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. 1965 May;102(5):344–352.

Viruses and Cancer—A Review

Robert M McAllister
PMCID: PMC1515879  PMID: 14290931

Abstract

The answer to the important question, “Do viruses play a role in human cancer?” is still unknown. Although many scientists think that they may play a role, straightforward attempts to isolate human tumor viruses in animals or in tissue cultures have failed. Possibly the most sensitive test object, newborn human infants, of course cannot be used as test objects, and this may explain the failure to isolate human tumor viruses. At present, it would appear that the best means of tackling the problem of viral-induced carcinogenesis is to study the basic characteristics of known tumor viruses and the basic aspects of their interactions with cells. Both RNA-containing and DNA-containing viruses, two obviously different classes of virus, can cause cancer and therefore both classes must be studied in order to obtain a complete picture of the role of viruses in causing cancer in animals and cell transformation in vitro. Such basic studies already have yielded information of great importance to general biology.

A number of exciting developments have occurred in the area of virus-induced cancer. One of these is the oncogenic capacity in hamsters of certain human adenoviruses, and an intensive probe of their possible role in human cancer is in progress. Another is the detection by electron microscopy of virus-like particles in the tissues and serum of patients with leukemia.

Rigid criteria have been suggested to establish etiologic significance of viruses recovered from human cancer tissues and of the virus-like particles observed by electron microscopy in serum or malignant tissues from cancer patients.

