;6(1):23–28. [PubMed] [Google Scholar]
  14. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child. 1990 Aug;65(8):909–911. doi: 10.1136/adc.65.8.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Selby W. S., Janossy G., Bofill M., Jewell D. P. Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin Exp Immunol. 1983 Apr;52(1):219–228. [PMC free article] [PubMed] [Google Scholar]
  16. Sollid L. M., Markussen G., Ek J., Gjerde H., Vartdal F., Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med. 1989 Jan 1;169(1):345–350. doi: 10.1084/jem.169.1.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sollid L. M., Thorsby E. The primary association of celiac disease to a given HLA-DQ alpha/beta heterodimer explains the divergent HLA-DR associations observed in various Caucasian populations. Tissue Antigens. 1990 Sep;36(3):136–137. doi: 10.1111/j.1399-0039.1990.tb01816.x. [DOI] [PubMed] [Google Scholar]
  18. Spurkland A., Rønningen K. S., Leivestad T., Vartdal F., Thorsby E. HLA-DR-DQ haplotype frequencies in a Norwegian population. Transplant Proc. 1992 Feb;24(1):298–299. [PubMed] [Google Scholar]
  19. Stern M., Fischer K., Grüttner R. Immunofluorescent serum gliadin antibodies in children with coeliac disease and various malabsorptive disorders. I. Technique, clinical evaluation and diagnostic use of a gliadin antibody assay using pyruvic aldehyde-treated human red cells. Eur J Pediatr. 1979 Mar 1;130(3):155–164. doi: 10.1007/BF00455261. [DOI] [PubMed] [Google Scholar]
  20. Stokes P. L., Asquith P., Holmes G. K., Mackintosh P., Cooke W. T. Histocompatibility antigens associated with adult coeliac disease. Lancet. 1972 Jul 22;2(7769):162–164. doi: 10.1016/s0140-6736(72)91330-x. [DOI] [PubMed] [Google Scholar]
  21. Tosi R., Vismara D., Tanigaki N., Ferrara G. B., Cicimarra F., Buffolano W., Follo D., Auricchio S. Evidence that celiac disease is primarily associated with a DC locus allelic specificity. Clin Immunol Immunopathol. 1983 Sep;28(3):395–404. doi: 10.1016/0090-1229(83)90106-x. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES