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. 1996 Nov;75(5):427–431. doi: 10.1136/adc.75.5.427

Model of normal prepubertal growth.

N K Thalange 1, P J Foster 1, M S Gill 1, D A Price 1, P E Clayton 1
PMCID: PMC1511779  PMID: 8957957

Abstract

Growth over the short term is a highly complex non-linear process. Contrasting models of short term growth have been proposed which include periodic growth cycles versus abrupt growth spurts with intervening growth arrest ('saltation and stasis'). The variability of short term growth has been characterised from a study of 46 healthy prepubertal children measured three times a week over one academic year using a combination of descriptive statistical approaches and regression modelling. Growth in childhood over one year is represented by a biphasic process comprising three to six unpredictable growth spurts, each of mean length 56 days (range 13-155 days), separated by periods of stasis (less than or equal to 0.05 cm height increment over more than seven days), each lasting a mean of 18 days (range 8-52 days) and accounting for at least 20% of the period of observation. This is superimposed on strong seasonal trends in growth with a declining growth rate over the autumn months reaching a nadir in midwinter, followed by a growth spurt in the spring. Human growth over short periods is therefore a discontinuous, irregular, and unpredictable process.

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Selected References

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  1. Butler G. E., McKie M., Ratcliffe S. G. The cyclical nature of prepubertal growth. Ann Hum Biol. 1990 May-Jun;17(3):177–198. doi: 10.1080/03014469000000952. [DOI] [PubMed] [Google Scholar]
  2. Freeman J. V., Cole T. J., Chinn S., Jones P. R., White E. M., Preece M. A. Cross sectional stature and weight reference curves for the UK, 1990. Arch Dis Child. 1995 Jul;73(1):17–24. doi: 10.1136/adc.73.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Greco L., Capasso A., De Fusco C., Paludetto R. Pulsatile weight increases in very low birthweight babies appropriate for gestational age. Arch Dis Child. 1990 Apr;65(4 Spec No):373–376. doi: 10.1136/adc.65.4_spec_no.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greco L., Santamaria F., Salvatore D., de Ritis G. Growth dynamics in cystic fibrosis. Acta Paediatr. 1993 Mar;82(3):254–260. doi: 10.1111/j.1651-2227.1993.tb12654.x. [DOI] [PubMed] [Google Scholar]
  5. Greco L., Tipo V., Di Donato F., Mayer M. Pulsatile growth pattern during catch-up growth in childhood coeliac disease. Acta Paediatr. 1994 Jul;83(7):724–729. doi: 10.1111/j.1651-2227.1994.tb13127.x. [DOI] [PubMed] [Google Scholar]
  6. Heinrichs C., Munson P. J., Counts D. R., Cutler G. B., Jr, Baron J. Patterns of human growth. Science. 1995 Apr 21;268(5209):442–447. doi: 10.1126/science.7716552. [DOI] [PubMed] [Google Scholar]
  7. Hermanussen M., Geiger-Benoit K., Burmeister J., Sippell W. G. Periodical changes of short term growth velocity ('mini growth spurts') in human growth. Ann Hum Biol. 1988 Mar-Apr;15(2):103–109. doi: 10.1080/03014468800009521. [DOI] [PubMed] [Google Scholar]
  8. Hermanussen M., Geiger-Benoit K., Sippell W. G. GH deficient children receiving GH replacement do not grow during intermittent infectious illness. Acta Paediatr Scand. 1986 Jul;75(4):601–604. doi: 10.1111/j.1651-2227.1986.tb10258.x. [DOI] [PubMed] [Google Scholar]
  9. Klein K. O., Munson P. J., Bacher J. D., Cutler G. B., Jr, Baron J. Linear growth in the rabbit is continuous, not saltatory. Endocrinology. 1994 Mar;134(3):1317–1320. doi: 10.1210/endo.134.3.8119172. [DOI] [PubMed] [Google Scholar]
  10. Lampl M., Cameron N., Veldhuis J. D., Johnson M. L. Response. Science. 1995 Apr 21;268(5209):445–447. doi: 10.1126/science.268.5209.445. [DOI] [PubMed] [Google Scholar]
  11. Lampl M., Johnson M. L. A case study of daily growth during adolescence: a single spurt or changes in the dynamics of saltatory growth? Ann Hum Biol. 1993 Nov-Dec;20(6):595–603. doi: 10.1080/03014469300003002. [DOI] [PubMed] [Google Scholar]
  12. Lampl M., Veldhuis J. D., Johnson M. L. Saltation and stasis: a model of human growth. Science. 1992 Oct 30;258(5083):801–803. doi: 10.1126/science.1439787. [DOI] [PubMed] [Google Scholar]
  13. Marshall W. A., Swan A. V. Seasonal variation in growth rates of normal and blind children. Hum Biol. 1971 Dec;43(4):502–516. [PubMed] [Google Scholar]
  14. Tanner J. M., Whitehouse R. H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child. 1966 Dec;41(220):613–635. doi: 10.1136/adc.41.220.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Thalange N. K., Gill M. S., Gill L., Whatmore A. J., Addison G. M., Price D. A., Clayton P. E. Infradian rhythms in urinary growth hormone excretion. J Clin Endocrinol Metab. 1996 Jan;81(1):100–106. doi: 10.1210/jcem.81.1.8550735. [DOI] [PubMed] [Google Scholar]
  16. Togo M., Togo T. Time-series analysis of stature and body weight in five siblings. Ann Hum Biol. 1982 Sep-Oct;9(5):425–440. doi: 10.1080/03014468200005961. [DOI] [PubMed] [Google Scholar]
  17. Voss L. D., Bailey B. J., Cumming K., Wilkin T. J., Betts P. R. The reliability of height measurement (the Wessex Growth Study). Arch Dis Child. 1990 Dec;65(12):1340–1344. doi: 10.1136/adc.65.12.1340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wales J. K., Gibson A. T. Short-term growth: rhythms, chaos, or noise? Arch Dis Child. 1994 Jul;71(1):84–89. doi: 10.1136/adc.71.1.84. [DOI] [PMC free article] [PubMed] [Google Scholar]

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