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. 1995 Apr;103(4):338–345. doi: 10.1289/ehp.95103338

Signal transduction: evolution of an idea.

M Rodbell 1
PMCID: PMC1519115  PMID: 7607133

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berridge M. J., Irvine R. F. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature. 1984 Nov 22;312(5992):315–321. doi: 10.1038/312315a0. [DOI] [PubMed] [Google Scholar]
  2. Birnbaumer L., Pohl S. L., Rodbell M. Adenyl cyclase in fat cells. 1. Properties and the effects of adrenocorticotropin and fluoride. J Biol Chem. 1969 Jul 10;244(13):3468–3476. [PubMed] [Google Scholar]
  3. Birnbaumer L., Rodbell M. Adenyl cyclase in fat cells. II. Hormone receptors. J Biol Chem. 1969 Jul 10;244(13):3477–3482. [PubMed] [Google Scholar]
  4. Bitensky M. W., Wheeler G. L., Aloni B., Vetury S., Matuo Y. Light- and GTP-activated photoreceptor phosphodiesterase: regulation by a light-activated GTPase and identification of rhodopsin as the phosphodiesterase binding site. Adv Cyclic Nucleotide Res. 1978;9:553–572. [PubMed] [Google Scholar]
  5. Bourne H. R., Coffino P., Tomkins G. M. Selection of a variant lymphoma cell deficient in adenylate cyclase. Science. 1975 Feb 28;187(4178):750–752. doi: 10.1126/science.163487. [DOI] [PubMed] [Google Scholar]
  6. Bär H. P., Hechter O. Adenyl cyclase and hormone action. I. Effects of adrenocorticotropic hormone, glucagon, and epinephrine on the plasma membrane of rat fat cells. Proc Natl Acad Sci U S A. 1969 Jun;63(2):350–356. doi: 10.1073/pnas.63.2.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carlier M. F. Actin polymerization and ATP hydrolysis. Adv Biophys. 1990;26:51–73. doi: 10.1016/0065-227x(90)90007-g. [DOI] [PubMed] [Google Scholar]
  8. Cassel D., Levkovitz H., Selinger Z. The regulatory GTPase cycle of turkey erythrocyte adenylate cyclase. J Cyclic Nucleotide Res. 1977 Dec;3(6):393–406. [PubMed] [Google Scholar]
  9. Codina J., Hildebrandt J. D., Birnbaumer L., Sekura R. D. Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase. J Biol Chem. 1984 Sep 25;259(18):11408–11418. [PubMed] [Google Scholar]
  10. Cooper D. M., Schlegel W., Lin M. C., Rodbell M. The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP. J Biol Chem. 1979 Sep 25;254(18):8927–8931. [PubMed] [Google Scholar]
  11. Coulter S., Rodbell M. Heterotrimeric G proteins in synaptoneurosome membranes are crosslinked by p-phenylenedimaleimide, yielding structures comparable in size to crosslinked tubulin and F-actin. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5842–5846. doi: 10.1073/pnas.89.13.5842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Daniel V., Litwack G., Tomkins G. M. Induction of cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and the isolation of resistant variants. Proc Natl Acad Sci U S A. 1973 Jan;70(1):76–79. doi: 10.1073/pnas.70.1.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Fung B. K. Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits. J Biol Chem. 1983 Sep 10;258(17):10495–10502. [PubMed] [Google Scholar]
  14. Gill D. M. Mechanism of action of cholera toxin. Adv Cyclic Nucleotide Res. 1977;8:85–118. [PubMed] [Google Scholar]
  15. Gilman A. G. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615–649. doi: 10.1146/annurev.bi.56.070187.003151. [DOI] [PubMed] [Google Scholar]
  16. Harwood J. P., Löw H., Rodbell M. Stimulatory and inhibitory effects of guanyl nucleotides on fat cell adenylate cyclase. J Biol Chem. 1973 Sep 10;248(17):6239–6245. [PubMed] [Google Scholar]
  17. Harwood J. P., Rodbell M. Inhibition by fluoride ion of hormonal activation of fat cell adenylate cyclase. J Biol Chem. 1973 Jul 25;248(14):4901–4904. [PubMed] [Google Scholar]
  18. Houslay M. D., Ellory J. C., Smith G. A., Hesketh T. R., Stein J. M., Warren G. B., Metcalfe J. C. Exchange of partners in glucagon receptor-adenylate cyclase complexes. Physical evidence for the independent, mobile receptor model. Biochim Biophys Acta. 1977 Jun 2;467(2):208–219. doi: 10.1016/0005-2736(77)90197-3. [DOI] [PubMed] [Google Scholar]