If viruses are eventually found to play a role in human cancer, then perhaps the disease can be prevented by vaccines and treated with antiviral substances.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABEL P., CRAWFORD L. V. Physical characteristics of polyoma virus. III. Correlation with biological activities. Virology. 1963 Apr;19:470–474. doi: 10.1016/0042-6822(63)90040-0. [DOI] [PubMed] [Google Scholar]
  2. ALMEIDA J. D., HASSELBACK R. C., HAM A. W. VIRUS-LIKE PARTICLES IN BLOOD OF TWO ACUTE LEUKEMIA PATIENTS. Science. 1963 Dec 13;142(3598):1487–1489. doi: 10.1126/science.142.3598.1487. [DOI] [PubMed] [Google Scholar]
  3. ARMSTRONG D., OKUYAN M., HUEBNER R. J. COMPLEMENT-FIXING ANTIGENS IN TISSUE CULTURES OF AVIAN LEUCOSIS VIRUSES. Science. 1964 Jun 26;144(3626):1584–1584. doi: 10.1126/science.144.3626.1584. [DOI] [PubMed] [Google Scholar]
  4. AXELROD D., HABEL K., BOLTON E. T. POLYOMA VIRUS GENETIC MATERIAL IN A VIRUS-FREE POLYOMA-INDUCED TUMOR. Science. 1964 Dec 11;146(3650):1466–1469. doi: 10.1126/science.146.3650.1466. [DOI] [PubMed] [Google Scholar]
  5. BALUDA M. A., GOETZ I. E. Morphological conversion of cell cultures by avian myeloblastosis virus. Virology. 1961 Oct;15:185–199. doi: 10.1016/0042-6822(61)90234-3. [DOI] [PubMed] [Google Scholar]
  6. BELL T. M., MASSIE A., ROSS M. G., WILLIAMS M. C. ISOLATION OF A REOVIRUS FROM A CASE OF BURKITT'S LYMPHOMA. Br Med J. 1964 May 9;1(5392):1212–1213. doi: 10.1136/bmj.1.5392.1212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BURGER C. L., HARRIS W. W., ANDERSON N. G., BARTLETT T. W., KNISELEY R. M. VIRUS-LIKE PARTICLES IN HUMAN LEUKEMIC PLASMA. Proc Soc Exp Biol Med. 1964 Jan;115:151–156. doi: 10.3181/00379727-115-28856. [DOI] [PubMed] [Google Scholar]
  8. CRAWFORD L. V. The physical characteristics of polyoma virus. II. The nucleic acid. Virology. 1963 Mar;19:279–282. doi: 10.1016/0042-6822(63)90065-5. [DOI] [PubMed] [Google Scholar]
  9. DALLDORF G., BERGAMINI F. UNIDENTIFIED, FILTRABLE AGENTS ISOLATED FROM AFRICAN CHILDREN WITH MALIGNANT LYMPHOMAS. Proc Natl Acad Sci U S A. 1964 Feb;51:263–265. doi: 10.1073/pnas.51.2.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. DMOCHOWSKI L., GREY C. E., SYKES J. A., SHULLENBERGER C. C., HOWE C. D. Studies on human leukemia. Proc Soc Exp Biol Med. 1959 Aug-Sep;101:686–690. doi: 10.3181/00379727-101-25062. [DOI] [PubMed] [Google Scholar]
  11. DULBECCO R. TRANSFORMATION OF CELLS IN VITRO BY DNA-CONTAINING VIRUSES. JAMA. 1964 Nov 23;190:721–726. doi: 10.1001/jama.1964.03070210027005. [DOI] [PubMed] [Google Scholar]
  12. EDDY B. E., BORMAN G. S., BERKELEY W. H., YOUNG R. D. Tumors induced in hamsters by injection of rhesus monkey kidney cell extracts. Proc Soc Exp Biol Med. 1961 May;107:191–197. doi: 10.3181/00379727-107-26576. [DOI] [PubMed] [Google Scholar]
  13. EPSTEIN M. A., WOODALL J. P., THOMSON A. D. LYMPHOBLASTIC LYMPHOMA IN BONE-MARROW OF AFRICAN GREEN MONKEYS (CERCOPITHECUS AETHIOPS) INOCULATED WITH BIOPSY MATERIAL FROM A CHILD WITH BURKITT'S LYMPHOMA. Lancet. 1964 Aug 8;2(7354):288–291. doi: 10.1016/s0140-6736(64)93050-8. [DOI] [PubMed] [Google Scholar]
  14. GIRARDI A. J., HILLEMAN M. R., ZWICKEY R. E. TESTS IN HAMSTERS FOR ONCOGENIC QUALITY OF ORDINARY VIRUSES INCLUDING ADENOVIRUS TYPE 7. Proc Soc Exp Biol Med. 1964 Apr;115:1141–1150. doi: 10.3181/00379727-115-29138. [DOI] [PubMed] [Google Scholar]
  15. GREEN M., PINA M. Similarity of DNAs isolated from tumor-inducing viruses of human and animal origin. Proc Natl Acad Sci U S A. 1963 Jul;50:44–46. doi: 10.1073/pnas.50.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. HABEL K. Resistance of polyoma virus immune animals to transplanted polyoma tumors. Proc Soc Exp Biol Med. 1961 Apr;106:722–725. doi: 10.3181/00379727-106-26453. [DOI] [PubMed] [Google Scholar]
