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. 1995 Nov;73(5):423–426. doi: 10.1136/adc.73.5.423

Airway reactivity in parents of infants and young children with recurrent wheeze: a case-control study.

F Rusconi 1, F Nizardo 1, I Cerveri 1, M Castagneto 1, F Fanfulla 1, L Gagliardi 1, L Pugni 1
PMCID: PMC1511373  PMID: 8554359

Abstract

Increased airway reactivity has been found in family members of school age children and adults with asthma. As the relation between recurrent wheeze in infancy and bronchial reactivity is not yet clear, it was decided to test bronchial reactivity to methacholine in both parents of 50 preschool age children with recurrent wheeze and in 200 population based controls matched for sex, age, smoking habits, and atopy. Wheezy children fulfilled the following criteria: first attack of wheezing before the age of 2 years, at least four wheezing episodes triggered by a respiratory infection, negative skin prick tests, and no symptoms related to allergy. Four parents and five controls did not undergo the methacholine challenge because their forced expiratory volume in one second was < 80% of the predicted value. Methacholine reactivity was not significantly different in parents and controls. In summary, an increased bronchial responsiveness was not found in parents of infants and young children with recurrent wheeze triggered by infection.

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Selected References

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  1. Camilli A. E., Holberg C. J., Wright A. L., Taussig L. M. Parental childhood respiratory illness and respiratory illness in their infants. Group Health Medical Associates. Pediatr Pulmonol. 1993 Nov;16(5):275–280. doi: 10.1002/ppul.1950160502. [DOI] [PubMed] [Google Scholar]
  2. Cerveri I., Bruschi C., Zoia M. C., Maccarini L., Grassi M., Lebowitz M. D., Rampulla C., Grassi C. Smoking habit and bronchial reactivity in normal subjects. A population-based study. Am Rev Respir Dis. 1989 Jul;140(1):191–196. doi: 10.1164/ajrccm/140.1.191. [DOI] [PubMed] [Google Scholar]
  3. Cerveri I., Bruschi C., Zoia M. C., Zanon P., Maccarini L., Grassi M., Rampulla C. Distribution of bronchial nonspecific reactivity in the general population. Chest. 1988 Jan;93(1):26–30. doi: 10.1378/chest.93.1.26. [DOI] [PubMed] [Google Scholar]
  4. Dupont W. D. Power calculations for matched case-control studies. Biometrics. 1988 Dec;44(4):1157–1168. [PubMed] [Google Scholar]
  5. Godden D. J., Ross S., Abdalla M., McMurray D., Douglas A., Oldman D., Friend J. A., Legge J. S., Douglas J. G. Outcome of wheeze in childhood. Symptoms and pulmonary function 25 years later. Am J Respir Crit Care Med. 1994 Jan;149(1):106–112. doi: 10.1164/ajrccm.149.1.8111567. [DOI] [PubMed] [Google Scholar]
  6. Gurwitz D., Mindorff C., Levison H. Increased incidence of bronchial reactivity in children with a history of bronchiolitis. J Pediatr. 1981 Apr;98(4):551–555. doi: 10.1016/s0022-3476(81)80758-5. [DOI] [PubMed] [Google Scholar]
  7. Hargreave F. E., Dolovich J., O'Byrne P. M., Ramsdale E. H., Daniel E. E. The origin of airway hyperresponsiveness. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):825–832. doi: 10.1016/0091-6749(86)90226-5. [DOI] [PubMed] [Google Scholar]
  8. Hopp R. J., Bewtra A. K., Biven R., Nair N. M., Townley R. G. Bronchial reactivity pattern in nonasthmatic parents of asthmatics. Ann Allergy. 1988 Sep;61(3):184–186. [PubMed] [Google Scholar]
  9. Hopp R. J., Bewtra A. K., Nair N. M., Watt G. D., Townley R. G. Methacholine inhalation challenge studies in a selected pediatric population. Am Rev Respir Dis. 1986 Nov;134(5):994–998. doi: 10.1164/arrd.1986.134.5.994. [DOI] [PubMed] [Google Scholar]