  19. Jahangeer S., Rodbell M. The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8782–8786. doi: 10.1073/pnas.90.19.8782. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Katada T., Ui M. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci U S A. 1982 May;79(10):3129–3133. doi: 10.1073/pnas.79.10.3129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Kempner E. S. Novel predictions from radiation target analysis. Trends Biochem Sci. 1993 Jul;18(7):236–239. doi: 10.1016/0968-0004(93)90169-n. [DOI] [PubMed] [Google Scholar]
  22. Krishna G., Weiss B., Brodie B. B. A simple, sensitive method for the assay of adenyl cyclase. J Pharmacol Exp Ther. 1968 Oct;163(2):379–385. [PubMed] [Google Scholar]
  23. Lad P. M., Welton A. F., Rodbell M. Evidence for distinct guanine nucleotide sites in the regulation of the glucagon receptor and of adenylate cyclase activity. J Biol Chem. 1977 Sep 10;252(17):5942–5946. [PubMed] [Google Scholar]
  24. Londos C., Salomon Y., Lin M. C., Harwood J. P., Schramm M., Wolff J., Rodbell M. 5'-Guanylylimidodiphosphate, a potent activator of adenylate cyclase systems in eukaryotic cells. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3087–3090. doi: 10.1073/pnas.71.8.3087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Londos C., Wolff J. Two distinct adenosine-sensitive sites on adenylate cyclase. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5482–5486. doi: 10.1073/pnas.74.12.5482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. MONOD J., CHANGEUX J. P., JACOB F. Allosteric proteins and cellular control systems. J Mol Biol. 1963 Apr;6:306–329. doi: 10.1016/s0022-2836(63)80091-1. [DOI] [PubMed] [Google Scholar]
  27. Nakamura S., Rodbell M. Glucagon induces disaggregation of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranes. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7150–7154. doi: 10.1073/pnas.88.16.7150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Nakamura S., Rodbell M. Octyl glucoside extracts GTP-binding regulatory proteins from rat brain "synaptoneurosomes" as large, polydisperse structures devoid of beta gamma complexes and sensitive to disaggregation by guanine nucleotides. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6413–6417. doi: 10.1073/pnas.87.16.6413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Neubig R. R. Membrane organization in G-protein mechanisms. FASEB J. 1994 Sep;8(12):939–946. doi: 10.1096/fasebj.8.12.8088459. [DOI] [PubMed] [Google Scholar]
  30. Neville D. M., Jr Isolation of an organ specific protein antigen from cell-surface membrane of rat liver. Biochim Biophys Acta. 1968 Apr 9;154(3):540–552. doi: 10.1016/0005-2795(68)90014-7. [DOI] [PubMed] [Google Scholar]
  31. Northup J. K., Smigel M. D., Sternweis P. C., Gilman A. G. The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. J Biol Chem. 1983 Sep 25;258(18):11369–11376. [PubMed] [Google Scholar]
  32. Pfeuffer T. GTP-binding proteins in membranes and the control of adenylate cyclase activity. J Biol Chem. 1977 Oct 25;252(20):7224–7234. [PubMed] [Google Scholar]
  33. Pfeuffer T., Helmreich E. J. Activation of pigeon erythrocyte membrane adenylate cyclase by guanylnucleotide analogues and separation of a nucleotide binding protein. J Biol Chem. 1975 Feb 10;250(3):867–876. [PubMed] [Google Scholar]
  34. RODBELL M. METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem. 1964 Feb;239:375–380. [PubMed] [Google Scholar]
  35. Rendell M. S., Rodbell M., Berman M. Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an "excited" state of GTPase is a control component of the system. J Biol Chem. 1977 Nov 25;252(22):7909–7912. [PubMed] [Google Scholar]
  36. Rodbell M., Birnbaumer L., Pohl S. L., Krans H. M. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. J Biol Chem. 1971 Mar 25;246(6):1877–1882. [PubMed] [Google Scholar]
  37. Rodbell M., Jones A. B., Chiappe de Cingolani G. E., Birnbaumer L. The actions of insulin and catabolic hormones on the plasma membrane of the fat cells. Recent Prog Horm Res. 1968;24:215–254. doi: 10.1016/b978-1-4831-9827-9.50011-3. [DOI] [PubMed] [Google Scholar]
  38. Rodbell M., Jones A. B. Metabolism of isolated fat cells. 3. The similar inhibitory action of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on lipolysis stimulated by lipolytic hormones and theophylline. J Biol Chem. 1966 Jan 10;241(1):140–142. [PubMed] [Google Scholar]