  17. HANAFUSA H., HANAFUSA T., RUBIN H. The defectiveness of Rous sarcoma virus. Proc Natl Acad Sci U S A. 1963 Apr;49:572–580. doi: 10.1073/pnas.49.4.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. HEINE U., DE THE G., ISHIGURO H., SOMMER J. R., BEARD D., BEARD J. W. Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. II. Nephroblastoma (Wilms' tumor): ultrastructure. J Natl Cancer Inst. 1962 Jul;29:41–105. [PubMed] [Google Scholar]
  19. HILLEMAN M. R. PROSPECTS FOR THE ROLE OF VIRUSES IN HUMAN MALIGNANCY. Health Lab Sci. 1964 Apr;1:70–78. [PubMed] [Google Scholar]
  20. HUEBNER R. J., PEREIRA H. G., ALLISON A. C., HOLLINSHEAD A. C., TURNER H. C. PRODUCTION OF TYPE-SPECIFIC C ANTIGEN IN VIRUS-FREE HAMSTER TUMOR CELLS INDUCED BY ADENOVIRUS TYPE 12. Proc Natl Acad Sci U S A. 1964 Mar;51:432–439. doi: 10.1073/pnas.51.3.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. HUEBNER R. J., ROWE W. P., LANE W. T. Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2051–2058. doi: 10.1073/pnas.48.12.2051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. ITO Y. A tumor-producing factor extracted by phenol from papillomatous tissue (Shope) of cottontail rabbits. Virology. 1960 Dec;12:596–601. doi: 10.1016/0042-6822(60)90182-3. [DOI] [PubMed] [Google Scholar]
  23. MCALLISTER R. M., LANDING B. H., GOODHEART C. R. ISOLATION OF AGENOVIRUSES FROM NEOPLASTIC AND NON-NEOPLASTIC TISSUES OF CHILDREN. Lab Invest. 1964 Aug;13:894–901. [PubMed] [Google Scholar]
  24. MCBRIDE W. D., WIENER A. IN VITRO TRANSFORMATION OF HAMSTER KIDNEY CELLS BY HUMAN ADENOVIRUS TYPE 12. Proc Soc Exp Biol Med. 1964 Apr;115:870–874. doi: 10.3181/00379727-115-29060. [DOI] [PubMed] [Google Scholar]
  25. NEGRONI G. ISOLATION OF VIRUSES FROM LEUKAEMIC PATIENTS. Br Med J. 1964 Apr 11;1(5388):927–929. doi: 10.1136/bmj.1.5388.927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. RUBIN H. CARCINOGENIC INTERACTIONS BETWEEN VIRUS, CELL, AND ORGANISM. JAMA. 1964 Nov 23;190:727–731. doi: 10.1001/jama.1964.03070210033006. [DOI] [PubMed] [Google Scholar]
  27. Rubin H. A VIRUS IN CHICK EMBRYOS WHICH INDUCES RESISTANCE IN VITRO TO INFECTION WITH ROUS SARCOMA VIRUS. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1105–1119. doi: 10.1073/pnas.46.8.1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. SMITH K. O., BENYESH-MELNICK M., FERNBACH D. J. STUDIES ON HUMAN LEUKEMIA. II. STRUCTURE AND QUANTITATION OF MYXOVIRUS-LIKE PARTICLES ASSOCIATED WITH HUMAN LEUKEMIA. J Natl Cancer Inst. 1964 Sep;33:557–570. [PubMed] [Google Scholar]
  29. SOHIER R., CHARDONNET Y., PRUNIERAS M. ISOLEMENT D'UN AD'ENOVIRUS TYPE I 'A PARTIR D'UNE AD'ENOPATHIE CERVICALE MALIGNE. Presse Med. 1963 Aug 31;71:1733–1734. [PubMed] [Google Scholar]
  30. SOUTHAM C. M. The role of viruses in neoplasia, with emphasis on human leukemia. J Pediatr. 1963 Jul;63:138–157. doi: 10.1016/s0022-3476(63)80312-1. [DOI] [PubMed] [Google Scholar]
  31. STEWART S. E., EDDY B. E., GOCHENOUR A. M., BORGESE N. G., GRUBBS G. E. The induction of neoplasms with a substance released from mouse tumors by tissue culture. Virology. 1957 Apr;3(2):380–400. doi: 10.1016/0042-6822(57)90100-9. [DOI] [PubMed] [Google Scholar]
  32. STOKER M. CELL-VIRUS RELATIONSHIPS WITH TUMOUR VIRUSES. Br Med Bull. 1964 May;20:145–148. doi: 10.1093/oxfordjournals.bmb.a070308. [DOI] [PubMed] [Google Scholar]
  33. TRENTIN J. J., YABE Y., TAYLOR G. The quest for human cancer viruses. Science. 1962 Sep 14;137(3533):835–841. doi: 10.1126/science.137.3533.835. [DOI] [PubMed] [Google Scholar]
  34. VOGT P. K. THE CELL SURFACE IN TUMOR VIRUS INFECTION. Cancer Res. 1963 Oct;23:1519–1527. [PubMed] [Google Scholar]

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