  10. Hopp R. J., Bewtra A., Nair N. M., Townley R. G. The effect of age on methacholine response. J Allergy Clin Immunol. 1985 Oct;76(4):609–613. doi: 10.1016/0091-6749(85)90783-3. [DOI] [PubMed] [Google Scholar]
  11. Kopec J. A., Esdaile J. M. Bias in case-control studies. A review. J Epidemiol Community Health. 1990 Sep;44(3):179–186. doi: 10.1136/jech.44.3.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. König P., Godfrey S. Exercise-induced bronchial lability and atopic status of families of infants with wheezy bronchitis. Arch Dis Child. 1973 Dec;48(12):942–946. doi: 10.1136/adc.48.12.942. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Longo G., Strinati R., Poli F., Fumi F. Genetic factors in nonspecific bronchial hyperreactivity. An epidemiologic study. Am J Dis Child. 1987 Mar;141(3):331–334. doi: 10.1001/archpedi.1987.04460030109037. [DOI] [PubMed] [Google Scholar]
  14. Martinez F. D., Morgan W. J., Wright A. L., Holberg C., Taussig L. M. Initial airway function is a risk factor for recurrent wheezing respiratory illnesses during the first three years of life. Group Health Medical Associates. Am Rev Respir Dis. 1991 Feb;143(2):312–316. doi: 10.1164/ajrccm/143.2.312. [DOI] [PubMed] [Google Scholar]
  15. Mertsola J., Ziegler T., Ruuskanen O., Vanto T., Koivikko A., Halonen P. Recurrent wheezy bronchitis and viral respiratory infections. Arch Dis Child. 1991 Jan;66(1):124–129. doi: 10.1136/adc.66.1.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pattemore P. K., Johnston S. L., Bardin P. G. Viruses as precipitants of asthma symptoms. I. Epidemiology. Clin Exp Allergy. 1992 Mar;22(3):325–336. doi: 10.1111/j.1365-2222.1992.tb03094.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Pifferi M., Bertelloni C., Viegi G., Baldini M., Baldini G. Airway response to a bronchodilator in healthy parents of infants with bronchiolitis. Chest. 1994 Mar;105(3):706–709. doi: 10.1378/chest.105.3.706. [DOI] [PubMed] [Google Scholar]
  18. Rijcken B., Schouten J. P., Mensinga T. T., Weiss S. T., De Vries K., Van der Lende R. Factors associated with bronchial responsiveness to histamine in a population sample of adults. Am Rev Respir Dis. 1993 Jun;147(6 Pt 1):1447–1453. doi: 10.1164/ajrccm/147.6_Pt_1.1447. [DOI] [PubMed] [Google Scholar]
  19. Rijcken B., Schouten J. P., Weiss S. T., Meinesz A. F., de Vries K., van der Lende R. The distribution of bronchial responsiveness to histamine in symptomatic and in asymptomatic subjects. A population-based analysis of various indices of responsiveness. Am Rev Respir Dis. 1989 Sep;140(3):615–623. doi: 10.1164/ajrccm/140.3.615. [DOI] [PubMed] [Google Scholar]
  20. Sporik R., Holgate S. T., Cogswell J. J. Natural history of asthma in childhood--a birth cohort study. Arch Dis Child. 1991 Sep;66(9):1050–1053. doi: 10.1136/adc.66.9.1050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Townley R. G., Bewtra A. K., Nair N. M., Brodkey F. D., Watt G. D., Burke K. M. Methacholine inhalation challenge studies. J Allergy Clin Immunol. 1979 Dec;64(6 Pt 2):569–574. doi: 10.1016/0091-6749(79)90014-9. [DOI] [PubMed] [Google Scholar]
  22. Townley R. G., Ryo U. Y., Kolotkin B. M., Kang B. Bronchial sensitivity to methacholine in current and former asthmatic and allergic rhinitis patients and control subjects. J Allergy Clin Immunol. 1975 Dec;56(6):429–442. doi: 10.1016/0091-6749(75)90061-5. [DOI] [PubMed] [Google Scholar]
  23. Voter K. Z., Henry M. M., Stewart P. W., Henderson F. W. Lower respiratory illness in early childhood and lung function and bronchial reactivity in adolescent males. Am Rev Respir Dis. 1988 Feb;137(2):302–307. doi: 10.1164/ajrccm/137.2.302. [DOI] [PubMed] [Google Scholar]
  24. Wilson N. M. Wheezy bronchitis revisited. Arch Dis Child. 1989 Aug;64(8):1194–1199. doi: 10.1136/adc.64.8.1194. [DOI] [PMC free article] [PubMed] [Google Scholar]

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