  39. Rodbell M., Krans H. M., Pohl S. L., Birnbaumer L. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon. J Biol Chem. 1971 Mar 25;246(6):1872–1876. [PubMed] [Google Scholar]
  40. Rodbell M., Lin M. C., Salomon Y. Evidence for interdependent action of glucagon and nucleotides on the hepatic adenylate cyclase system. J Biol Chem. 1974 Jan 10;249(1):59–65. [PubMed] [Google Scholar]
  41. Rodbell M. Metabolism of isolated fat cells. II. The similar effects of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on glucose and amino acid metabolism. J Biol Chem. 1966 Jan 10;241(1):130–139. [PubMed] [Google Scholar]
  42. Rodbell M. Metabolism of isolated fat cells. VI. The effects of insulin, lipolytic hormones, and theophylline on glucose transport and metabolism in "ghosts". J Biol Chem. 1967 Dec 25;242(24):5751–5756. [PubMed] [Google Scholar]
  43. Rodbell M. The role of GTP-binding proteins in signal transduction: from the sublimely simple to the conceptually complex. Curr Top Cell Regul. 1992;32:1–47. doi: 10.1016/b978-0-12-152832-4.50003-3. [DOI] [PubMed] [Google Scholar]
  44. Rodbell M. The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature. 1980 Mar 6;284(5751):17–22. doi: 10.1038/284017a0. [DOI] [PubMed] [Google Scholar]
  45. Ross E. M., Gilman A. G. Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem. 1977 Oct 25;252(20):6966–6969. [PubMed] [Google Scholar]
  46. Ross E. M., Howlett A. C., Ferguson K. M., Gilman A. G. Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. J Biol Chem. 1978 Sep 25;253(18):6401–6412. [PubMed] [Google Scholar]
  47. SUTHERLAND E. W., RALL T. W., MENON T. Adenyl cylase. I. Distribution, preparation, and properties. J Biol Chem. 1962 Apr;237:1220–1227. [PubMed] [Google Scholar]
  48. Salomon Y., Londos C., Rodbell M. A highly sensitive adenylate cyclase assay. Anal Biochem. 1974 Apr;58(2):541–548. doi: 10.1016/0003-2697(74)90222-x. [DOI] [PubMed] [Google Scholar]
  49. Salomon Y., Rodbell M. Evidence for specific binding sites for guanine nucleotides in adipocyte and hepatocyte plasma membranes. A difference in fate of GTP and guanosine 5'-(beta, gamma-imino) triphosphate. J Biol Chem. 1975 Sep 25;250(18):7245–7250. [PubMed] [Google Scholar]
  50. Schlegel W., Cooper D. M., Rodbell M. Inhibition and activation of fat cell adenylate cyclase by GTP is mediated by structures of different size. Arch Biochem Biophys. 1980 May;201(2):678–682. doi: 10.1016/0003-9861(80)90559-7. [DOI] [PubMed] [Google Scholar]
  51. Schlegel W., Kempner E. S., Rodbell M. Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins. J Biol Chem. 1979 Jun 25;254(12):5168–5176. [PubMed] [Google Scholar]
  52. Schramm M., Rodbell M. A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes. J Biol Chem. 1975 Mar 25;250(6):2232–2237. [PubMed] [Google Scholar]
  53. Sternweis P. C., Northup J. K., Smigel M. D., Gilman A. G. The regulatory component of adenylate cyclase. Purification and properties. J Biol Chem. 1981 Nov 25;256(22):11517–11526. [PubMed] [Google Scholar]
  54. Sutherland E. W., Robison G. A. The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. Pharmacol Rev. 1966 Mar;18(1):145–161. [PubMed] [Google Scholar]
  55. Tang W. J., Gilman A. G. Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science. 1991 Dec 6;254(5037):1500–1503. doi: 10.1126/science.1962211. [DOI] [PubMed] [Google Scholar]
  56. Ting T. D., Ho Y. K. Molecular mechanism of GTP hydrolysis by bovine transducin: pre-steady-state kinetic analyses. Biochemistry. 1991 Sep 17;30(37):8996–9007. doi: 10.1021/bi00101a013. [DOI] [PubMed] [Google Scholar]
  57. Tolkovsky A. M., Levitzki A. Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochemistry. 1978 Sep 5;17(18):3795–3795. doi: 10.1021/bi00611a020. [DOI] [PubMed] [Google Scholar]
  58. Welton A. F., Lad P. M., Newby A. C., Yamamura H., Nicosia S., Rodbell M. Solubilization and separation of the glucagon receptor and adenylate cyclase in guanine nucleotide-sensitive states. J Biol Chem. 1977 Sep 10;252(17):5947–5950. [PubMed] [Google Scholar]
  59. Yamamura H., Lad P. M., Rodbell M. GTP stimulates and inhibits adenylate cyclase in fat cell membranes through distinct regulatory processes. J Biol Chem. 1977 Nov 25;252(22):7964–7966. [PubMed] [Google Scholar]

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